Comparative Antimicrobial Effectiveness of Two Medicated Soaps with Herbal Soap from <i>Morinda morindoides </i>(Rubiaceae) against Skin Pathogens

Abstract

In present study two medicated soaps namely Pharmaderm and Micoderme and herbal soap Morinda formulated with fat extracted from leaves of Morinda morindoides (Rubiaceae) were investigated for their antimicrobial activities against some clinical strains for skin.diseases. The purpose of this study was to verify and compare their antimicrobial effectiveness. Agar broth dilution method with Sabouraud and Mueller-Hinton at serial concentrations of soaps ranging from 62.50 to 3.9 mg/ml and agar plate method were used to determine antimicrobial parameters. All strains tested were inhibited significantly (p < 0.05) by different types of soaps with minimal fungicidal concentration (MFC) ranging from 62.50 -7.81 mg/ml and minimal bactericidal concentration (MBC) between 31.25 -7.81 mg/ml. Soap Micoderme exhibited highest antimicrobial effectiveness with MFC varying from 7.81 to 31.25 mg/ml and MBC of 15.62 mg/ml. Soaps Morinda and Pharmaderm showed similar antibacterial activities with MBC of 31.25 mg/ml. Soap Morinda with MFC of 31.25 mg/ml was more effectiveness than soap Pharmaderm (MFC of 62.50 mg/ml) against all fungi. T. mentagrophytes was most sensitive fungi whereas C. albicans was least strain in presence of tested soaps. S. aureus was the most resistant among testing bacteria. This study demonstrated that hence buttressing the information written on two medicated soaps labels they possess antimicrobial activity and fat of M. morindoides incorporated at 10 % on basic soap formulation gave an effective antimicrobial power to soap Morinda. Further investigation was to clarify the phytochemical groups of herbal fat responsible for antimicrobial power of soap Morinda.

Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides

“…The traditional use of the leaves of this plant in other African countries has been described [8]. The fractions obtained from the leaf extract by solvent partition have been reported to possess antiplasmodial activity [9], anti-microbial activities against some skin diseases [10], and anti-fungal activity [11] by in vitro assay. Extensive phytochemical research on the leaves has identi ed avonoids [12], iridoids [13,14], and anthraquinones [15], and on the roots has identi ed ketosteroid [16].…”

“…)[35]; two megastigmanes, (+)-(6R,9S)-blumenol C (8)[36] and (+)-(6S,9R)-blumenol B (9)[37]; and two avonol 3-O-glycosides, astragalin(10) [38] and rutin(11) [39]. Moreover, in our preliminary study, the peak of oleanolic acid(12) -for which anti-malarial activity has been reported[40,41] -was detected (m/z 457.3662 [M + H] + and 455.3554 [M-H] − ) in both MeOH and EtOH extracts in the less polar part by LC/MS.…”