Comparative bioavailability and pharmacokinetics of sirolimus tablets in healthy Chinese volunteers

Mz, Huang; Chen, JC; Xj, Hu; Liu, Jing; Gl, Wu; Zhou, Huitong; Zhu, Meiping; Lh, Wu; Jz, Shen Tu

doi:10.5414/cp201832

Cited by 4 publications

(2 citation statements)

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“…Blood samples were centrifuged for 10 min at 3000rpm for the extraction of plasma. HPLC technique is used to analyze drug content [26,27]. The obtained data used to determine pharmacokinetic parameters.…”

Section: In-vivopharmacokinetic Studiesmentioning

confidence: 99%

Atenolol And Nifedipine Combination Is Better Than Monotherapy: A New Era In Novel Drug Delivery For Hypertension

Swapna¹,

Maheswaramma²,

Reddy³

2021

JUSST

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Hypertension is considered a major health problems globally affect millions of patient.Various study confirms that single drug treatment usually is not adequate to achieve blood pressure goal in most hypertensive patients.In this regard,consideration is given to combination therapy, which offers the potential advantages towards minimizing hypertension in a rapid manner and produces lower adverse effects.SLTs (Sublingual tablets) provides immediate action to enhanced absorption and bioavailability rate. Sublingual tablets are absorbed within the mucus membrane and directly reach in blood systemic circulation. The objective of this ongoing research focused on theatenolol (ATN)and nifedipine (NIF) combined drug deliveryin emergency condition of hypertension. Direct compression technique is used to formulate SLTsby taking different types and concentrations of superdisintegrantsCroscarmellose sodium (CCS) and Crospovidone (CP). Sublimating agents like camphor (CM) and thymol (TY)) also added for better result. FTIR and DSC analysis confirms the ccompatibility results between drug and superdisintegrants.Formulated tablets are evaluated for different parameters and found satisfactory. Formulation F6 considered as the best formulation. The disintegration shows 13 sec and dissolution profile shows 97.36% drug release at 10 min. Formulation F6 shows better pharmacokinetic activity and antihypertensive activity in compare to pure drug and marketed formulation.A combination of ATN and NIF produces rapid disintegration and dissolution property during an emergency and is a lifesaving approach in hypertension treatment.

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Section: In-vivopharmacokinetic Studiesmentioning

confidence: 99%

Atenolol And Nifedipine Combination Is Better Than Monotherapy: A New Era In Novel Drug Delivery For Hypertension

Swapna¹,

Maheswaramma²,

Reddy³

2021

JUSST

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“…Homogenates were prepared in the saline by using a homogenizer. Drug was extracted from the homogenates and analyzed using HPLC method [29,30].…”

Section: Bio-distribution Studiesmentioning

confidence: 99%

Development and Characterization of Orodispersible Tablets of Propranolol Hydrochloride Using Calcium Cross-Linked Cassia Fistula Gum and Cross Carmellose Sodium

Singh

Sharma²

2020

Int J App Pharm

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Objective: The present investigation was aimed towards developing calcium crosslinked derivative of carboxymethylated cassia fistula gum and crosscarmellose sodium based orodispersible tablets (ODTs) of propranolol hydrochloride for enhancing the bioavailability and efficacy. Methods: Orodispersible tablets (ODTs) of propranolol hydrochloride was formulated using natural (a carboxymethylated derivative of cassia fistula gum) and synthetic polymer (crosscarmellose sodium) by wet and dry granulation, lyophilization and cotton candy methods and then finally compressed by direct compression. The prepared ODTs were evaluated for several parameters such as hardness, friability, in vitro disintegration time, in vitro drug release. In vivo and stability studies were carried out on optimized formulation coding PC1. Results: Drug polymer interaction were judged by FT-IR, DSC and XRD. The optimized formulation coding PC1 prepared by cotton candy process containing 2.5% w/w of crosslinked cassia fistula gum has the least disintegration time (18.9±0.4s), weeting time (12.5±0.8s) and relased the drug of 88.2% within 10 min in contrast to croscarmellose sodium. In vivo absorption studies revealed that same formulation has Cmax (µg/ml) 2.13±0.73, tmax (h) 0.21±0.17 and (µg ml-1 h-1) 14.33±1.59. Conclusion: This research manuscript clearly shows the successful development of the ODTs loaded with an antihypertensive drug, namely propranolol hydrochloride. The formulation developed by cotton candy process utilizing crosslinked cassia fistula gum as a natural superdisintegrant in contrast to other existing techniques can be a best option over synthetic superdisintegrant i.e. crosscarmellose sodium. The prepared ODTs was enhanced the absorption rate by lowering tmax, which inturn enhance the bioavailability and the efficacy of drug.

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L’utilisation de génériques en transplantation : vers des solutions rationnelles et sures !

Rottembourg

Rostoker

2018

La Presse Médicale

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Comparative bioavailability and pharmacokinetics of sirolimus tablets in healthy Chinese volunteers

Abstract: In this single-dose crossover study the test sirolimus tablets met the criteria for bioequivalence in terms of both rate and extent. Each sirolimus formulation was well tolerated during the study.

Cited by 4 publications

References 0 publications

Atenolol And Nifedipine Combination Is Better Than Monotherapy: A New Era In Novel Drug Delivery For Hypertension

Atenolol And Nifedipine Combination Is Better Than Monotherapy: A New Era In Novel Drug Delivery For Hypertension

Development and Characterization of Orodispersible Tablets of Propranolol Hydrochloride Using Calcium Cross-Linked Cassia Fistula Gum and Cross Carmellose Sodium

L’utilisation de génériques en transplantation : vers des solutions rationnelles et sures !

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