Comparative assessment of intraocular inflammation following standard or heavy silicone oil tamponade: a prospective study

Semeraro, Francesco; Russo, Andrea; Morescalchi, Francesco; Gambicorti, Elena; Vezzoli, Sara; Parmeggiani, Francesco; Romano, Mario R.; Costagliola, Ciro

doi:10.1111/aos.13830

Cited by 39 publications

(48 citation statements)

References 23 publications

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“…Previous studies have reported that the use of Densiron ® 68 results in higher IOP levels, and more cases of inflammatory reaction and emulsification than Oxane ® HD because of its lower viscosity (1400 cSt for Densiron ® 68 vs. 3300 cSt for Oxane ® HD at 25°C. 26,27,28 Nevertheless, in our study Densiron ® 68 and Oxane ® HD had similar, low complication rates. Two steps of the procedure could explain these low complication rates: first, all patients received a subconjunctival injection of 4 mg dexamethasone at the end of surgery, which reduces postoperative inflammation, and second, the ocular cavity was completely filled with HDSO.…”

Section: Discussionsupporting

confidence: 42%

Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment

Keilani¹,

Augstburger²,

Robin³

et al. 2019

tjo

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Objectives: To compare biochemical outcomes, effectiveness, and tolerance of two high-density silicone oils (HDSOs), silicone oil-RMN3 (Oxane ® HD) and silicone oil-Densiron-68 (Densiron ® 68), for the management of complicated retinal detachment (RD) associated with inferior proliferative vitreoretinopathy (PVR). Materials and Methods: This was a retrospective, single-centre, comparative case series of 23 patients treated between September 2014 and June 2016. The main inclusion criteria were RD with inferior PVR receiving Oxane ® HD or Densiron ® 68 following pars plana vitrectomy. The main outcome measures were anatomical success, rate of RD recurrence, and best-corrected visual acuity (BCVA) at 6 months. Secondary outcomes were short-term complications. Results: Twenty-three eyes were included: 16 eyes with Densiron ® 68 tamponade and 7 eyes with Oxane ® HD tamponade. Anatomical success under HDSO was significantly higher in the Densiron ® 68 group (100%) than in the Oxane ® HD group (42.8%) (p=0.0455). Recurrent RD was observed in 42.8% of eyes under Oxane ® HD, but in none of the patients under Densiron ® 68 (p=0.001). Six months after surgery, mean BVCA values (+/-standard deviation) with Densiron ® 68 and Oxane ® HD were 0.83±0.62 logMAR and 1.81±0.65 logMAR, respectively. BVCA was significantly better in the Densiron ® 68 group (p=0.006). No significant differences were observed with regard to intraocular pressure, emulsification, or intraocular inflammation. Conclusion: Densiron ® 68 appears to be more effective than Oxane ® HD for the management of RD associated with PVR. A randomized, controlled, interventional study is needed to demonstrate this difference.

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Section: Discussionsupporting

confidence: 42%

Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment

Keilani¹,

Augstburger²,

Robin³

et al. 2019

tjo

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“…SO unleashes a foreign body-like reaction in the trabecular meshwork with SO microbubbles phagocytized by macrophages [ 67 , 68 , 69 , 70 , 71 , 72 ]. Heavy SO (HSO) may result in a higher inflammatory reaction, probably due to its increased emulsification tendency compared to PDMS [ 73 , 74 ]. These etiological pathways lead to an open angle mechanism that underlies OH and is usually managed medically [ 2 , 4 , 37 ].…”

Section: Early Post-operative Ocular Hypertensionmentioning

confidence: 99%

“…Ocular inflammation is one of the factors involved in IOP elevation during silicone oil endotamponade [ 74 ]. Although in some studies inflammation rate seems to be proportional to the duration of tamponade application [ 4 , 74 , 100 ], evidence suggests that this reaction may likely persist after SO removal and may contribute to the IOP rise [ 101 , 102 ]. Percentages of ocular inflammation described in the literature range from 3 to 41% within 4 months from silicone oil injection [ 103 ].…”

