Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Cartilage, and Adipose Tissue

Peng, Linyi; Jia, Zhonghua; Yin, Xinhua; Zhang, Xin; Liu, Yinan; Chen, Ping; Ma, Kangtao; Zhou, Chunyan

doi:10.1089/scd.2007.0217

Cited by 324 publications

(266 citation statements)

References 27 publications

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“…5 Further, MSCs derived from adipose tissue possess the highest proliferation and differentiation potential, followed by MSCs derived from bone marrow and cartilage. 6 Differentiation into other phenotypes has also been reported. For example, Xu et al demonstrated the differentiation of ASCs into Schwann celllike cells.…”

Section: Introductionmentioning

confidence: 90%

Adipogenesis of Human Adipose-Derived Stem Cells Within Three-Dimensional Hollow Fiber-Based Bioreactors

Gerlach

Lin²,

Brayfield³

et al. 2012

Tissue Engineering Part C: Methods

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Section: Introductionmentioning

confidence: 90%

Adipogenesis of Human Adipose-Derived Stem Cells Within Three-Dimensional Hollow Fiber-Based Bioreactors

Gerlach

Lin²,

Brayfield³

et al. 2012

Tissue Engineering Part C: Methods

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“…5,11,12 In adults, mesenchymal cells derive from stem cells residing in the bone marrow and mesenchymal tissues. 13,14 These stem cells retain the ability to differentiate into cells of connective tissue lineages, including adipocytes, osteoblasts, chondrocytes, smooth and skeletal muscle, endothelial cells of blood vessels and fibroblasts (reviewed in Barry and Murphy 14 ). Differentiation of mesenchymal cells into specific cell types requires induction of a range of transcription factors 14 and may also involve interaction with cells of monocyte origin.…”

Section: Introductionmentioning

confidence: 99%

Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome

et al. 2010

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Mutations in the human FBN1 gene cause Marfan syndrome, a complex disease affecting connective tissues but with a highly variable phenotype. To identify genes that might participate in epistatic interactions with FBN1, and could therefore explain the observed phenotypic variability, we have looked for genes that are co-expressed with Fbn1 in the mouse. Microarray expression data derived from a range of primary mouse cells and cell lines were analysed using the network analysis tool BioLayout Express 3D . A cluster of 205 genes, including Fbn1, were selectively expressed by mouse cell lines of different mesenchymal lineages and by mouse primary mesenchymal cells (preadipocytes, myoblasts, fibroblasts, osteoblasts). Promoter analysis of this gene set identified several candidate transcriptional regulators. Genes within this co-expressed cluster are candidate genetic modifiers for Marfan syndrome and for other connective tissue diseases.

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“…This seems to be true since Ping et al [50] reported that mesenchymal stem cells possess antioxidant ROS-scavenging capacity and are resistant to hydrogen peroxide-induced apoptosis or ionizing radiation. This resistance to ROS were attributed to factors secreted by the mesenchymal stem cells as IGF, PDGF, SOD, IL-6, G-CSF, GM-CSF, IL-12 cytosolic superoxide dismutase, mitochondrial superoxide dismutase, catalase and glutathione peroxidase1 enzymes and also depends on the high level of intracellular total glutathione [51,52].…”

Section: Effect Of Stem Cell Therapy On % Of Fragmented Dna In Testicmentioning

confidence: 96%

Effect of Stem Cell Therapy on Gentamicin Induced Testicular Dysfunction in Rats

Sm¹,

Nm²,

Sf³

et al. 2017

J Health Med Inform

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Infertility is a worldwide problem affecting couples that have unprotected intercourse, so the current study investigated the possible ameliorative effect of intra testicular stem cell injection in rats subjected to gentamicin induced testicular degeneration. For this study 100 male rats were randomly allocated into 4 groups, namely, the control group (group I), gentamicin group (group II), stem cell group (group III) and gentamicin and stem cell group (group IV). Gentamicin was administered daily for 2 weeks (80 mg/kg) to groups (II and IV). Stem cells were injected intra testicular into rete testis once by the end of gentamicin administration in group (IV) or after I/P injection of saline in group III. Blood and testicular samples were collected by the end of weeks 2, 6 and 10 from group (I) and (II), and by the end of weeks 6 and 10 from group (III and IV). The obtained results showed a significant decreases in serum testosterone, testicular testosterone and estradiol, sperm counts, sperm viability and an increase in % of fragmented DNA (indicating degenerative and necrotic changes) in testicular tissue of group (II) compared to group I , III and IV. Mesenchymal stem cells administration significantly improved all altered testicular parameters, where values of group IV (except testicular estradiol) were not significantly different from those of control group (I). Conclusively, mesenchymal stem cells proved to be beneficial in rats subjected to gentamicin induced testicular dysfunctions.

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Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Cartilage, and Adipose Tissue

Cited by 324 publications

References 27 publications

Adipogenesis of Human Adipose-Derived Stem Cells Within Three-Dimensional Hollow Fiber-Based Bioreactors

Adipogenesis of Human Adipose-Derived Stem Cells Within Three-Dimensional Hollow Fiber-Based Bioreactors

Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome

Effect of Stem Cell Therapy on Gentamicin Induced Testicular Dysfunction in Rats

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