Comparative antiproliferation of human prostate cancer cells by ethanolic extracts of two groups of Brazilian propolis

Moraes, Cleber Silveira; Daugsch, Andreas; Li, Hongzhen; Rhim, Johng S.; Park, Yong Kun

doi:10.1590/s0101-20612010000200038

Cited by 10 publications

(8 citation statements)

References 12 publications

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“…The antiproliferative properties of propolis from some parts of the world (Chilean, Turkish, Brazil, etc.) have been reported, however much is needed regarding their molecular mechanisms of action 18‐20 . Recently Zingue et al 21 reported the antiproliferative effects of the ethanol extract of Cameroonian propolis in the prostate but our survey revealed there has been no report on its effect against breast cancer yet.…”

Section: Introductionmentioning

confidence: 74%

The antimammary tumor effects of ethanolic extract of propolis from Adamawa region (Cameroon) are by apoptosis via reactive oxygen species‐mediated mitochondrial pathway

Zingue

Cisilotto

Fogang

et al. 2021

Environmental Toxicology

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Identification of novel natural treatment to combat cancer is a current need. This study was aimed at assessing the anticancer effects of ethanol‐extracted Cameroonian propolis (EEP). The antitumor effect of EPP was evaluated in vitro by measuring; cell viability, cell cycle, cell death mechanism, cell migration/invasion, reactive oxygen species (ROS), mitochondrial potential (ΔΨm), caspase activity, and apoptosis‐regulating proteins (Bcl‐2 and Bcl‐XL) in cell lines. In vivo, the effect of EEP against 7,12 dimethylbenz(a)anthracene (DMBA)‐induced breast tumorigenesis in rats was assessed. EEP was found to induce cytotoxicity against ER negative MDA‐MB‐231 breast cancer cells by activating apoptosis through ROS‐mediated mitochondrial pathway. The extract equally triggered caspase‐3 and caspase‐9, increment of ROS level, disruption of ΔΨm and down‐regulation of Bcl‐XL and Bcl‐2 proteins. Besides, EPP prevented migration and invasion activities by inhibiting MMP‐2 activity. At all doses it prevented breast tumor incidence (20% in EEP 150 mg/kg vs 70% in DMBA) as well as tumor burden. Tumor sections from EEP‐treated rats showed middle proliferation of mammary ducts with weak inflammatory responses. In summary, Cameroonian propolis exhibited antimammary tumor effects via the intrinsic pathway of apoptosis.

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Section: Introductionmentioning

confidence: 74%

The antimammary tumor effects of ethanolic extract of propolis from Adamawa region (Cameroon) are by apoptosis via reactive oxygen species‐mediated mitochondrial pathway

Zingue

Cisilotto

Fogang

et al. 2021

Environmental Toxicology

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“…This is in confirmation with results already obtained with propolis worldwide on different cancer cell lines. Indeed, many reports have shown that the ethanolic extract of Brazilian red propolis induced a very strong inhibition of human prostate cancer cells RC‐58T/h/SA#4 (Moraes et al., 2010). Chilean propolis has been shown to inhibit the proliferation of DU145 prostate cancer cells, KB epidermoid cancer cells and Caco‐2 colorectal adenocarcinoma cells (Russo et al., 2004).…”

Section: Discussionmentioning

confidence: 99%

“…The in vivo and in vitro antiproliferative effects of propolis from different regions (Chilean, Turkish, Brazil, etc.) have been demonstrated but the molecular mechanisms involved are poorly described (Moraes, Daugsch, Li, Rhim, & Park, 2010; Russo et al., 2004; Turan et al, 2015). This variation in composition of propolis which is dependent on edaphological factors makes the propolis from unexplored regions a plausible target for scientific study (Ahn et al., 2007; Popova, Chinou, Marekov, & Bankova, 2009).…”

Section: Introductionmentioning

confidence: 99%

Ethanol‐extracted Cameroonian propolis: Antiproliferative effects and potential mechanism of action in prostate cancer

et al. 2020

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Benign prostatic hyperplasia (BPH) is the most common urological disease in men, affecting about 33% of men in their 60 years (De Nunzio et al., 2011). With regard to prostate cancer, it is the second leading cause of cancer deaths in men after lung cancer (Siegel, Miller, & Jemal, 2018). BPH and prostate cancer are formed in different areas of the prostate and coexist in the same area only in 20% of cases (De Nunzio et al., 2011). They are considered as chronic diseases with early initiation and slow progression, and several risk factors are associated with them including obesity, poor diet, tobacco, radiation, environmental pollutants, lack of physical activity and ageing (Patel, 2016). The conventional therapy for BPH involves two main drug classes: alpha blockers and 5α-reductase inhibitors (Füllhase & Schneider, 2016), while chemotherapy and hormone therapy are utilised to fight against prostate cancer (Adsul et al., 2015). Unfortunately, these drugs are still limited because of their side effects, tumour resistance and high cost

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“…Chemical structure of compounds with important biological activities of propolis cerebral), generadas por la liberación de radicales libres. Los resultados mostraron que la administración aguda de CAPE y α-tocoferol suprimió la isquemia inducida por la peroxidación lipídica y el daño cerebral, encontrándose que CAPE ofrece una mayor ventaja terapéutica que el α-tocoferol;Moraes et al (2010), evaluaron muestras de propóleos brasileños para conocer el efecto antiproliferativo sobre tumores malignos primarios (RC-58T/h/SA#4), derivados de células de cáncer prostático humano. Por otra lado, Li-Chang et al…”

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Mecanismos Involucrados en La Actividad Antioxidante Y Antibacteriana Del Propóleos

Vargas-Sánchez

Torrescano-Urrutia

Mendoza–Wilson

et al. 2014

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El propóleos es un producto elaborado por las abejas, que se caracteriza por poseer propiedades antioxidantes y antimicrobianas, las cuales son atribuidas a la presencia de compuestos polifenólicos, principalmente flavonoides. Estos compuestos son de bajo peso molecular y en su estructura química contienen un número variable de grupos hidroxilos. Varios investigadores han reportado que los mecanismos antioxidantes propuestos para estos grupos son mediante secuestro de radicales libres, o actuando como substrato para radicales, tales como superóxido e hidroxilo, y quelación de iones metálicos. Mientras que el mecanismo antimicrobiano involucra la inhibición de ácidos nucleicos y degradación de la membrana citoplasmática.

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Comparative antiproliferation of human prostate cancer cells by ethanolic extracts of two groups of Brazilian propolis

Cited by 10 publications

References 12 publications

The antimammary tumor effects of ethanolic extract of propolis from Adamawa region (Cameroon) are by apoptosis via reactive oxygen species‐mediated mitochondrial pathway

The antimammary tumor effects of ethanolic extract of propolis from Adamawa region (Cameroon) are by apoptosis via reactive oxygen species‐mediated mitochondrial pathway

Ethanol‐extracted Cameroonian propolis: Antiproliferative effects and potential mechanism of action in prostate cancer

Mecanismos Involucrados en La Actividad Antioxidante Y Antibacteriana Del Propóleos

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