Comparative biokinetics of plutonium and americium after inhalation of PuO 2 and mixed oxides (U, Pu)O 2 in rat

Ramounet, S. Matton B.

doi:10.1080/095530000138862

International Journal of Radiation Biology

2000

DOI: 10.1080/095530000138862

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Comparative biokinetics of plutonium and americium after inhalation of PuO 2 and mixed oxides (U, Pu)O 2 in rat

S. Matton B. Ramounet

Abstract: Different transfer rates of Pu and Am from the lung were observed depending on the chemical composition of the oxides and/or the method of their preparation.

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Cited by 18 publications

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“…,Stradling et al (1998), Sato et al (1999,Ramounet et al (2000),ICRP (2002),Stradling et al (2002),Hodgson et al (2003),Ramounet-Le Gall et al (2003),Rateau-Matton et al (2004).…”

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confidence: 99%

Absorption of plutonium compounds in the respiratory tract

Davesne¹,

Paquet²,

Ansoborlo³

et al. 2010

J. Radiol. Prot.

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In order to optimise the monitoring of potentially exposed workers, it is desirable to determine specific values of absorption for the compounds handled. This study derives specific values of absorption rates for different chemical forms of plutonium from in vitro and animal (monkeys, dogs, mice, rats) experiments, and from human contamination cases. Different published experimental data have been reinterpreted here to derive values for the absorption parameters, f(r), s(r) and s(s), used in the human respiratory tract model currently adopted by the International Commission on Radiological Protection (ICRP). The consequences of the use of these values were investigated by calculating related committed effective doses per unit intake. Average and median estimates were calculated for f(r), s(r), and s(s) for each plutonium compound, that can be used as default values for specific chemical forms instead of the current reference types. Nevertheless, it was shown that the use of the current ICRP reference absorption types provides reasonable approximations. Moreover, this work provides estimates of the variability in pulmonary absorption and, therefore, facilitates analyses of the uncertainties associated with assessments, either from bioassay measurements or from prospective calculations, of intake and dose.

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“…,Stradling et al (1998), Sato et al (1999,Ramounet et al (2000),ICRP (2002),Stradling et al (2002),Hodgson et al (2003),Ramounet-Le Gall et al (2003),Rateau-Matton et al (2004).…”

mentioning

confidence: 99%

Absorption of plutonium compounds in the respiratory tract

Davesne¹,

Paquet²,

Ansoborlo³

et al. 2010

J. Radiol. Prot.

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Pulmonary retention of actinides after dissolution of PuO₂aerosols: interest in modelling DTPA decorporation

Sérandour¹,

Fritsch²

2008

Radioprotection

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This study estimates in terms of amount and localisation the pulmonary retention of dissociated Pu/Am in the rat for the first week following an inhalation exposure to industrial PuO 2 aerosols by combining standard biokinetic methods, quantitative analysis of contact autoradiograph obtained from lung section, and treatments by DTPA performed either in vivo or in vitro. The dissociated actinides mainly involved dissolved forms which are homogeneously distributed within lung parenchyma. Most of these chemical forms appears to come from the fraction (f r ) of radioelements which seems to dissolve before particles phagocytosis mainly by alveolar macrophages. Early pulmonary administration of dry diethylenetriaminepentaacetic acid (DTPA) powder (+2 hours) decorporates ~90% of these actinide forms, whereas, a delayed treatment (+1 week) is far less efficient. By contrast, a similar extraction (~90%) of the dissolved actinides from lung sections of rat untreated by the chelating agent is measured after their incubation in a DTPA solution for both 2 hours and 7 days postexposure times. These results can be explained by a gradual internalisation of a fraction of the early dissolved actinides (mainly Am) in alveolar cells, but not preferentially in alveolar macrophages, whereas the remaining fraction of dissolved actinides are transferred to blood. From these observations, a new model is proposed to help for interpretation of human bioassay data obtained after internal contamination and DTPA treatments.

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Survival, lung clearance, dosimetry and gross pathology of rats exposed to either NpO 2 or PuO 2 aerosols

Dudoignon

Guillet

Rateau

et al. 2001

International Journal of Radiation Biology

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Comparative biokinetics of plutonium and americium after inhalation of PuO 2 and mixed oxides (U, Pu)O 2 in rat

Abstract: Different transfer rates of Pu and Am from the lung were observed depending on the chemical composition of the oxides and/or the method of their preparation.

Cited by 18 publications

References 19 publications

Absorption of plutonium compounds in the respiratory tract

Absorption of plutonium compounds in the respiratory tract

Pulmonary retention of actinides after dissolution of PuO₂aerosols: interest in modelling DTPA decorporation

Survival, lung clearance, dosimetry and gross pathology of rats exposed to either NpO 2 or PuO 2 aerosols

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Comparative biokinetics of plutonium and americium after inhalation of PuO 2 and mixed oxides (U, Pu)O 2 in rat

Abstract: Different transfer rates of Pu and Am from the lung were observed depending on the chemical composition of the oxides and/or the method of their preparation.

Cited by 18 publications

References 19 publications

Absorption of plutonium compounds in the respiratory tract

Absorption of plutonium compounds in the respiratory tract

Pulmonary retention of actinides after dissolution of PuO2aerosols: interest in modelling DTPA decorporation

Survival, lung clearance, dosimetry and gross pathology of rats exposed to either NpO 2 or PuO 2 aerosols

Contact Info

Product

Resources

About

Pulmonary retention of actinides after dissolution of PuO₂aerosols: interest in modelling DTPA decorporation