Comparative Analysis of Plasma Leptin Levels in Both Genders of Patients with Essential Hypertension and Healthy Subjects

Canatan, Halit; Bakan, İbrahim; Akbulut, Mehmet; Baydaş, Gıyasettin; Halifeoğlu, İhsan; Gürsu, Ferit

doi:10.1081/erc-120029889

Cited by 18 publications

(11 citation statements)

References 35 publications

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“…In the current study significantly ( P < 0.05) higher mean serum leptin levels were observed in women than men, 24 ng/ml and 10.6 ng/ml, respectively ( Table 1 ), with a P -value < 0.001. This is in agreement with previously published studies [ 23 51 52 53 ]. This gender variation is possibly due to testosterone effect in men to suppress leptin production in adipocytes [ 22 52 53 ].…”

Section: Discussionsupporting

confidence: 94%

Leptin and uric acid as predictors of metabolic syndrome in jordanian adults

et al. 2016

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BACKGROUND/OBJECTIVESMetabolic syndrome (MetS) is a set of interrelated metabolic risk factors that increase the risk of cardiovascular morbidity and mortality. Studies regarding the specificity and sensitivity of serum levels of leptin and uric acid as predictors of MetS are limited. The aim of this study was to evaluate the serum levels of leptin and uric acid in terms of their specificity and sensitivity as predictors of MetS in the studied Jordanian group.SUBJECTS/METHODSIn this cross sectional study, 630 adult subjects (308 men and 322 women) were recruited from the King Hussein Medical Center (Amman, Jordan). The diagnosis of MetS was made according to the 2005 International Diabetes Federation criteria. Receiver operating characteristic curves were used to determine the efficacy of serum levels of leptin and uric acid as predictors of MetS in the studied Jordanian group.RESULTSStudy results showed that for identification of subjects with MetS risk, area under the curve (AUC) for leptin was 0.721 and 0.683 in men and women, respectively. Serum uric acid levels in men showed no significant association with any MetS risk factors and no significant AUC, while uric acid AUC was 0.706 in women.CONCLUSIONSerum leptin levels can be useful biomarkers for evaluation of the risk of MetS independent of baseline obesity in both men and women. On the other hand, serum uric acid levels predicted the risk of MetS only in women.

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Section: Discussionsupporting

confidence: 94%

Leptin and uric acid as predictors of metabolic syndrome in jordanian adults

et al. 2016

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“…So, it is possible that a blunted effect of leptin may predispose to hypertension in humans (25,26). Scientists have observed the relationship between serum leptin and heart beat in hypertensive subjects (27,28). Role of leptin in causing cardiovascular diseases and hypertension has also been reported by the previous studies (29)(30)(31).…”

Section: Discussionmentioning

confidence: 80%

Correlation between leptin level and hypertension in normal and obese pre- and postmenopausal women

Khokhar

Sidhu²,

Kaur³

2010

European Journal of Endocrinology

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Objective: The present study was aimed at evaluating the correlation between leptin and hypertension in normal and obese hypertensive pre-(Pre-M) and postmenopausal (Post-M) women of Jalandhar city (Punjab, India). Design: For the present study, 78 Pre-M and Post-M women were recruited in four categories as follows: i) normal normotensive, ii) obese normotensive, iii) normal hypertensive, and iv) obese hypertensive. Body mass index was considered as the index of obesity. Guidelines given by JNC-VII were followed for the assessment of hypertension. Leptin was assayed by sandwich ELISA, and estradiol (E 2 ) was assayed by competitive ELISA. Results: Leptin level was found to be significantly higher in normal Pre-M women (P!0.02) than that of normal Post-M women. Obese subjects had significantly higher leptin level (P!0.001) than the normal women. In the case of hypertensive subjects, leptin level was significantly higher than that of normotensive counterparts. E 2 level was found significantly lower in Post-M women (P!0.001) than that of Pre-M women as well as in hypertensive women than that of normotensive subjects. A positive correlation was observed between blood pressure (BP) and leptin, but significant association was observed in hypertensive normal and obese Pre-M and Post-M women only. Conclusion: It is concluded from the present findings that leptin contributes to the regulation of BP in hypertensive normal as well as in the obese Pre-M and Post-M women. So, leptin may be a regulator of BP in hypertensive women independent of the degree of obesity and the menopausal status.

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“…Franks et al, 28 in a longitudinal study of adipocytokines with the development of the metabolic syndrome in women, also showed significant longitudinal associations between leptin levels and subsequent changes in metabolic parameters and the development of the metabolic syndrome. These longitudinal data are important additions to the literature, since cross-sectional studies are conflicting about leptin and blood pressure and lipid levels; some studies report that higher leptin levels are associated with adverse blood pressure and lipid profiles, [28][29][30][31] while some studies report null associations. [32][33][34] Adiponectin's association with metabolic parameters has been more consistently reported.…”

Section: Discussionmentioning

confidence: 99%

Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife: longitudinal associations

et al. 2008

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Background: There are limited data concerning the relationships between changes in adipocytokines and cardiovascular disease (CVD) risk factors. Objective: To examine the longitudinal associations between leptin, adiponectin, resistin and ghrelin levels and CVD risk factor levels in women at midlife. Design: Prospective, observational study. Subjects and measurements: Leptin, adiponectin, resistin, ghrelin levels and CVD risk factors were measured in specimens collected from 40 women at 3 points in time corresponding to the pre-, peri-and postmenopause stages of their natural menopause transition. Results: In longitudinal analyses adjusted for CVD risk factors and leptin at the previous menopausal stage, aging, education, smoking and physical activity, greater increases in leptin over the menopause transition were associated with greater decreases in high-density lipoprotein cholesterol (HDL-c) and greater increases in diastolic blood pressure, glucose, insulin and insulin resistance (all Po0.05). Larger decreases in adiponectin over the menopause transition were associated with greater increases in systolic blood pressure, insulin and insulin resistance and with greater decreases in HDL-c. Greater increases in ghrelin levels over the menopausal transition were associated with greater low-density lipoprotein cholesterol increases (P ¼ 0.014). Resistin was not associated with CVD risk factor changes. Conclusion: There were significant adverse associations of adipocytokines and ghrelin with multiple CVD risk factor changes in women across midlife. Given that this time period is dynamic for CVD risk, these data underscore the need for additional prospective studies.

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Comparative Analysis of Plasma Leptin Levels in Both Genders of Patients with Essential Hypertension and Healthy Subjects

Cited by 18 publications

References 35 publications

Leptin and uric acid as predictors of metabolic syndrome in jordanian adults

Leptin and uric acid as predictors of metabolic syndrome in jordanian adults

Correlation between leptin level and hypertension in normal and obese pre- and postmenopausal women

Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife: longitudinal associations

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