Comparaison de la nalbuphine et de la pentazocine dans le traitement de la douleur postopératoire par auto-administration

Pandele, G I; Nivoche, Y.; Marty, J.; Jm, Desmonts

doi:10.1016/s0750-7658(89)80157-1

Cited by 10 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pandèle et al . [ 16 ] also found significantly higher systolic blood pressure with pentazocine as compared to nalbuphine same as to our studies. On the other hand, Graham et al .…”

Section: Discussionsupporting

confidence: 91%

Comparative study of efficacy of preoperative nalbuphine hydrochloride and pentazocine lactate on hemodynamic response to tracheal intubation and postoperative analgesia

Sadafule¹,

Karhade²

2018

Anesth Essays Res

View full text Add to dashboard Cite

Background:For General anaesthesia perioperative administration of opioids are choice of drugs to attenuate intubation response and to provide good intraoperative and postoperative analgesia. Mixed agonist-antagonist opioids produces powerful analgesia without undesirable side effects.Aim:Aim of present study to compare efficacy of Nalbuphine and Pentazocine on hemodynamic response to tracheal intubation and postoperative analgesia.Settings:Present study carried out in operation theater.Design:This is prospective randomized double blind controlled trial.Material and Methods:Patients of ASA physical status I and II, age 20-60 years undergoing abdominal surgical procedure of 1-2 hour duration were randomly divided into two groups of 30 patients each (Group N) receiving nalbuphine 0.3 mg.kg-1 and (Group P) receiving pentazocine 0.6 mg.kg-1 intravenously before induction. Baseline vital parameters were noted and then noted till 15 minutes after intubation to see hemodynamic response. Time of rescue analgesia required was noted postoperatively.Stastical Analysis:Chi-square test, paired and unpaired t-test were used for statistical analysis.Results:There is rise in heart rate, blood pressure after intubation in both groups but rise was more with Pentazocine as compared to Nalbuphine (P < 0.05). Postoperatively within 30 minutes 60% of patient from Pentazocine group require rescue analgesia compare to only 16.60% of patient of Nalbuphine group (P = 0.05) which is highly significant.Conclusion:Nalbuphine is potent mixed opioid analgesic which can be used for attenuation of pressor response of tracheal intubation and for perioperative analgesia with minimal side effects.

show abstract

“…Pandèle et al . [ 16 ] also found significantly higher systolic blood pressure with pentazocine as compared to nalbuphine same as to our studies. On the other hand, Graham et al .…”

Section: Discussionsupporting

confidence: 91%

Comparative study of efficacy of preoperative nalbuphine hydrochloride and pentazocine lactate on hemodynamic response to tracheal intubation and postoperative analgesia

Sadafule¹,

Karhade²

2018

Anesth Essays Res

View full text Add to dashboard Cite

show abstract

“…Significant difference in the side effects was not noted. 13 In a double-blind comparison between nalbuphine and pentazocine in the control of postoperative pain after orthopedic surgery, 14 authors found that onset, duration, and quality of pain relief were significantly superior for nalbuphine, with 50% of the patients having no or only moderate pain at the end of the observation period. Cardiovascular and side effects were minor in both groups.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Analgesic Effects of Intravenous Nalbuphine and Pentazocine in Patients posted for Short-duration Surgeries: A Prospective Randomized Double-blinded Study

Apte¹,

Bhalerao²,

Lokapur³

et al. 2017

Journal on Recent Advances in Pain

View full text Add to dashboard Cite

Background and objectives: Postoperative pain influences the long-term outcome of the patient in a big way. We performed a randomized prospective double-blind study to evaluate the effects of intravenous (IV) nalbuphine and compared it with IV pentazocine. The primary objective was to compare the duration of analgesia of IV nalbuphine and IV pentazocine and the secondary objective was to study the side-effect profile.

show abstract

“…Pentazocine (PTZ) is widely used for pain control in Japan, acts on central μ-and κ-opioid receptors, 6,7) and produces analgesic effects by inhibiting the stimulus conduction system. 8,9) As a result, morphine-like side effects, such as nausea, dizziness, headache, insomnia, increased blood pressure, and decreased respiratory rate, [10][11][12] are observed. Moreover, fatal PTZ overdose and abuse have been reported, and some studies revealed that the entry point for people who fall into inappropriate self-injection is medical in origin.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic/Pharmacodynamic Modeling and Simulation of the Analgesic Effects of Pentazocine Using Perioperative Real-World Data

Omori

Aoyama

Miyamoto

et al. 2022

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Pentazocine (PTZ) is a widely used drug for postoperative pain. It should be administered at appropriate dosing intervals not only because of its morphine-like side effects but also because frequent inappropriate dosing can lead to dependence. Although perioperative patients reportedly have nonnegligible effects on placebo drugs and postoperative wound healing, no pharmacokinetic (PK)/pharmacodynamic (PD) model has been established and simulated using real-world data for the perioperative period. This study aimed to perform PTZ modeling and simulation and to establish an indicator of the timing of drug efficacy evaluation in clinical practice. Participants were in-hospital orthopedic surgery patients who received 15 mg of PTZ within 48 h postoperatively. Pain severity was assessed using the numerical rating scale (NRS). A two-compartment model was selected for the population PK model and an indirect response model for the PK/PD model. Using these models, a virtual population of 1000 patients with Pain base NRS of 5 and 6 and body weights of 40, 80, and 120 kg were treated with single and multiple PTZ administrations (4, 8, and 24 h apart) of 15 mg. Simulation results indicate that its analgesic efficacy should be evaluated within 1 h after administration of 15 mg of PTZ. Additional doses should be considered every 8-12 h in postoperative patients with Pain base NRS of 5 weighing 40-80 kg. Simulation using the PK/PD model developed in this study may provide useful information for determining the analgesic effects and timing of the dosing interval after PTZ administration in perioperative patients.

show abstract

Comparaison de la nalbuphine et de la pentazocine dans le traitement de la douleur postopératoire par auto-administration

Cited by 10 publications

References 3 publications

Comparative study of efficacy of preoperative nalbuphine hydrochloride and pentazocine lactate on hemodynamic response to tracheal intubation and postoperative analgesia

Comparative study of efficacy of preoperative nalbuphine hydrochloride and pentazocine lactate on hemodynamic response to tracheal intubation and postoperative analgesia

Comparison of Analgesic Effects of Intravenous Nalbuphine and Pentazocine in Patients posted for Short-duration Surgeries: A Prospective Randomized Double-blinded Study

Pharmacokinetic/Pharmacodynamic Modeling and Simulation of the Analgesic Effects of Pentazocine Using Perioperative Real-World Data

Contact Info

Product

Resources

About