Comparative analysis between Liquid Based Cytology and Conventional Pap Smears at B P Koirala Memorial Cancer Hospital in Bharatpur, Chitwan, Nepal

Abstract

Background and Objective: Liquid based cytology was introduced at B P Koirala Memorial Cancer Hospital in Bharatpur, Chitwan, Nepal, on 29th November 2017. The objective of this study was to compare the results of conventional pap smears over six (6) months periods from 29th May 2017 to 28th November 2017 with the results of liquid based cytology smears over six (6) months periods from 29th November 2017 to 28th May 2018.
 Methods: This is retrospective study. The results of conventional pap smears over 6 months and the results of liquid based cytology smears over 6 months periods were retrieved and analysed to give overall reporting profiles and compared between the two methods.
 Results: The percentage of unsatisfactory smears fell 3.9% by conventional pap smears methods where as the percentage of unsatisfactory smears fell 1.2% by liquid based cytology smears. There was an increase in the number of smears reported as dyskaryosis of any grade by liquid based cytology methods.
 Conclusion: The introduction of liquid based cytology led to improvements in unsatisfactory smear rates and also with significant pick up rates of dyskaryosis were maintained and improved.

Comparison between Conventional Cytology and Liquid-Based Cytology in the Tertiary Brazilian Navy Hospital in Rio de Janeiro

“…In our daily routine, we observed that the main causes of unsatisfactory samples for conventional cytology are obscuring blood/white blood cells, interfering substances, and cellularity excess. The percentage of unsatisfactory samples we observed for LBC is comparable to the literature [6, 13, 14]. They were higher when comparing to LBC, possibly to the adaptation of the gynecology staff to the new technique when it was implemented.…”

“…Pun et al [14] conducted a comparative study between conventional cytology (1,180 samples) and LBC (1,160 samples). The percentage of unsatisfactory samples was lower in the LBC group (1.2 vs. 3.9%), and there was an increase in the detection of epithelial atypia (ASC-US+) when LBC was implemented (3.77 vs. 2.71%).…”

Does Liquid-Based Technology Improve Detection of Cervical Epithelial Abnormalities and Worth in Low Resource Setting?

“…Several studies reported that LBC had more satisfactory smears when compared to CPS [9,[11][12][13][14][15]. The statistically significant difference between rates of adequacy between two methods was observed elsewhere [8,14,16].…”