Comparative antimicrobial activity of an essential oil and an amine fluoride/stannous fluoride mouthrinse in vitro

Abstract

Although laboratory studies are not necessarily predictive of clinical activity; they can help to elucidate mechanisms underlying clinical activity when the latter has been established. In a recent clinical study, an essential oil mouthrinse (Listerine Antiseptic) was shown to be significantly more effective than an amine fluoride/stannous fluoride mouthrinse (Meridol) in inhibiting supragingival plaque formation. This paper reports the results of laboratory studies comparing the antimicrobial effectiveness of these 2 mouthrinses using a kill kinetics assay and a plaque biofilm kill assay. In both assays, the essential oil mouthrinse was considerably more effective than the amine fluoride/stannous fluoride mouthrinse. These findings are consistent with the results of the clinical trial and may help to explain the observed differences in clinical activity.

Saussurea lappa inhibits the growth, acid production, adhesion, and water-insoluble glucan synthesis of Streptococcus mutans

“…* The fluoride compounds have been used in the control of the dental plaque (Guha-Chowdhury et al, 1995), but it shows the cytotoxicity if it is used at the concentration over 80 ppm (Jeng et al, 1998). In addition, several mouth rinses have been developed as the agents for prevention of dental caries (Pan et al, 1999;Marsh, 1993), but the fact that dental caries is still major cause of tooth lose is the evidence that these agents are not sufficiently effective. Therefore, development of new preventive agents for dental caries is needed.…”

Zur antimikrobiellen Wirkung von Mundspüllösungen

“…Eine zusätzliche antimikrobielle Wirkung soll durch die Kombinationen mit CHX, Metallsalzen oder Steviosid erreicht werden [14]. Gehring [15], Pan et al [30,31], Fine et al [13] und Herrera et al [22] prüften die Wirkung fluoridhaltiger MSPL in vitro. So hemmten Aminfluoride die Säureproduktion oraler Keime (S. mutans, L. casei, S. salivarius, S. sanguinis, A. viscosus, S. mitis) innerhalb von 30 min und reduzierten die Keimzahlen bei einer Konzentration von 50 ppm von 10 7 auf 10 4 .…”

Inhibitory effect of Aralia continentalis on the cariogenic properties of Streptococcus mutans

“…Several anti-plaque agents have been investigated as preventatives in the formation of dental plaque (Pan et al, 1999), but the fact that dental caries remains the major cause of tooth loss is 0378-8741/$ -see front matter © 2011 Elsevier Ireland Ltd. All rights reserved. doi:10.1016/j.jep.2011.07.015 evidence that these agents are not sufficiently effective.…”