2000
DOI: 10.1063/1.1305814
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Compact fiber-optic fluorosensor using a continuous-wave violet diode laser and an integrated spectrometer

Abstract: A compact fluorosensor with a fiber-optic measurement probe was developed, employing a continuous-wave violet diode laser as an exciting source and an integrated digital spectrometer for the monitoring of fluorescence signatures. The system has the dimensions 22×13×8 cm3, and features 5 nm spectral resolution and an excellent detectivity. Results from measurements on vegetation and human premalignant skin lesions are reported, illustrating the potential of the instrument.

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Cited by 33 publications
(24 citation statements)
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“…17 In the previous system 14 it was possible to measure the therapeutic light flux in the lesion but the system construction did not allow the measurements of other parameters. The sensitizer fluorescence was in that case assessed by using a separate fluorosensor 18,19 with a separate measurement fiber. The novel approach 20 reported in the present paper enables us to perform light flux as well as sensitizer fluorescence and oxygenation monitoring through the same fibers that deliver the therapeutic light.…”
Section: Introductionmentioning
confidence: 99%
“…17 In the previous system 14 it was possible to measure the therapeutic light flux in the lesion but the system construction did not allow the measurements of other parameters. The sensitizer fluorescence was in that case assessed by using a separate fluorosensor 18,19 with a separate measurement fiber. The novel approach 20 reported in the present paper enables us to perform light flux as well as sensitizer fluorescence and oxygenation monitoring through the same fibers that deliver the therapeutic light.…”
Section: Introductionmentioning
confidence: 99%
“…A fluorosensor based on a 395 nm diode laser is described in Ref. [10]. With commercial diode lasers now available at as low wavelengths as 375 nm a fluorosensor with multiple-wavelength excitation could in principle be constructed.…”
Section: Introductionmentioning
confidence: 99%
“…The instrument used for point-monitoring fluorescence spectroscopy is similar to a system described in detail elsewhere 15 . Excitation light at 375 nm was delivered through a 400 µm quartz fiber with a clear cut distal end.…”
Section: Fluorescence Point-monitoring Setupmentioning
confidence: 99%