Comparative analysis of iron status and other hematological parameters in preeclampsia

Gutiérrez-Aguirre, César Homero; García-Lozano, José Alberto; Treviño-Montemayor, Oscar Rubén; Iglesias-Benavides, José Luis; Cantú-Rodrı́guez, Olga Graciela; González-Llano, Óscar; León, Andrés Gómez‐De; Salazar-Riojas, Rosario; Mancı́as-Guerra, Consuelo; Jaime‐Pérez, José Carlos; Guzmán-López, Abel; Gómez‐Almaguer, David

doi:10.1080/10245332.2016.1220120

Cited by 24 publications

(22 citation statements)

References 22 publications

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“…Our results that there is a hyperferritinaemia in PE are similar to other studies [23][24][25] . Raman et al 26 showed higher mean ferritin levels in pregnant women with pregnancy induced hypertension and PE, concluding that hyperferritinaemia may mask iron deficiency.…”

Section: Discussionsupporting

confidence: 93%

“…Iron overload has been associated with ferroptosis involving other organ systems 5 , notably those implicated in the pathophysiology of PE 25,[33][34][35] , as well as gestational diabetes (GDM), a condition also associated with adverse birth outcomes 29,[36][37][38] . While women who have anaemia should be treated, without understanding the cause of anaemia we risk subjecting women to iron overload.…”

Section: Discussionmentioning

confidence: 99%

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Querying the value of indiscriminate iron supplementation in pre-eclampsia: a cross-sectional study

Dorsamy

Bagwandeen

Moodley

2021

Preprint

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Objective To determine the prevalence and type of anaemia and its association with pre-eclampsia (PE) in pregnant South Africans of African ancestry. Design Cross-sectional study design Setting A regional hospital in KwaZulu-Natal, South Africa. Sample 671 women seeking antenatal care. Methods Participants had haemoglobin(Hb), anthropometric measurements, HIV status, blood pressure levels(BP) and proteinuria measured to determine PE. Iron studies and transferrin receptor levels were assessed in a subset and chi-square tests of association between normotensive and pre-eclampsia sub-groups and blood parameters were conducted. Results No difference in Hb concentration amongst the 4 groups (F (3,621)=0.981, p< .001, η2=.014) was observed. A chi-square test of association (χ2(3)=6.674, p=.083) showed no associations between study groups and having anaemia. The severity of anaemia did not vary amongst study groups (χ2(12) =10.756, p=.550). Using ferritin, there was an association between the study groups having an iron deficiency, anaemia, both or neither (χ2(3)=12.559, p=.045) with a positive association between normotensive term and iron deficiency (adjusted residual(AR) 2.2) and positive association between early-onset PE(AR 2.4). Similar trends were found for transferrin and soluble transferrin receptor ferritin index. Twenty-two percent of the participants were not iron deficient. Conclusion Early-onset PE is associated with high iron status and not anaemia. Normotensive term pregnancies were associated with iron deficiency anaemia. Broad iron supplementation without adequate determination of iron deficiency in pregnant women needs to be revisited. Funding National Research Foundation (TTK170508230162), University of KwaZulu-Natal UCPD and Medical Research Council of South Africa(SIR Grant UNS14197). Keywords Anaemia, iron deficiency, pre-eclampsia

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Querying the value of indiscriminate iron supplementation in pre-eclampsia: a cross-sectional study

Dorsamy

Bagwandeen

Moodley

2021

Preprint

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“…There is substantial, albeit indirect, evidence to support this hypothesis, summarized below:Numerous studies investigating the association between iron status and hypertensive disorders of pregnancy have noted that levels of circulating iron and ferritin, as well as the level of Tf saturation, are significantly higher in PE patients as compared to normotensive controls [135,136,137]. Whether or not the increased serum iron in PE is due to low circulating hepcidin levels is unclear.…”

Section: Molecular Basis For Dysregulated Iron Homeostasis In Preementioning

confidence: 99%

The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

Norwitz

2019

IJMS

110

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Iron is an essential element for the survival of most organisms, including humans. Demand for iron increases significantly during pregnancy to support growth and development of the fetus. Paradoxically, epidemiologic studies have shown that excessive iron intake and/or high iron status can be detrimental to pregnancy and is associated with reproductive disorders ranging from endometriosis to preeclampsia. Reproductive complications resulting from iron deficiency have been reviewed elsewhere. Here, we focus on reproductive disorders associated with iron overload and the contribution of ferroptosis—programmed cell death mediated by iron-dependent lipid peroxidation within cell membranes—using preeclampsia as a model system. We propose that the clinical expressions of many reproductive disorders and pregnancy complications may be due to an underlying ferroptopathy (elemental iron-associated disease), characterized by a dysregulation in iron homeostasis leading to excessive ferroptosis.

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“…pregnant with preeclampsia compared with the control group. 37 In the study of Laila et al (2014) regarding the relationship between serum ferritin and iron parameters with preeclampsia also have the same findings as the Gutierrez-Aguirre study. 38 The mechanism of increasing ferritin levels in some of the studies above can be explained by the theory of oxidative stress.…”

Section: Discussionmentioning

confidence: 65%

“…When the tissue becomes ischemic, reactive oxygen species such as superoxide and hydrogen peroxide are produced. 34,37,38 The presentation of the placenta in preeclamptic patients shows a histologic appearance with severe vascular damage in the area of attachment of decidua cells in the infarct area, this corresponds to cell damage and detachment. Fe.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Ferritine and Brain Derived Neurotrophic Factor (BDNF) Levels in Preeclampsia

Putri

Ariadi

Yusrawati

2021

AOJ

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Iron deficiency anemia that followed by low serum ferritin levels in early pregnancy has an indirect impact on decreasing the expression of Brain Derived Neurotrophic Factor (BDNF) in the maternal hippocampus. BDNF together with its receptor tyrosine kinase B (TrkB) induced the expression of metalloproteinase-9 (MMP-9) which plays an important role in blastocyst implantation, trophoblast invasion and placental development. Decreasing BDNF levels can interfere with those process which caused imbalance of pro-angiogenic and anti-angiogenic factors such as VEGF, PIGF, sFlt1 and sEng that leads to preeclampsia. This study aims to determine the correlation between ferritin and BDNF serum levels in preeclampsia.Keywords: Preeclampsia, ferritin, iron deficiency anemia, Brain Derived Neurotrophic Factor

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Comparative analysis of iron status and other hematological parameters in preeclampsia

Abstract: Higher SF levels, despite being within normal range, were associated with PE. The incidence of thrombocytopenia was higher in preeclamptic women, however, the remaining hematological parameters were similar in both groups.

Cited by 24 publications

References 22 publications

Querying the value of indiscriminate iron supplementation in pre-eclampsia: a cross-sectional study

Querying the value of indiscriminate iron supplementation in pre-eclampsia: a cross-sectional study

The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

Correlation of Ferritine and Brain Derived Neurotrophic Factor (BDNF) Levels in Preeclampsia

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