Comparative Characteristics of Clinical Indicators of the Condition of Scar Tissue of the Facial Skin at Different Stages of the Postoperative Period Depending on the Chronotype of the Person

Voloshyna, Liudmyla I; Toropov, O. A.; Boyko, I.V.; Yatsenko, P. I.; Steblovskyi, D.V.; Буханченко, О.П.; Аветіков, Давид Соломонович

doi:10.36740/wlek202206126

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…The compliance of the time of surgical intervention with the circadian rhythm has a positive effect on the processes of reparative regeneration and the background of purulent inflammatory processes [9]. It should also be noted the dependence of markers of lipid peroxidation on the compliance of the time of opening superficial phlegmons of maxillofacial localization with the circadian rhythms of patients, was more clearly observed in both experimental groups [2, [22][23].…”

Section: Discussionmentioning

confidence: 99%

“…The dependence of lipid peroxidation markers on the timing of surgical intervention on the patient's circadian rhythm was established, which is most clearly observed in the 2nd clinical group. Optimal healing of a purulent wound helps to reduce the duration of treatment, accelerate the rehabilitation of patients, and improve the formation of a postoperative scar [1,18,22].…”

Section: Discussionmentioning

confidence: 99%

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Patients' Chronotype Influence in Treatment Efficiency of Placenta Cryerxtract Changes in Maxillofacial Phlegmons

Lokes,

Pérez Sayáns,

Lychman

et al. 2024

Med. and Ecol. probl.

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Among acute odontogenic inflammatory diseases, a significant subset comprises purulent processes in soft tissues, including abscesses and phlegmons. Methods. The study encompassed 90 patients (both male and female) diagnosed with maxillofacial phlegmons, aged between 35 and 60 years. These patients were divided into three clinical groups, each comprising 30 individuals, further categorized into two subgroups based on circadian rhythms. Analyzing the obtained data, it can be asserted that the most significant changes in markers of lipid peroxidation in patients with superficial phlegmons of maxillofacial localization were experienced in both experimental groups when used against the background of treatment according to standard protocols of intravenous injections of the cryopreserved placenta without and in combination with local injection of the cryopreserved placenta as part of "Levomekol" ointment, in contrast to the control group. It was proved that the markers of lipid peroxidation underwent the most significant changes in both clinical groups compared to the control group, but the largest changes were visualized in the second clinical group. On the 5th day of treatment, SOD activity reliably increases by 15.7% in patients with the morning chronotype and 14.9% - with the evening chronotype. A significant decrease in erythrocyte catalase activity by 51.5% was noted in patients with the evening chronotype and 56.1% - with the morning chronotype. In the control group, significant changes were noted only in the late stages of treatment. The dependence of lipid peroxidation markers on the timing of surgical intervention on the patient's circadian rhythm was established, which is most clearly observed in the 2nd clinical group. Optimal healing of a purulent wound helps to reduce the duration of treatment, accelerate the rehabilitation of patients, and improve the formation of a postoperative scar. Conclusion. Thus, aligning the timing of surgical intervention for maxillofacial phlegmons with the patient's circadian rhythm, particularly when combined with intravenous injections and local application of placenta cryoextract alongside standard treatment, contributes to an optimal modulation of lipid peroxidation markers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Patients' Chronotype Influence in Treatment Efficiency of Placenta Cryerxtract Changes in Maxillofacial Phlegmons

Lokes,

Pérez Sayáns,

Lychman

et al. 2024

Med. and Ecol. probl.

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“…При цьому слід мати на увазі, що схеми лікування хворих на ЦД, що традиційно склалися в нашій країні, в останні роки піддаються перегляду з позицій доказової медицини і приводяться у відповідність з міжнародними стандартами. Сучасний підхід до лікування ЦД спрямований не лише на ліквідацію проявів декомпенсації вуглеводного обміну, а й на запобігання розвитку пізніх ускладнень захворювання [4,5,6].…”

Section: методика дослідженняunclassified

“…На наш погляд, важкі наслідки у цих хворих на попередніх етапах лікування були зумовлені взаємозв'язком погано лікованої гнійної інфекції з некомпенсованим ЦД. Це і є основа синдрому «взаємного обтяження», що означає нову форму захворювання зі специфічною несприятливою течією, яка вимагає, на нашу думку, принципово нового підходу до лікування [2,3,4,5,6].…”

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Modern Conception of Treating Purulent Inflammatory Diseases of Face and Neck in Patients With Diabetes Mellitus

Steblovskiy¹

2022

Act. Probl. of the Modern Med.

