Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers

Murphy, Dennis L.; Mueller, Edward A.; Hill, James L.; Tolliver, Teresa J.; Jacobsen, Frederick M.

doi:10.1007/bf00444705

Cited by 201 publications

(96 citation statements)

References 34 publications

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“…5-HTID, 5-HTzA. 5-HTzc, and 5-HT3 but also to uz-adrenoreceptors and weakly to dopaminergic receptors (Murphy et al 1989). In addition.…”

Section: Use Of Direct Agonistsmentioning

confidence: 90%

“…the development of 5-HT agonists such as m-CPP has made possible the exploration of 5-HT receptor function in humans (Mueller et al 1985;Murphy et al 1989). Studies have reported that both oral and intravenous administration of m-CPP lead to signiflcant Increases in PRL.…”

Section: Use Of Direct Agonistsmentioning

confidence: 99%

“…• Three questionnaires were used to assess the psychologieal and somatlc changes associated with flesinoxan infusions: the Bipolar Profile of Mood States (bip-POMS) (McNair et al 1988), the NIMH Self-Rating Scale (Murphy et al 1989) and a somatic symptom checklist. The bip-POMS is highly sensitive to non-clinical changes in mood states and and plus 120 min respectively, in the dose-response study.…”

Section: Assessment Ofmood and Other Psychological Responsesmentioning

confidence: 99%

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Serotonin1A Receptor Activation by Flesinoxan in Humans Body Temperature and Neuroendocrine Responses

Seletti

Benkelfat

Blier

et al. 1995

Neuropsychopharmacology

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“…5-HTID, 5-HTzA. 5-HTzc, and 5-HT3 but also to uz-adrenoreceptors and weakly to dopaminergic receptors (Murphy et al 1989). In addition.…”

Section: Use Of Direct Agonistsmentioning

confidence: 90%

Section: Use Of Direct Agonistsmentioning

confidence: 99%

Section: Assessment Ofmood and Other Psychological Responsesmentioning

confidence: 99%

See 1 more Smart Citation

Serotonin1A Receptor Activation by Flesinoxan in Humans Body Temperature and Neuroendocrine Responses

Seletti

Benkelfat

Blier

et al. 1995

Neuropsychopharmacology

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“…These effects are probably mediated through postsynaptic 5-HT1A and 5-HT2A/5-HT2C receptors (Meltzer and Maes 1995). mCPP administration increases body temperature (Murphy et al 1989). These effects are probably mediated through 5-HT2 receptors, because stimulation of 5-HT1A receptors in man and rodents causes hypothermia (Gudelsky et al 1986;Lesch et al 1990), whereas stimulation of 5-HT2 receptors induces hyperthermic effects (Gudelsky et al 1986).…”

mentioning

confidence: 99%

Lower Baseline Plasma Cortisol and Prolactin together with Increased Body Temperature and Higher mCPP-Induced Cortisol Responses in Men with Pedophilia

Maes

2001

Neuropsychopharmacology

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There is some evidence that hormonal and serotonergic alterations may play a role in the pathophysiology of paraphilias. The aims of the present study were to examine: 1) baseline plasma cortisol, plasma prolactin, and body temperature; and 2) cortisol, prolactin, body temperature, as well as behavioral responses to metachlorophenylpiperazine (mCPP) The sexual abuse of children (pedophilia) represents a significant proportion of about 25% of all sexual offences (Moller and Bier-Weiss 1995). Between 100,000 and 500,000 children in the United States are thought to be sexually molested annually (Fuller 1989). Pedophilia is one of the sexual deviation disorders or paraphilias, which are diagnosable psychiatric syndromes characterized by recurrent fantasies about deviant sex, intense associated cravings, and stereotypic behavioral responses (Berlin and Meinecke 1981). The DSM-IV (APA 1994) describes the paraphilias as an impulse control disorder (ICD) (Cosyns 1999). Indeed, patients with paraphilias experience tension or arousal before committing the sexual act, experience pleasure during the act and feel a release of tension after the act (Cosyns (Greenberg et al. 1996).Although there is a substantial evidence in the historical and anthropological record of pedophilia, there has been little research on the biological pathophysiology of pedophilia. Alterations in the metabolism of serotonin (5-HT) may play a role in the pathophysiology of paraphilias (Kafka 1997). 1) 5-HT is involved in male sexual behavior; 2) serotonergic agents, such as selective 5-HT reuptake inhibitors (SSRIs), can ameliorate paraphilic sexual behaviour (review: Balon 1998; Greenberg et al. 1996;Zonana and Norko 1999); and 3) there is an extensive number of clinical and animal studies supporting the hypothesis that a dysfunction of the 5-HT neurotransmitter system is an important factor in the underlying pathology of impulse control disorders (ICD) and aggression/violence (Linnoila et al. 1983;Markowitz and Coccaro 1995;Kavoussi et al. 1997;McElroy et al. 1995;Coccaro 1999).A number of studies report lower CSF 5-hydroxyindole-acetic acid (5-HIAA) in ICD and aggressive patients, such as impulsive offenders and fire setters (review: Virkkunen et al. 1989;Coccaro 1999). The prolactin responses induced by D-L-fenfluramine (an indirect 5-HT agonist which releases 5-HT) are significantly and inversely related with measurements of aggression (Coccaro et al. 1989;O'Keane et al. 1992). Several authors found inverse relationships between platelet 5-HT transporter binding and impulsivity/aggression (Simeon et al. 1992;Coccaro et al. 1996). Patients with episodic aggression show a significantly lower platelet [ 3 H]-5-HT uptake than controls (Brown et al. 1989). Coccaro et al. (1997) described a positive correlation between the number of platelet 5-HT2A receptor sites and measures of aggression, in personality-disordered patients. Tryptophan depletion in subjects with preexisting aggressive traits induces increased aggression (Cleare and Bond 1995). The ...

