Comparative anti-hyperglycemic potentials of medicinal plants

Villaseñor, Irene M.; Lamadrid, M R

doi:10.1016/j.jep.2005.08.067

Cited by 88 publications

(46 citation statements)

References 4 publications

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“…This result agree with another finding of [25] indicating that the blood glucose lowering effect of S. cumini bark extract in oral glucose fed hyperglycaemic mice occurs within 30 min from the onset of S. cumini bark extract treatment. Phyto-chemical examinations of this plant have indicated the presence of flavonoids and other polyphenolics such as acetyl oleanolic acid, tannin, gallic acid, ellagic acid, quercetin, isoquercetin, kaempferol, myricetin, flavonol glycoside, triterpenoids, saponins and anthocyanin in different concentrations [26][27][28].…”

Section: Discussionsupporting

confidence: 93%

Anti-hyperglycemic and Anti-hyperlipemia Effects of Syzygium Cumini Seed in Alloxan Induced Diabetes mellitus in Swiss Albino Mice (Mus musculus)

Sufiyan¹

2014

Medicinal Aromatic Plants

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Section: Discussionsupporting

confidence: 93%

Anti-hyperglycemic and Anti-hyperlipemia Effects of Syzygium Cumini Seed in Alloxan Induced Diabetes mellitus in Swiss Albino Mice (Mus musculus)

Sufiyan¹

2014

Medicinal Aromatic Plants

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“…With reference to the glycemia, the studies that were performed with seeds, fruit and bark of Syzygium cumini, following several different experimental patterns, demonstrated the hypoglycemic and anti-hyperglycemic effects (Achrekar et al, 1991;Ravi et al, 2004;Sharma et al, 2003;Sridhar et al, 2005;Villasenor & Lamadrid, 2006). Nevertheless, investigations carried out in Brazil have shown that the leaves and the fruits of Syzygium cumini did not have effect on diabetes (Pepato et al, 2005;Teixeira et al, 1990;Teixeira et al, 1997;Teixeira et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

The toxicity evaluation of Syzygium cumini leaves in rodents

Silva¹,

Abreu²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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This study aimed to evaluate the safety of the hydroalcoholic extract (HE) of Syzygium cumini (L.) Skeels, Myrtaceae, leaves in rodents. Acute toxicity was evaluated through the determination of a LD50 in mice and rats (up to 14 days). In mice, the oral administration (p.o.) of the HE (0.1 at 6 g/kg) did not cause any death. When administered by intraperitoneal route (i.p.) the HE (0.1 at 1 g/kg) caused death of the animals (LD50 of 0.489 g/kg). In rats, the HE (0.5, 1 and 2 g/kg, p.o.) did not cause any death, while by i.p., only the 2 g/kg dose was lethal to 67% of the animals. To evaluate chronic toxicity, groups of rats daily received the HE (0.05, 0.1 and 0.25 g/kg) through p.o., during 30, 90 or 180 days and the effects on behavior, body weight, feed consumed were measured. Histology, hematology and biochemical parameters were measured at the end of the treatment. After a 30-day treatment, the HE caused changes in some biochemical parameters. Histological examination of the liver, kidneys, lungs, heart, stomach, intestine and pancreas showed normal architecture suggesting no morphological disturbances. These data may mean that the HE of S. cumini does not exert acute or chronic toxic effects by oral administration.

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“…Various ethno-pharmacological surveys have shown that a number of medicinal plants have been used for the treatment of diabetes with various authors attesting to the efficacy of the plants in the control of both types I and II diabetes (12) . Despite the introduction of hypoglycemic agents from natural and synthetic sources, diabetes and its related complications continue to be a major medical problem (13) .…”

Section: Imentioning

confidence: 99%