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The issue of surgical treatment of purulent infection in people suffering from diabetes mellitus is becoming increasingly important that can be explained by a significant growth of diabetes worldwide. The combination of diabetes mellitus and surgical infection forms a closed vicious circle, in which the infection negatively affects metabolic processes, increasing insulin insufficiency and acidosis, while metabolic and microcirculation disorders worsen the course of reparative processes in the lesion. A lack of insulin in patients with diabetes mellitus results in the disorganization of carbohydrate metabolism that is manifested by hyperglycemia, glycosuria, a decrease in the content of glycogen in tissues and, first of all, in the liver. Liver dysfunction, in turn, leads to water-salt and protein metabolisms changes. The impairment of protein metabolism is manifested in a decrease in its synthesis and an increase in its breakdown. As a result, the formation of glucose from amino acids becomes more intensive. The accumulation of ketone bodies and acetone under an almost complete inability to synthesize fats leads to ketoacidosis. The goal of this work is to analyze the treatment outcomes of patients with diabetes mellitus who had various purulent and inflammatory diseases of the maxillofacial area. The treatment of purulent wounds in the patients with diabetes mellitus requires the participation of an endocrinologist to control criteria, which can objectively reflect the course of the wound healing including cytological examination of wound impressions, morphological examination of wound tissues, determination of indicators of tissue homeostasis in the lesion. The use of the methods described above, as well as the scope and direction of therapy in each specific case should be based on the teach approach to this comorbidity. Noteworthy, the course of purulent and inflammatory diseases of the maxillofacial area under diabetes mellitus is peculiar and atypical, often leading to the development of formidable complications and even death. Effective treatment of foci of inflammation under decompensated diabetes is a hard task. Special attention should be paid to the study of the etiopathogenetic mechanisms of the development of purulent-inflammatory diseases of the maxillofacial area in patients with diabetes mellitus and to the development of new treatment algorithms. Close cooperation of maxillofacial surgeons and endocrinologists will help preserve life quality and life expectance of the patients with diabetes mellitus.

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“…Навіть якщо початкове загоєння було незадовільним, зовнішній вигляд рубця можна покращити в післяопераційний період [2,3]. З попередніх досліджень доведено, що на формування післяопераційного рубця впливає також і хронотип людини [4], який відіграє фундаментальну роль у регуляції біологіч-них функцій, температури тіла, гормональну секрецію, споживання їжі, а також когнітивну та фізичну працездатність [5].…”

Section: вступunclassified

The Effect of Placenta Cryoextract on Reparative Processes After Maxillofacial Surgery, Depending on the Patient's Chronotype.

Toropov¹

2022

Act. Probl. of the Modern Med.

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Currently, there is intense interdisciplinary interest and a significant amount of literature on the prevention and treatment of postoperative scars, but international treatment recommendations and regimens have not yet caught up with current knowledge and practice in many medical institutions. The aim of our study was to establish how the biological rhythm can affect the reparative functions of the human body, namely wound healing and scar formation when combining the intraoperative injection of placenta cryoextract and the postoperative electrophoresis on the 90th to 180th day. The research was conducted in the Department of Maxillofacial Surgery on the basis of the Poltava Regional Clinical Hospital. M.V. Sklifosivskyi of the Poltava Regional Council". In total, 40 people took part in the study. On the 90th day of the clinical study, the average score of postoperative scars was as follows: subgroup 1a was 49.3% lower compared to subgroup 2a. A difference of 25.5% could be observed between subgroups 1a and 1b, and 18.5% between subgroups 2a and 2b. From the data of clinical studies, the best results were obtained in subgroup 1a, which indicates the maximum impact of the author's prevention method on the condition of the postoperative scar in patients with a morning chronotype. In this group, a significant decrease in P1, P2, and P7 indicators was established on the 90th day and zero values on the 180th day, respectively; Indicators P3, P4, and P5 recorded the lowest values on the 90th day and a uniform decrease on the 180th and 360th days. Thus, it can be argued that the most optimal results are in patients with the morning type of chronotype, who were injected with placenta cryoextract; the clinical difference was especially noticeable in the earlier period of the postoperative period.

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Comparative Characteristics of Clinical Indicators of the Condition of Scar Tissue of the Facial Skin at Different Stages of the Postoperative Period Depending on the Chronotype of the Person

Cited by 4 publications

References 8 publications

Patients' Chronotype Influence in Treatment Efficiency of Placenta Cryerxtract Changes in Maxillofacial Phlegmons

Patients' Chronotype Influence in Treatment Efficiency of Placenta Cryerxtract Changes in Maxillofacial Phlegmons

Modern Conception of Treating Purulent Inflammatory Diseases of Face and Neck in Patients With Diabetes Mellitus

The Effect of Placenta Cryoextract on Reparative Processes After Maxillofacial Surgery, Depending on the Patient's Chronotype.

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