Saussurea lappa inhibits the growth, acid production, adhesion, and water-insoluble glucan synthesis of Streptococcus mutans

Polyphenols, oral health and disease: A review

“…Eight studies consistently report -one of them non significantly -that plant extracts inhibit glucosyltransferases (GTFs) activity and insoluble glucan synthesis [105][106][107][108][109][110][111][112] ; 10 studies, with heterogeneous designs, report adherence inhibition on hard surfaces 106,[108][109][110][111][112][113][114][115][116] ; three of the four studies investigating the inhibition of acid production from sucrose or glucose report this effect, 106,112,117 while one does not. 113 Eight studies report bacteriostatic activity against mutans streptococci [105][106][107][110][111][112]114,118 and one does not, 113 while one study reports bactericidal activity 119 and another does not. 109 In addition, plant extracts induce the downregulation of a series of enzymes essential for Streptococcus mutans metabolism, such as those responsible for amino-acid, carbohydrate, lipid and nucleotide syntheses and for translation.…”

Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant

“…The inhibitory effects of the ethanol extract of Saussurea lappa on the growth, acid production, adherence, and water-insoluble glucan synthesis of Streptococcus mutans were examined (Yu et al, 2006). The growth and acid production of Streptococcus mutans were significantly inhibited by the presence of ethanol extract of Saussurea lappa (0.5-4 mg/ml).…”

The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans

“…Many studies have shown that some natural products can interfere with survival and virulence factors of mutans streptococci (Ooshima et al, 1998;Song et al, 2006;Tsai, Tsai, & Ho, 2007;Xiao et al, 2007;Yu, Lee, Lee, Kim, & You, 2007). Remarkable anticariogenic potency was also observed for natural bioactive compounds (Duarte et al, 2006;Koo et al, 2002).…”