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“…At 13:00, an intravenous catheter was placed in an antecubital vein for repeated blood sampling. At 14:30, 2 to 4 capsules of either m-CPP (0.4 mg/kg), ipsapirone (0.3 mg/kg), or placebo were administered orally.Behavioral effects were assessed using the Acute Panic Inventory (Dillon et al 1987) and a modified version of the NIMH Self-Rating Scale (Murphy et al 1989) that comprises 24 questions and defines six subscales of behavioral change: anxiety, activation-euphoria, altered self-reality, depressive affect, dysphoria, and functional deficit. Behavioral ratings were completed at 14: 00, 14:30, 15:00, 15:30, 16:00, 16:30, 17:30, and 18:30.…”

mentioning

confidence: 99%

Decreased Neuroendocrine Responses to Meta-Chlorophenylpiperazine (m-CPP) but Normal Responses to Ipsapirone in Marathon Runners

Broocks

Meyer²,

George

et al. 1999

Neuropsychopharmacology

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Several clinical studies suggest antidepressive and anxiolytic effects of regular aerobic exercise. To study the effects of exercise on central serotonergic receptor sensitivity, we performed neuroendocrine challenges using oral doses of meta-chlorophenylpiperazine (m-CPP, 0.4 mg/ kg), ipsapirone (0.3 mg/kg) and placebo in 12 marathon runners and 12 healthy controls not practicing regular exercise. After administration of the nonselective serotonergic agonist m-CPP, which exerts a number of wellreproducible effects mainly by means of its action on 5-HT Meta-chlorophenylpiperazine (m-CPP); Ipsapirone Several studies of healthy volunteers have shown a positive effect of endurance training on anxiety, depressive symptoms, self-esteem, concentration, sexual satisfaction, and stress tolerance (de Coverley Veale 1987;Farmer et al. 1988;Hughes 1984;Lennox et al. 1990;MacMahon 1990;Sothman et al. 1992). There is also some evidence that exercise is effective against mild-to-moderate depression and against anxiety disorders (Doyne et al. 1987;Greist et al. 1979;Martinsen et al. 1985;McCann and Holmes 1984;Pappas et al. 1990;Sexton et al. 1989). Research in sports medicine has focused on physiological and immunological consequences of exercise, and little is known about changes in central neurotransmitter function associated with acute or regular endurance training.Several lines of evidence suggest that motor activity affects central serotonin metabolism. In the cerebrospinal fluid of depressed patients, the concentration of the serotonin metabolite 5-HIAA was significantly higher after 4 hours of motor activity than in the same patients after bed rest (Post et al. 1973). Aerobic exercise causes a rise of free fatty acids Fischer et al. From the Department of Psychiatry, University of Göttingen, Göt-tingen, Germany (AB, DM, BB, GH, UB, ER), the Department of Neurology (AG), University of Würzburg, Würzburg, Germany; the Department of Clinical Pharmacology (CHG), Department of Sports Medicine (UH-V), University of Göttingen, Göttingen, Germany; Institute of Sports and Preventive Medicine (TM), University of Saarbrücken, Saarbrücken, Germany.Address correspondence to: Dr. A. Broocks, The Department of Psychiatry, University of Göttingen, von-Siebold-Strasse 5, D-37075 Göttingen, Germany.Received 28 October 1997; revised 12 March 1998; accepted 13 April 1998. N EUROPSYCHOPHARMACOLOGY 1999 -VOL . 20 , NO . 2 Decreased Serotonergic Responsiveness in Marathon Runners 151 1991), which displace free tryptophan (TRP) from its plasma-protein-binding sites (Blomstrand et al. 1988;Chaouloff et al. 1986). This leads to an increase of free TRP in relation to other large neutral amino acids (LNAA) (Chaouloff et al. 1989). Because the TRP influx into the brain correlates with the TRP/LNAA plasma ratio (Fernstrom and Wurtman 1971;Wurtman and Fernstrom 1976), exercise leads to a higher precursor availability in the brain, which, in turn, stimulates 5-HT synthesis (Broocks et al. 1989;Chaouloff 1997). Data from animal studies show th...

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Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers

Cited by 201 publications

References 34 publications

Serotonin1A Receptor Activation by Flesinoxan in Humans Body Temperature and Neuroendocrine Responses

Serotonin1A Receptor Activation by Flesinoxan in Humans Body Temperature and Neuroendocrine Responses

Lower Baseline Plasma Cortisol and Prolactin together with Increased Body Temperature and Higher mCPP-Induced Cortisol Responses in Men with Pedophilia

Decreased Neuroendocrine Responses to Meta-Chlorophenylpiperazine (m-CPP) but Normal Responses to Ipsapirone in Marathon Runners

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