A quartz enhanced photoacoustic spectroscopy (QEPAS) sensor system based on an elliptical laser beam for trace gas detection was demonstrated. A Powell lens was exploited to shape the circular laser beam into an elliptical laser beam for the full utilization of the quartz tuning fork (QTF) prong spacing. Based on the finite element modeling (FEM) simulation software COMSOL, the distribution of acoustic pressure on QTF prongs with different beam shapes was simulated theoretically. The experimental results showed that the QEPAS signal based on the elliptical laser beam had a 1.4-fold improvement compared with the circular laser beam, resulting in a minimum detection limit of 418.6 ppmv and the normalized noise equivalent absorption (NNEA) of 1.51 × 10 −6 cm −1 W/
√Hz at atmospheric pressure.