Section: Late Onset Silicone Oil-induced Glaucomamentioning

confidence: 99%

“…There are several mechanisms responsible for intermediate and late-onset glaucoma following the use of SO during retinal surgery, including migration of SO in the anterior chamber with possible infiltration of the trabecular meshwork by emulsified SO bubbles [ 11 , 37 , 53 , 73 , 79 , 98 , 103 , 149 , 150 ]; chronic inflammation [ 4 , 67 , 68 , 69 , 70 , 71 , 72 , 74 , 100 , 101 , 102 , 151 , 152 , 153 , 154 , 155 ]; synechial angle closure [ 11 , 53 , 78 , 156 ], rubeosis iridis [ 50 , 79 , 95 , 157 ], and unknown preexisting open-angle glaucoma [ 37 , 50 , 54 ]. The most common mechanism for chronic postoperative increase of IOP seems to be the secondary open-angle glaucoma caused by the blockage of trabecular meshwork [ 73 ].…”

Section: Late Onset Silicone Oil-induced Glaucomamentioning

confidence: 99%

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Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review

Nicolai

Lassandro

Franceschi

et al. 2020

Vision

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Silicone oil represents the main choice for intraocular tamponade in cases of complicated retinal detachment surgery. The intraocular pressure of an eye filled with silicone oil could increase, driven by a variety of different forces, according to several mechanisms. Two main conditions have been highlighted, depending on the onset: early hypertension or late glaucoma. The different types of silicone oils and their physico-chemical properties are varied and may play a role in the determination of intraocular pressure rise. The current body of literature allows for the illustration and categorization of the incidence and risk factors, as well as the pathogenesis and the management of the early postoperative hypertension subtended by an open- and closed-angle, along with the late onset silicone oil-induced glaucoma. Understanding the leading actors on the stage of ocular pressure elevation concurrently with silicone oil application for retinal surgery could help in guiding the timely and appropriate course of treatment.

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“…Therefore, in order to improve the healing of the underlying retinal tears, there are two heavy silicone oil products approved as intraocular tamponades for clinical use in Europe, Oxane HD (siliconefluorinated paraffin mixture) and Densiron (silicone-heavy water mixture) [2] . Heavy silicone oil solves the problem of the lower retinal detachment in some extent and help for the retina reattachment, whereas many of its complications have also been observed in clinical applications, such as cataract, intraocular light-to-moderate inflammatory response and increased intraocular pressure, etc [3] .Therefore, vitreous tamponades with good biocompatibility, stable properties, and no recipient limitation, should be developed to effectively press the retinal tears with different orientations [4] .…”

Section: Introductionmentioning

confidence: 99%

Effect on rabbits’ intraocular structure by cross-linked hyaluronic formations as vitreous substitute

Gong¹,

Chen

et al. 2019

Preprint

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Purpose: To observe the effects of cross-linked hyaluronic hydrogel on retina struct and intraocular biocompatibility in rabbits. Methods: the polymer-derived hyaluronic acid which was formed by UV light cross-linked with N-vinyl-pyrrolidone. Free hyaluronic acid levels were detected by spectrophotometric method. Vitrectomy was then performed in the rabbits, and then cross-linked hyaluronic acid hydrogels of different concentrations were injected. Intraocular pressure measurements, cornea check-up, and B-ultrasound examination were performed during the follow-up period. After six weeks’ follow-up, the rabbits were sacrificed, and both eyes were removed. The eyeballs were fixed for HE staining, and the polymer materials were observed under electron microscopy. Results: The synthetic hydrogel present a transparent substance with a refractive index similar to that of the human vitreous body, which also had sufficient viscosity and elasticity for intraocular usage by rheological measurements. The results of the free hyaluronic acid test showed that the hydrogel had little degrade within one month. The results of the histology, intraocular pressure, B-ultrasound and retinal ultrastructure suggested that cross-linked hyaluronic acid hydrogel had superior tissue biocompatibility intraocular for six weeks. Conclusions: Hyaluronic acid-based cross-linked biopolymers had good biocompatibility in rabbit, which also shown promising potential as vitreous substitutes in clinical practice.

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Comparative assessment of intraocular inflammation following standard or heavy silicone oil tamponade: a prospective study

Abstract: Although both HSO and PDMS yielded favourable success rates in the surgical treatment of complicated retinal detachments, HSO triggered a more severe inflammatory reaction, in a time-dependent manner.

Cited by 39 publications

References 23 publications

Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment

Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment

Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review

Effect on rabbits’ intraocular structure by cross-linked hyaluronic formations as vitreous substitute

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