Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus

Lazarov, Nikolai

doi:10.1016/s0301-0082(01)00021-1

Cited by 253 publications

(234 citation statements)

References 446 publications

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“…Guilbaud et al (1993) clearly showed that myelinated fibers are the most vulnerable to CCI. In additional support of this interpretation, ATF3, which is considered as a marker of neuronal response to injury (Hai and Hartman, 2001) and is essentially expressed by medium to large neurons (Obata et al, 2003;Tsuzuki et al, 2003) from which originate myelinated fibers (Lazarov, 2002), was also found to exhibit a more robust and faster upregulation after IoN-CCI compared with SN-CCI. Interestingly, IL-6 mRNA increase in TG of IoN-CCI rats was detected as soon as 1.5 h after surgery with mRNA levels (ϫ33.85 Ϯ 7.75) even higher than at later postoperative times (Fig.…”

Section: Cytokines Neuronal and Glial Markers In Sensory Gangliamentioning

confidence: 79%

Differential Implication of Proinflammatory Cytokine Interleukin-6 in the Development of Cephalic versus Extracephalic Neuropathic Pain in Rats

et al. 2008

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Responses resulting from injury to the trigeminal nerve exhibit differences compared with those caused by lesion of other peripheral nerves. With the aim of elucidating the physiopathological mechanisms underlying cephalic versus extracephalic neuropathic pain, we determined the time course expression of proinflammatory cytokines interleukin-6 (IL-6) and IL-1␤, neuronal injury (ATF3), macrophage/microglial (OX-42), and satellite cells/astrocyte (GFAP) markers in central and ganglion tissues in rats that underwent unilateral chronic constriction injury (CCI) to either infraorbital nerve (IoN) (cephalic area) or sciatic nerve (SN) (extracephalic area). Whereas CCI induced microglial activation in both models, we observed a concomitant upregulation of IL-6 and ATF3 in the ipsilateral dorsal horn of the lumbar cord in SN-CCI rats but not in the ipsilateral spinal nucleus of the trigeminal nerve (Sp5c) in IoN-CCI rats. Preemptive treatment with minocycline (daily administration of 20 mg/kg, i.p., for 2 weeks) partially prevented pain behavior and microglial activation in SN-CCI rats but was ineffective in IoN-CCI rats. We show that IL-6 can upregulate OX-42 and ATF3 expression in cultured microglia and neurons from spinal cord, respectively, as well as in the dorsal horn after acute intrathecal administration of the cytokine. We propose that IL-6 could be one of the promoters of the signaling cascade leading to abnormal pain behavior in SN-CCI but not IoN-CCI rats. Our data further support the idea that different pathophysiological mechanisms contribute to the development of cephalic versus extracephalic neuropathic pain.

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Section: Cytokines Neuronal and Glial Markers In Sensory Gangliamentioning

confidence: 79%

Differential Implication of Proinflammatory Cytokine Interleukin-6 in the Development of Cephalic versus Extracephalic Neuropathic Pain in Rats

et al. 2008

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“…Interestingly, not all calbindin D-28k ϩ cells were ␤-gal ϩ , suggesting that Runx1 is not expressed in all vestibular neurons. Similarly, essentially all of the ␤-gal ϩ cells in trigeminal ganglia expressed the TrkA neurotrophin receptor, a marker of postmitotic nociceptive and thermoceptive neurons (18) (Fig. 1H).…”

Section: Expression Of Runx1 In Selected Cranial Ganglion Sensory Neumentioning

confidence: 82%

AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons

Theriault

Roy

Stifani

2004

Proc. Natl. Acad. Sci. U.S.A.

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The mechanisms that regulate the acquisition of distinctive neuronal traits in the developing nervous system are poorly defined. It is shown here that the mammalian runt-related gene Runx1 is expressed in selected populations of postmitotic neurons of the embryonic central and peripheral nervous systems. These include cholinergic branchial and visceral motor neurons in the hindbrain, restricted populations of somatic motor neurons of the median and lateral motor columns in the spinal cord, as well as nociceptive and mechanoreceptor neurons in trigeminal and vestibulocochlear ganglia. In mouse embryos lacking Runx1 activity, hindbrain branchiovisceral motor neuron precursors of the cholinergic lineage are correctly specified but then fail to progress to a more differentiated state and undergo increased cell death, resulting in a neuronal loss in the mantle layer. In contrast, the development of cholinergic somatic motor neurons is unaffected. Runx1 inactivation also leads to a loss of selected sensory neurons in trigeminal and vestibulocochlear ganglia. These findings uncover previously unrecognized roles for Runx1 in the regulation of mammalian neuronal subtype development.

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“…1C,D). In addition to all craniofacial sensory ganglia, Advillin mRNA is also found in the neurons of the mesencephalic trigeminal nuclei (Me5), which consists of neural crest-derived proprioceptive sensory neurons innervating the masseter muscles (for review, see Lazarov, 2002). Additionally, Advillin mRNA is expressed in Mo5 motoneurons (supplemental Fig.…”

Section: Resultsmentioning

confidence: 99%

Analyzing Somatosensory Axon Projections with the Sensory Neuron-SpecificAdvillinGene

Hasegawa¹,

Abbott²,

Han³

et al. 2007

J. Neurosci.

154

173

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Peripheral sensory neurons detect diverse physical stimuli and transmit the information into the CNS. At present, the genetic tools for specifically studying the development, plasticity, and regeneration of the sensory axon projections are limited. We found that the gene encoding Advillin, an actin binding protein that belongs to the gelsolin superfamily, is expressed almost exclusively in peripheral sensory neurons. We next generated a line of knock-in mice in which the start codon of the Advillin is replaced by the gene encoding human placenta alkaline phosphatase (Avil-hPLAP mice). In heterozygous Avil-hPLAP mice, sensory axons, the exquisite sensory endings, as well as the fine central axonal collaterals can be clearly visualized with a simple alkaline phosphatase staining. Using this mouse line, we found that the development of peripheral target innervation and sensory ending formation is an ordered process with specific timing depending on sensory modalities. This is also true for the in-growth of central axonal collaterals into the brainstem and the spinal cord. Our results demonstrate that Avil-hPLAP mouse is a valuable tool for specifically studying peripheral sensory neurons. Functionally, we found that the regenerative axon growth of Advillin-null sensory neurons is significantly shortened and that deletion of Advillin reduces the plasticity of whisker-related barrelettes patterns in the hindbrain.

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Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus

Cited by 253 publications

References 446 publications

Differential Implication of Proinflammatory Cytokine Interleukin-6 in the Development of Cephalic versus Extracephalic Neuropathic Pain in Rats

Differential Implication of Proinflammatory Cytokine Interleukin-6 in the Development of Cephalic versus Extracephalic Neuropathic Pain in Rats

AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons

Analyzing Somatosensory Axon Projections with the Sensory Neuron-SpecificAdvillinGene

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