Comparative analysis of intronless genes in teleost fish genomes: Insights into their evolution and molecular function

Tine, Mbaye; Kuhl, Heiner; Beck, Alfred; Bargelloni, Luca; Reinhardt, Richard

doi:10.1016/j.margen.2011.03.004

Cited by 19 publications

(21 citation statements)

References 53 publications

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“…Many transcriptionally active intronless genes exist in teleost fish genomes. By comparative genomic analysis, it appears that loss of introns in teleost genes occurs by incremental steps, one or two introns at a time, through a process of homologous recombination between the cDNA and the genomic sequence encoding that cDNA [30,31]. In contrast, the intronless fabp11a gene most likely arose by illegitimate recombination [32] between the fabp11a cDNA and an unrelated region of the medaka genome.…”

Section: Resultsmentioning

confidence: 99%

The evolutionary relationship of the transcriptionally active fabp11a (intronless) and fabp11b genes of medaka with fabp11 genes of other teleost fishes

2012

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Here we describe the structure of the fatty acid-binding protein 11a and 11b genes (fabp11a and fabp11b) in medaka, and their evolutionary relationship to fabp11 genes from other teleost fishes. Initial studies indicated that the medaka fabp11a gene is intronless, but the fabp11b gene consists of four exons separated by three introns, a genomic organization that is characteristic of most members of the intracellular lipid-binding protein family. Based on genomic sequence, we conclude that the intronless fabp11a gene most likely arose as a result of reverse transcription of its mRNA transcript into cDNA followed by integration into chromosomal DNA. The ancestral intron-containing fabp11a gene was presumably lost from the medaka genome. The duplicated fabp11 genes extant in medaka encode polypeptides of 134 amino acids, which share highest sequence identity and similarity, and cluster in a distinct phylogenetic clade, with their orthologs in other teleost fishes. The fabp11a and fabp11b genes in medaka are therefore orthologs of the fabp11a and fabp11b genes, respectively, of other teleost fishes. No conserved gene synteny was found between medaka fabp11a and fabp11a genes from other teleost fishes, supporting our suggestion as to how this intronless gene arose. However, conserved gene synteny was evident between medaka fabp11b and fabp11b genes from other teleost fishes. The tissue-specific distribution of transcripts for medaka and zebrafish fabp11a and fabp11b genes revealed acquisition of a new function(s) in various tissues by the medaka fabp11b gene, which may explain the retention of sister duplicates of fabp11 in the medaka genome.

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Section: Resultsmentioning

confidence: 99%

The evolutionary relationship of the transcriptionally active fabp11a (intronless) and fabp11b genes of medaka with fabp11 genes of other teleost fishes

2012

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“…Even more surprisingly, comparative analyses among different species revealed only a small overlap among single exon genes to be evolutionarily conserved. Such differences instead point at the evolvement of single exon genes after the evolutionary divergence of species 23 . One likely explanation for the diversification of claudins among teleosts is the involvement of retrotransposition events followed by tandem duplications.…”

Section: Zebrafish Claudin Orthologs Of Mammalian Claudins Of the Bbbmentioning

confidence: 99%

“…Such differences instead point at the evolvement of single exon genes after the evolutionary divergence of species. 23 One likely explanation for the diversification of claudins among teleosts is the involvement of retrotransposition events followed by tandem duplications. Experimentally, subfunctionalizations of these genes have opened the possibility of addressing the role of particular claudins in a tissue-or temporal-specific manner in teleosts.…”

Section: Zebrafish Claudin Orthologs Of Mammalian Claudins Of the Bbbmentioning

confidence: 99%

Involvement of claudins in zebrafish brain ventricle morphogenesis

Zhang

Liss

Wolburg

et al. 2012

Annals of the New York Academy of Sciences

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Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow- and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelial-ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the blood-brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.

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“…Among the known teleost fish genomes, the Takifugu rubripes, Tetraodon nigroviridis, Oryzias latipes, Gasterosteus aculeatus and Danio rerio genomes contain 2.83%, 3.42%, 4.49%, 4.35% and 4.02% SEGs, respectively [22]. In many species, several chemokine receptors encoded by SEGs belong to the well-known G-protein-coupled receptor family, which includes odorant receptors, olfactory receptors, and metabotropic G-protein-coupled receptors (dopamine receptor) [22]. An analysis of CCR6 from other species (listed in Table 2) showed that all of them contain more than two exons, except some unknown sequences.…”

Section: Discussionmentioning

confidence: 99%

Molecular cloning, structure and expressional profiles of two novel single-exon genes (PoCCR6A and PoCCR6B) in the Japanese flounder (Paralichthys olivaceus)

Wang

Zhang

et al. 2016

Fish & Shellfish Immunology

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Comparative analysis of intronless genes in teleost fish genomes: Insights into their evolution and molecular function

Cited by 19 publications

References 53 publications

The evolutionary relationship of the transcriptionally active fabp11a (intronless) and fabp11b genes of medaka with fabp11 genes of other teleost fishes

The evolutionary relationship of the transcriptionally active fabp11a (intronless) and fabp11b genes of medaka with fabp11 genes of other teleost fishes

Involvement of claudins in zebrafish brain ventricle morphogenesis

Molecular cloning, structure and expressional profiles of two novel single-exon genes (PoCCR6A and PoCCR6B) in the Japanese flounder (Paralichthys olivaceus)

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