Comparative assessment of Cranberry and Chlorhexidine mouthwash on streptococcal colonization among dental students: A randomized parallel clinical trial

Abstract

Background:Chlorhexidine gluconate mouthwash has earned an eponym of the gold standard against oral infections, but with certain limitations. There is no effective alternative to Chlorhexidine. Cranberry is known to inhibit bacterial adhesion in various systemic infections and acts as a strong antioxidant. However, it is less explored for its dental use. Hence, there is a need to evaluate its effect against oral infections.Aim:The aim was to compare the efficacy of 0.2% Chlorhexidine mouthwash with 0.6% Cranberry mouthwash on Streptococcus mutans.Materials and Methods:This was a double-blind, randomized parallel group clinical trial. Total sample of 50 subjects, aged 18–20 years, were randomly divided into two groups, Group A (25) and Group B (25) were given 10 mL of Chlorhexidine mouthwash and Cranberry mouthwash twice daily, respectively, for 14 days each. The plaque samples, which were taken from the subjects on 1st day and 14th day, were inoculated on blood agar plates and incubated at 37°C for 24–48 h. Number of streptococcal colony forming units were calculated using digital colony counter. The data were subjected to paired t-test and unpaired t-test at a 5% significance level.Results:(1) Chlorhexidine mouthwash showed 69% reduction whereas Cranberry mouthwash showed 68% reduction in S. mutans count. (2) No significant difference was seen between Chlorhexidine and Cranberry mouthwash on streptococci.Conclusion:Cranberry mouthwash is equally effective as Chlorhexidine mouthwash with beneficial local and systemic effect. Hence, it can be used effectively as an alternative to Chlorhexidine mouthwash.

Comparative evaluation of grape seed and cranberry extracts in preventing enamel erosion: An optical emission spectrometric analysis

“…in 2017 have found that CE at a concentration of 600 mg produced the maximum zone of inhibition against Streptococcus mutans . [ 11 ]…”

A Prospective, Double-Blind, Randomized, Controlled Clinical Trial in the Gingivitis Prevention with an Oligomeric Proanthocyanidin Nutritional Supplement

“…Besides the anti-inflammatory effect, OPCs have shown antimicrobial effect, reported by further studies [ 10 – 16 , 23 , 25 ]. This property also justifies testing the effectiveness of the OPCs in periodontal disease.…”

“…These results lead us to suspect that this supplement certainly has antimicrobial effect, since the gingival bleeding index and Silness and Löe index were lower even in the presence of more dental plaque, so the nature of the plaque must be modified, possibly because of a change in the pH or by a different bacterial composition. In March 2015, Mahesh et al published in the Contemporary Clinical Dentistry a randomized parallel clinical trial comparing a 0.2% chlorhexidine gluconate mouthwash versus a 0.6% cranberry mouthwash on Streptococcus mutans in 50 subjects, obtaining similar results in the colonisation of this bacteria in the plaque [ 25 ]. This study confirms the results obtained in our clinical trial, in which we hypothesised that the plaque could be different because of the minor inflammation of the periodontal tissue.…”

“…Although in vitro studies published about the interaction between the OPCs and pathogens in the oral cavity have had very good results, there are no publications with the appropriate design to assess the clinical efficacy of OPCs in gingival disease in human, except an article published in 2015 comparing the chlorhexidine and the cranberry mouthwash [ 22 – 25 ].…”

Der Helfer aus den Anden

“…Es gibt bereits einzelne Studien, in denen man untersucht hat, wie oligomere Proanthocyanidine auf Biofilme wirken. Oligomere Proanthocyanidine können das Anhaften von Bakterien hemmen, wodurch diese nur erschwert einen Biofilm bilden können [6,7]. Es ist noch nicht nachgewiesen, dass auch die in Ratanhia enthaltenen Proanthocyanidine ähnliche Effekte haben.…”