Comparative Analysis of Apoptosis-inducing Activity of Codeine and Codeinone

Hitosugi, Naoko; Hatsukari, Ikusuke; Ohno, Rena; Hashimoto, Ken; Mihara, Saori; Mizukami, Satoshi; Nakamura, Shinichi; Sakagami, Hiroshi; Nagasaka, Hiroshi; Matsumoto, Isao; Kawase, Masami

doi:10.1097/00000542-200303000-00012

Cited by 16 publications

(8 citation statements)

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“…Regarding the life threatening effects of morphine, they are generally expected to happen at high doses; in the present study we applied the maximum tolerance dose of opium (150 mg/kg). Although there are a large number of reports regarding the effects of opiate derivatives on cells apoptosis in the literature (7-9, 14, 19, 23), to our knowledge, this is the first study on the effects of opium on ovary cell apoptosis. In a previous study, we demonstrated that opium treatment can differentially induce brain and liver cell apoptosis in diabetic and non-diabetic male and female rats (6).…”

Section: Discussionmentioning

confidence: 96%

“…Consumption of opium can effect some biochemical factors (3, 4), transforming growth factor β (TGF-β) (5), and causes brain and liver cells’ apoptosis (6). Considerable evidence is available suggesting that morphine (7-9), noscapine (10-13), codeine (14) and papaverine (15) have apoptotic activity in vitro and in vivo . Thus, the effect of opium on apoptosis and cell function could be different from pure drugs such as morphine, noscapine, codeine and papaverine because more than 20 alkaloids (16) and more than 70 constituents (17), have been detected in opium.…”

Section: Introductionmentioning

confidence: 99%

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Ovary Cells Apoptosis in Opium-Addicted Diabetic and Non-Diabetic Rats

Asadikaram

Asiabanha

Sabet

2013

Int J High Risk Behav Addict

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BackgroundApoptosis is a physiological mechanism of cell death and it can be triggered by a variety of internal and external stimuli. It has been indicated that some opium derivatives develop cell apoptosis.ObjectivesThe aim of this investigation was to evaluate the effect of opium addiction on ovary cell apoptosis in diabetic and non-diabetic Wistar rats.Materials and MethodsThis experimental study was done on control, control-addicted, diabetic and diabetic-addicted rats. DNA fragmentation as a biomarker of apoptosis was determined by the TUNEL assay.ResultsThe blood glucose concentration in diabetic-addicted and diabetic rats was increased when compared to control (P < 0.001). There was no significant difference between weights of control, control-addicted (non-diabetic) and diabetic-addicted groups during this study. The results of this study indicated that apoptosis in addicted and diabetic-addicted ovary cells was significantly higher than in diabetic group, and also apoptosis in addicted group was significantly more than the control rats. In addition, we found that ovary cells apoptosis of diabetic rats were significantly less than in control group.ConclusionsOverall, these findings suggest that opium-addiction could play an important role in ovary cell apoptosis and could be very harmful for the reproductive system. Also, ovary cells of non-diabetic rats are more susceptible to opium-induced apoptosis than those of diabetic.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Ovary Cells Apoptosis in Opium-Addicted Diabetic and Non-Diabetic Rats

Asadikaram

Asiabanha

Sabet

2013

Int J High Risk Behav Addict

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“…In the present study, the growth inhibitory effects of codeine were increased by Fe(III), suggesting that the combination of morphine and Nx might be useful to supplement cancer therapy. We have recently found that codeinone had high cytotoxic activity against various cancer cell lines [28,29], as compared with codeine, suggesting its applicability for the treatment of cancer.…”

Section: Anticancer Activitymentioning

confidence: 99%

Synthesis, Characterization and Biological Properties of New Codeine Fe(iii) Complex

Ghamami

Golzani

Lashgari

2016

J. Chil. Chem. Soc.

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The reaction of FeCl 3 hexahydrate with C 18 H 20 NO 3 .PO 4 in acetonitrile produced new complex with general formula [Fe(L)]Cl 2 , (L= codeine). Characterization of the ligand and its complex were made by elemental analysis, FT-IR, 1 H-NMR, Raman and UV-visible spectroscopy. This new complex showed antitumor activity against two kinds of cancer cell lines: AGS (Stomach) and MCF-7 (Breast). Cell cytotoxic effects of the ligand and its complex were assayed by MTT and Natural-red tests. The antibacterial activity of ligand and complex against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes and Escherichia coli were also examined.

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“…Apoptosis is also a pathologic feature of the brain injury, certain inflammatory diseases of the brain and central nervous system infection, such as human immunodeficiency virus (HIV)-associated dementia [2]. Apoptotic effects of opioids such as morphine [3-7], heroines [8], codeine [9], in neurons has been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the lack of literature on the effects of opium we aimed this project to examine its effects on brain and liver cells apoptosis. Apoptotic activity of morphine [3-5] noscapine [14-17], codeine [9] and papaverine [18] has been shown in the in vitro and in vivo experimental systems. Morphine promotes Jurkat cells apoptosis [3] Morphine enhances the expression of both Fas and Fas ligand (FasL), and induces macrophage apoptosis [6].…”

Section: Introductionmentioning

confidence: 99%

Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats

Asiabanha

Asadikaram

Rahnema

et al. 2011

Korean J Physiol Pharmacol

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It has been shown that some opium derivatives promote cell death via apoptosis. This study was designed to examine the influence of opium addiction on brain and liver cells apoptosis in male and female diabetic and non-diabetic Wistar rats. This experimental study was performed on normal, opium-addicted, diabetic and diabetic opium-addicted male and female rats. Apoptosis was evaluated by TUNEL and DNA fragmentation assays. Results of this study showed that apoptosis in opium-addicted and diabetic opium-addicted brain and liver cells were significantly higher than the both normal and diabetic rats. In addition, we found that apoptosis in brain cells of opium-addicted and diabetic opium-addicted male rats were significantly higher than opium-addicted and diabetic opium-addicted female, whereas apoptosis in liver cells of opium-addicted and diabetic opium-addicted female rats were significantly higher than opium-addicted and diabetic opium-addicted male. Overall, these results indicate that opium probably plays an important role in brain and liver cells apoptosis, therefore, leading neurotoxicity and hepatotoxicity. These findings also in away possibly means that male brain cells are more susceptible than female and interestingly liver of females are more sensitive than males in induction of apoptosis by opium.

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Comparative Analysis of Apoptosis-inducing Activity of Codeine and Codeinone

Abstract: Codeinone was found to possess both apoptosis and necrosis-inducing activity, in addition to the reported antinociceptive activity, further substantiating its antitumor potential.

Cited by 16 publications

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Ovary Cells Apoptosis in Opium-Addicted Diabetic and Non-Diabetic Rats

Ovary Cells Apoptosis in Opium-Addicted Diabetic and Non-Diabetic Rats

Synthesis, Characterization and Biological Properties of New Codeine Fe(iii) Complex

Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats

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