Comparative Analgesic and Anti-inflammatory Activities of Two Polyherbal Tablet Formulations (Aujaie and Surangeen) in Rats

Akhtar,; Malik, Abdul; Saleem,; Murtaza, Ghulam

doi:10.4314/tjpr.v12i4.24

Cited by 1 publication

(2 citation statements)

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“…Oral treatment with Qurs-Saffron or Quknar in albino mice showed significant inhibition of formalin-induced paw edema in animal models (Table 1). The current results showed the dose dependent augmentation in analgesic activity from both polyherbal formulations in animal models that were comparable with previously reported studies in context of other polyherbal tablets [7,8,26]. Moreover, Ibuprofen also showed significant analgesic activity in animal model.…”

Section: Discussionsupporting

confidence: 92%

“…So, the alternative sources including herbal formulations could be used for their anti-inflammatory, anti-oxidant and analgesic potentials with low cost and less adverse effects [5]. Moreover, polyherbal formulations such as peedantak, vati, aujaie and surangeen [6,7] have the advantage of multiple active ingredients with synergistic effects that might not be achieved with individual plants i.e. Moringa oleifera [8].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Anti-Inflammatory and Analgesic Activities of Qurs-Saffron and Quknar Polyherbal Tablets in Mouse Model

Akhtar¹,

Malik²,

Arshad³

et al. 2020

RADS J. Pharm. Pharm. Sci.

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Objective: We aimed to study the anti-inflammatory and analgesic effects for two polyherbal tablets in animal model. Methods: Suspensions of Qurs-Saffron and Quknar polyherbal formulations (p.o.) were evaluated for their anti-inflammatory (in carrageenan-induced paw edema) and analgesic activities (in formalin-induced paw licking test) in albino mice using Ibuprofen (50 mg/kg, orally) as standard drug. Acute toxicity testing of suspensions from Qurs-Saffron and Quknar tablets was also performed at doses 1, 2 and 3 gm/kg, orally. Parametric data were evaluated by one way ANOVA followed by Tukey’s test while graphics were made using GraphPad Prism. Results: Administration of Qurs-Saffron (1000, 1500, 2000 mg/kg) and Quknar (500, 750, 1000 mg/kg) suspensions showed significant (P < 0.05) inhibition of paw edema and at later time point (after 3 hours), both suspensions showed highly significant (P < 0.001) inhibition of paw edema. In another experiment (formalin-induced paw licking test), Qurs-Saffron (2000 mg/kg) and Quknar (1000 mg/kg) showed the highly significant (P < 0.001) analgesic activity. Conclusion: Qurs-Saffron and Quknar tablets possessed anti-inflammatory and analgesic effects that were most likely due to flavonoids and phenolic compounds with free radical scavenging properties which significantly reduced inflammation and pain in treated mice and were also found safe in toxicity testing.

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Section: Discussionsupporting

confidence: 92%