Leptin and uric acid as predictors of metabolic syndrome in jordanian adults

Abstract

BACKGROUND/OBJECTIVESMetabolic syndrome (MetS) is a set of interrelated metabolic risk factors that increase the risk of cardiovascular morbidity and mortality. Studies regarding the specificity and sensitivity of serum levels of leptin and uric acid as predictors of MetS are limited. The aim of this study was to evaluate the serum levels of leptin and uric acid in terms of their specificity and sensitivity as predictors of MetS in the studied Jordanian group.SUBJECTS/METHODSIn this cross sectional study, 630 adult subjects (308 men and 322 women) were recruited from the King Hussein Medical Center (Amman, Jordan). The diagnosis of MetS was made according to the 2005 International Diabetes Federation criteria. Receiver operating characteristic curves were used to determine the efficacy of serum levels of leptin and uric acid as predictors of MetS in the studied Jordanian group.RESULTSStudy results showed that for identification of subjects with MetS risk, area under the curve (AUC) for leptin was 0.721 and 0.683 in men and women, respectively. Serum uric acid levels in men showed no significant association with any MetS risk factors and no significant AUC, while uric acid AUC was 0.706 in women.CONCLUSIONSerum leptin levels can be useful biomarkers for evaluation of the risk of MetS independent of baseline obesity in both men and women. On the other hand, serum uric acid levels predicted the risk of MetS only in women.

Sex-specific association of serum uric acid dynamics with the incidence of metabolic syndrome in a health check-up Chinese population: a prospective cohort study

“…In short, our findings by a novel powerful method, JMLS, based on a follow-up study, indicated that the longitudinal increment in SUA could predict the risk of MetS only in females. Our findings are consistent with some previous studies, for instance, by Yang et al 16 and by Obeidat et al 19 A Open access possible mechanism of sex differences in the relationship between SUA level and MetS is possibly due to its effects on the kidneys, and the interaction between oestrogen and other hormones has been suggested as a possible cause for sex differences. 31 To date, there is no consensus on whether there is a sex difference in the association between SUA and MetS or its components.…”

“…31 To date, there is no consensus on whether there is a sex difference in the association between SUA and MetS or its components. [15][16][17][18][19][20] The diverse results may be ascribed to different ethnicities, sample sizes, covariates included, research designs and statistical models in the studies. Nonetheless, our findings are more realistic because they came from a joint model for longitudinal measurements of SUA and survival time to MetS, which is more advanced than traditional prediction models such as the Cox model.…”

“…[15][16][17][18] Some studies found that SUA level could predict the risk of MetS only in women. 19 However, some studies found that there was no sex difference in the risk of MetS caused by high SUA level. 20 These inconsistent results may be due to study populations of different ages and races.…”

<p>Obesity Indices for Identifying Metabolic Syndrome Among Type Two Diabetes Patients Attending Their Follow-Up in Dessie Referral Hospital, North east Ethiopia</p>

“…Similarly, a study done among Jordanian adults showed that WC for males, and WHtR for females were the best predictor for MetS. 26 It was also in line with a study done in Haryana, India which stated that WHtR was the best predictor of MetS irrespective of their sex, whereas WC was the best predictor for males and females. 24 However, studies done in Japan, Xinjiang (China) and Nigeria stated that WHtR was the best predictor for males and females.…”

Gambaran Kadar Asam Urat Serum pada Mahasiswa dengan Indeks Massa Tubuh ≥23 kg/m2 di Fakultas Kedokteran Universitas Sam Ratulangi

“…Perannya belum dapat dijelaskan secara pasti namun mekanisme yang dapat menjelaskan yaitu peningkatan produksi leptin pada orang yang obes diatur oleh gen obese (ob gene) yang dapat mengakibatkan hiperinsulinemia dan resistensi insulin yang kemudian menurunkan ekskresi asam urat. [11][12][13] Pada penelitian ini juga ditemukan empat responden memiliki kadar asam urat rendah (hipourisemia) yang terdiri dari satu respoden laki-laki dan tiga responden perempuan. Hipourisemia terjadi karena meningkatnya pembersihan asam urat lewat ginjal atau penurunan produksi asam urat baik dari sumber endogen maupun eksogen.…”