Comparative Assessment of Tungsten Toxicity in the Absence or Presence of Other Metals

Wasel, Ola; Freeman, Jennifer L.

doi:10.3390/toxics6040066

Cited by 35 publications

(18 citation statements)

References 61 publications

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“…Finding adverse associations for urinary tungsten in the CERAD immediate recall and DSST was unexpected. While tungsten has many uses, it is usually considered to be relatively safe, although it can be detected in soil and potable water [ 61 ]. Rats exposed to sodium tungstate have been reported to show subtle neurobehavioral effects [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Associations between Metal Exposures and Cognitive Function in American Older Adults

Sasaki

Carpenter

2022

IJERPH

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Cognitive function frequently declines with older age, independently of the development of neurodegenerative diseases, and few interventions are known to counter this decline. Exposure to neurotoxic metals may contribute to this decline in cognitive function in older adults. Using the National Health and Nutrition Examination Survey (NHANES) data, the performance of 3042 adults aged 60 years and older on three cognitive tests for immediate, delayed, and working memory were examined in relation to blood concentrations of seven metals and metalloids and urinary concentrations of nineteen metals and metabolites. Using linear regression models, associations between cognitive tests and logarithms of metal exposures were adjusted for age, sex, ethnicity, education level, depression, diabetes, alcohol consumption, and cigarette use. Increased selenium was strongly associated with better performance on all three cognitive tests. Cadmium and lead were negatively associated with performance on all three cognitive tests. Some urinary metabolites of arsenic, urinary lead, cadmium, and tungsten were significantly associated with poor performance on some tests. In older adults, higher selenium levels were strongly associated with better cognitive performance.

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Section: Discussionmentioning

confidence: 99%

Associations between Metal Exposures and Cognitive Function in American Older Adults

Sasaki

Carpenter

2022

IJERPH

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“…However, most of these reports have been on its inhibitive effects on iron, carbon steels, and stainless steels (ferrous metals and alloys) [215,[397][398][399][400][401][402][403][404], with only few reports on tunsgtate inhibition of aluminum corrosion [405][406][407][408]. Though the toxicity of tungsten/tungstate have hitherto been considered to be low [409][410][411][412], recent reports have brought it into scrutiny as an emergent toxicant , and thus the likelihood of tungsten/tungstate use coming under strict regulatory control in the near future is significant.…”

Section: Toxicity Concerns With Respect To Plausible Strategies For Mmentioning

confidence: 99%

The Sealing Step in Aluminum Anodizing: A Focus on Sustainable Strategies for Enhancing Both Energy Efficiency and Corrosion Resistance

2020

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Increasing demands for environmental accountability and energy efficiency in industrial practice necessitates significant modification(s) of existing technologies and development of new ones to meet the stringent sustainability demands of the future. Generally, development of required new technologies and appropriate modifications of existing ones need to be premised on in-depth appreciation of existing technologies, their limitations, and desired ideal products or processes. In the light of these, published literature mostly in the past 30 years on the sealing process; the second highest energy consuming step in aluminum anodization and a step with significant environmental impacts has been critical reviewed in this systematic review. Emphasis have been placed on the need to reduce both the energy input in the anodization process and environmental implications. The implications of the nano-porous structure of the anodic oxide on mass transport and chemical reactivity of relevant species during the sealing process is highlighted with a focus on exploiting these peculiarities, in improving the quality of sealed products. In addition, perspective is provided on plausible approaches and important factors to be considered in developing sealing procedures that can minimize the energy input and environmental impact of the sealing step, and ensure a more sustainable aluminum anodization process/industry.Coatings 2020, 10, 226 2 of 55 sealing methods. Furthermore, the applicability of another hitherto popular sealing process; chromate sealing, is currently limited to essential parts in the aerospace industry due to toxicological, health, and environmental implications traced to Cr(VI) employed in the process [7][8][9][10][11][12][13][14][15][16]. On the other hand, the advantages of another industrially utilized sealing process; the nickel fluoride (cold) sealing process is limited by the toxicity of nickel salts which narrows its range of application, and introduces added costs due to post-sealing wastewater treatments and management [17][18][19][20]. Further efforts at sealing anodized aluminum at temperatures lower than that used in hydrothermal (high temperature) sealing, have led to much variety in the chemical constitution and operating temperatures of sealing baths [21]. On the basis of temperature at which the sealing step is carried out, sealing can be classified into three major categories; high temperature, mid-temperature, and room-temperature or cold sealing. In this work sealing at temperatures from 0 to 40 • C is classified as low temperature sealing, from ≥ 40 • C to 70 • C as intermediate or mid temperature sealing, and sealing at temperatures > 70 • C as high temperature sealing.

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“…Inhibition of these enzymes provides an explanation for the antidiabetic/antiobesity and antihypertensive pharmacological effects of these oxyanions (Fern andez-Mariño et al 2015). Such actions on phosphorylations are also the basis for their toxicological effects observed in pathways leading to gene expression, epigenetic modification, and for posing a carcinogenic potential (Murray et al 2014(Murray et al , 2019Wasel and Freeman 2018).…”

Section: Discussionmentioning

confidence: 99%

Comparative outcomes of exposing human liver and kidney cell lines to tungstate and molybdate

Sachdeva

Maret

2021

Toxicology Mechanisms and Methods

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Tungsten has no known function in humans and is a relatively new contaminant, whereas molybdenum, its congener in the periodic table, is a nutritionally essential element. In addition to early studies on molybdosis in ruminants, their toxic effects in the form of tungstate and molybdate have been addressed primarily in rodents and are predominantly mediated by inducing oxidative stress in various tissues. The purpose of this study was to evaluate the differences between tungstate and molybdate in human liver (HepG2) and kidney (HEK293) cell lines in terms of retention in cells, effect on reactive oxygen species, and activities of xanthine oxidase and phosphatases. The cell lines were exposed to tungstate or molybdate (1 mM to 10 mM) for 24 h, lysed and analyzed for the above biochemical parameters. Despite the chemical similarity of the two anions, cell-specific differential effects were observed. At all concentrations, tungstate was retained more in HEK293 cells while molybdate was retained more in HepG2 cells. HepG2 cells were more sensitive to tungstate than molybdate, showing reduced viability at concentrations as low as 10 mM. Exposure to either anion resulted in the inhibition of protein tyrosine phosphatases at 1 mM and an increased production of reactive oxygen species (ROS) at 100 mM despite their inhibition of the ROS-producing molybdenum enzyme xanthine oxidase. In conclusion, the results indicate that excess of nutritionally essential molybdate or non-essential tungstate causes toxicity by affecting ROS-and phosphorylation-dependent signaling pathways and ensuing gene expression.

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Comparative Assessment of Tungsten Toxicity in the Absence or Presence of Other Metals

Cited by 35 publications

References 61 publications

Associations between Metal Exposures and Cognitive Function in American Older Adults

Associations between Metal Exposures and Cognitive Function in American Older Adults

The Sealing Step in Aluminum Anodizing: A Focus on Sustainable Strategies for Enhancing Both Energy Efficiency and Corrosion Resistance

Comparative outcomes of exposing human liver and kidney cell lines to tungstate and molybdate

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