Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol

Dugasani, Swarnalatha; Pichika, Mallikarjuna Rao; Nadarajah, Vishna Devi; Balijepalli, Madhu Katyayani; Tandra, Satyanarayana; Korlakunta, Jayaveera Narsimha

doi:10.1016/j.jep.2009.10.004

Cited by 593 publications

(404 citation statements)

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“…The principal active component of ginger (Zingiber officinale Rosc., Zingiberaceae), 6-gingerol, is a Saranya et al phenolic compound. 6-Gingerol and its derivatives have wide range of medicinal properties like antimicrobial, antifungal, antiviral, antioxidant, anti-inflammatory, and anticancer activities (Bartley et al 2000;Dugasani et al 2009;Grzanna et al 2005;Shukla & Singh 2007). Turmeric (Curcuma longa L. Zingiberaceae), a widely studied Indian spice, is used in traditional medicines from ancient times.…”

Section: Introductionmentioning

confidence: 99%

Turmeric and cinnamon dominate in antioxidant potential among four major spices

Saranya¹,

Sulfikarali²,

Chindhu³

et al. 2017

J Spices Aromatic Crops

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Antioxidant activity of sequential extracts of black pepper, ginger, turmeric and cinnamon was determined by DPPH assay, phosphomolybdate method and ferric reducing power method and compared with that of the synthetic antioxidant BHA. The results revealed that methanol extract of cinnamon has highest antioxidant potential followed by chloroform extract of turmeric. The antioxidant potential was also correlated with total phenol content.

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Section: Introductionmentioning

confidence: 99%

Turmeric and cinnamon dominate in antioxidant potential among four major spices

Saranya¹,

Sulfikarali²,

Chindhu³

et al. 2017

J Spices Aromatic Crops

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“…The principal components of the non-volatile comprise of the polyphenolic compounds such as 6-gingerol, 6-shogaol, 8-gingerol, and 10-gingerol. 6-Gingerol being the most abundant and has been widely investigated for its many pharmacological activity such as anti-inflammatory, analgesic, antipyretic, chemopreventive, and antioxidant properties (Dugasani et al, 2010;Ippoushi et al, 2003;Koo et al, 2001;Kundu & Surh, 2009;Suekawa et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of the standardized extract ofZingiber officinaleon myocardium against isoproterenol-induced biochemical and histopathological alterations in rats

Amran

Jantan

Dianita

et al. 2015

Pharmaceutical Biology

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Context: Ginger [Zingiber officinale Roscoe. (Zingiberaceae)] has been universally used as a spice as well as for its health benefits. Objective: The present study evaluates the protective effect of the standardized extract of ginger against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Materials and methods: Wistar rats were pretreated orally with three doses of standardized ginger extract (100, 200, and 400 mg/kg of body weight) or propranolol (5 mg/mL) for 28 d prior to ISO (85 mg/kg) induced MI in two doses on days 29 and 30. The rats were sacrificed 48 h after the first induction; serum and hearts were collected for biochemical and histopathological analysis. Results: Gingerols and shogaols were identified and quantitatively analyzed in the extracts using validated reversed phase HPLC methods. Pretreatment with ginger extract at 400 mg/kg showed a significant decrease (p50.05) in all the cardiac enzyme activities, i.e., cardiac troponin I (cTnI) (0.57 ng/mL), creatine kinase MB isoenzyme (CK-MB) (10.34 pg/mL), lactate dehydrogenase (LDH) (115.22 U/L), alanine transaminase (ALT) (15.79 U/L), and aspartate transaminase (AST) (46.72 U/L) when compared with ISO-control rats. There were significant rises (p50.05) in the activity of glutathione peroxide (GPx) (53.16 U/L), catalase (CAT) (210.41 U/L), and superoxide dismutase (SOD) (280.89 U/mL) of the pretreated rats when compared with the ISO-control. Histopathological examination showed an improvement in membrane cell integrity in pretreated rats compared with untreated rats. Conclusion: The ethanol extract of ginger exhibited cardioprotective potential in treating myocardial injury following ISO administration.

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“…22 Thus, for the design of the novel shogaol-huprine hybrids, the selection of the optimal length of the tether, which was to link the phenolic ring of the shogaol unit and the huprine moiety, was carried out by investigating the binding mode of the hybrids within AChE. To this end, docking calculations were performed using three models of the human AChE (hAChE), which differ in the orientation of Trp286 in the peripheral anionic site (PAS) (see section 4.3).…”

Section: Binding Mode Within Human Ache: Molecular Modelling Studiesmentioning

confidence: 99%

“…It has been recently reported that [6]shogaol exhibits potent antioxidant and anti-inflammatory activities, its enone moiety being essential for these activities. 22,23 Interestingly, [6]-shogaol enhances antioxidant defense mechanisms both in cell cultures and in mice 24 and counteracts the hydrogen peroxide-induced increase of reactive oxygen species (ROS) in HT22 cells, an in vitro model of hippocampal cholinergic neurons. 25 Herein, we describe the design, synthesis, and pharmacological evaluation of a short series of multitarget antiAlzheimer hybrid compounds that combine a unit of the highly potent AChE inhibitor huprine Y (2, Fig.…”

Section: Introductionmentioning

confidence: 99%