Comparative Analysis of Blood Chemical Values in Primary Ketosis and Abomasal Displacement in Cows

Abstract

Blood chemical values, including ketone bodies, were measured in 25 cows with abomasal displacement (displacement group), 16 cows with primary ketosis (ketosis group), and nine normal controls to investigate the pathophysiology of abomasal displacement. Increases in aspartate aminotransferase, yglutamyl transpeptidase, non-esterified fatty acid (NEFA), and ketone bodies (3-hydroxybutyric acid and acetoacetic acid) were observed in the displacement and ketosis groups. Total cholesterol increased significantly in the ketosis group but decreased in the displacement group. Glucose was significantly low and reversely correlated to ketone bodies in the ketosis group but was not low and was not correlated with ketone bodies in the displacement group. While NEFA was correlated to ketone bodies in the ketosis group, it was not in the displacement group. A correlation between the values of acetoacetic acid and 3hydroxybutyric acid was seen in both the ketosis and displacement groups. The fact that blood chemical values in ketosis cows were clearly different from those in displacement cows suggests that the biochemical mechanism of ketogenesis is different between these two groups.

New Insights on Left Displaced Abomasum in Dairy Cows

“…Similar results were reported by Itoh et al (1998). The optimal BHBA concentration in dairy cows is below 1.0 mmol/L Whitaker et al (1983).…”

“…At the onset of lactation most dairy cows undergo negative energy balance due to increased nutrient demand than available feed intake Stengarde et al (2008). Stored body fat reserve will be mobilized to liver in attempt to meet energy demands which will lead to excessive fat accumulation in hepatic cells resulting in fatty liver and reduced lipoprotein synthesis Itoh et al (1998), LeBlanc et al (2005) and Mahmoud et al (2016).…”

Evaluation of oxidative stress, antioxidant status and lipid profile in cattle with displacement of the abomasum

“…The LDL, HDL and cholesterol changes are in agreement with other results of experiments carried out on high yielding cows with energy deficiency at postpartum (2,3,16,24). Lower LDL, HDL and cholesterol levels in the current study may be due to impairment of lipid metabolism.…”

Left displacement of the abomasum in dairy cattle: recent developments in epidemiological and etiological aspects

“…During the early lactation glucose and insulin blood levels decrease, whereas ketone bodies and non-esterified fatty acid level in the blood increase [25,58]. Patients with a displaced abomasum however, have often an elevated glucose and insulin level in the blood circulation [12,30,46]. Holtenius et al report decreased abomasal motility in cows with elevated insulin, glucose, and glucagon levels as well as in cows with high insulin combined with low glucose levels [27,28].…”