1986
DOI: 10.1016/0742-8413(86)90110-6
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Comparative actions of quisqualate and N-methyl-d-aspartate, excitation amino acid agonists, on guinea-pig cochlear potentials

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Cited by 43 publications
(20 citation statements)
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“…It seems likely that amino acid transport in this medium would be very similar to that occurring naturally. A HEPES buffered artificial perilymph similar to that used in our studies (Barron et al, 1987) as well as a bicarbonate buffered artificial perilymph (Jenison et al, 1986) have been shown not to affect the cochlear potentials in the guinea pig (Littman et al, 1989). In our studies, the replacement of calcium chloride with choline chloride decreased the uptake of GLN, whereas an increase of potassium after uptake caused release of the accumulated label.…”
Section: Biochemical and Methodological Factorsmentioning
confidence: 72%
“…It seems likely that amino acid transport in this medium would be very similar to that occurring naturally. A HEPES buffered artificial perilymph similar to that used in our studies (Barron et al, 1987) as well as a bicarbonate buffered artificial perilymph (Jenison et al, 1986) have been shown not to affect the cochlear potentials in the guinea pig (Littman et al, 1989). In our studies, the replacement of calcium chloride with choline chloride decreased the uptake of GLN, whereas an increase of potassium after uptake caused release of the accumulated label.…”
Section: Biochemical and Methodological Factorsmentioning
confidence: 72%
“…Although EAAs act on various receptor subtypes in the cochlea, including the NMDA (Eybalin, 1993), the kainate (Bledsoe et al, 1981;Jenison et al, 1986), and the quisqualate/AMPA subtypes (Jenison et al, 1986), glutamate is considered the best candidate for mediating neurotransmission between cochlear inner hair cells and the afferent auditory nerve dendrites (Eybalin, 1993). L-glutamate activates all glutamate receptor subtypes; however, most of the neuronal cyclic guanosine monophosphate (cGMP) response to glutamate is initiated by Ca +2 flux through the NMDA receptor (Garthwaite, 1991).…”
Section: Discussionmentioning
confidence: 99%
“…In the cochlea, excessive glutamate and aspartate have been shown to cause ototoxicity, as demonstrated by elevated cochlear compound action potential (CAP) thresholds (Bobbin and Thompson, 1978). The EAAs in the cochlea function primarily via three types of glutamate receptors: (1) N-methyl-D-aspartate (NMDA) ( [Eybalin, 1993) which binds L-glutamate (2) kainate (Bledsoe et al, 1981;Jenison et al, 1986) (3) quisqualate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor subtypes (Jenison et al, 1986). Activation of NMDA and kainate receptors are most commonly associated with excitotoxicity (Lefebvre et al, 1991).…”
Section: Introductionmentioning
confidence: 99%
“…The studies on the receptors of the guinea pig cochlea showed that KA excited the primary afferent nerve fibers and that the effect was due to the influence on the postsynaptic receptors . Another agonist of excitatory amino acid receptors -Q -had fundamentally the same effect, while NMDA exerted no effect either on the AP or on the CM (Jenison and Bobbin 1983;Jenison et al 1986). From these experiments it follows that Q is about two orders of magnitude as effective as L-GLU and fourfold as effective as KA.…”
Section: Glutamate and Aspartatementioning
confidence: 89%