Experiments were conducted in order to investigate the influences of flow rate, applied voltage, and electric conductivity on droplet size and size distribution of water electrosprays in the simple-jet mode. The results show that the electric potential decreases significantly the relative standard deviation (RSD) of the spray size distribution, with the best result obtained for Weber number, We ¼ 3.3 (240 ml/h) when the RSD decreases from 0.50 at 0 kV to 0.18 at 5 kV. We conclude that simple-jet mode electrosprays are a good option for applications which require monodisperse micrometer droplets with high throughput. V C 2012 American Institute of Physics.[http://dx.doi.org/10.1063/1.4729021]The generation of monodisperse sprays is crucial for many industrial and medical applications. [1][2][3][4][5][6][7] Among others, such sprays can be used to control droplet deposition in inkjet printing, 8 to improve lung targeting in drug inhalation technology 9,10 and they are known to enhance the evaporation rate in combustion systems. 11 Commonly, the droplets generated in these processes are formed from the breakup of a liquid ligament. The process is named after the mechanism used to create the filament, e.g., pressure gradients (pressure atomizers), gas streams (air assisted atomizers), centrifugal forces (rotary atomizers), and electrostatic forces (electrohydrodynamic atomizers). 1,12,13 Empirical and theoretical investigations have been done to understand the mechanism responsible for the formation of such sprays. Among them, the most famous one is the study done by Rayleigh 14 who found that noncompressible inviscid liquid jets are unstable regarding axisymmetric disturbances of wave number (k) less than a certain cut-off wave number, i.e., the critical wave number (k c ) and calculated that the diameter of the formed droplet (d) is related to the jet diameter (D) as d % 1.89 Â D. From nonlinear theory, we know nowadays that for each disturbance forming a main droplet one or more usually smaller droplets (satellite or secondary droplets) can be formed. 1 However, it is possible to disturb the jet such that these satellite droplets are not formed, thereby generating a monodisperse spray. 1,15 From all the above mentioned atomization methods, electrohydrodynamic atomization (EHDA) is one of the few which is capable to generate monodisperse micrometer size droplets. Another unique feature of this method is the electric charge acquired by the droplets which provides self dispersion and prevents coalescence. 3,16 In view of these appealing characteristics, the production of monodisperse sprays using EHDA has attracted considerable attention in the literature. [2][3][4][5][6][7]10,12,17,18 Some examples are the works of Tang and Gomez (1994), who investigated monodisperse electrosprayed water droplets for targeted drug delivery 7 and monodisperse sprays of low conductivity liquids 3 as well as the works of Deng et al. (2009) and Arnanthigo et al. (2011) who have developed multiplex systems for the production of such spr...