Comparative characterization of biogenic and chemical synthesized hydroxyapatite biomaterials for potential biomedical application

Mondal, Sudip; Hoang, Giang; Manivasagan, Panchanathan; Moorthy, Madhappan Santha; Kim, Hye Hyun; Phan, Thi Tuong Vy

doi:10.1016/j.matchemphys.2019.02.021

Cited by 71 publications

(26 citation statements)

References 36 publications

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“…There are various natural sources for hydroxyapatite scaffolds which include deproteinized bovine bone, porcine bones, eggshell waste, and woods [ 8 ]. In addition, marine sources offers a wide range of natural sources for extracting hydroxyapatite such as coral, bone fish, fish scales, seashells, nacres, and cuttlefish bones [ 7 , 8 , 9 , 10 , 11 , 12 ]. As the world population increases, the waste from consumption of seafood delicacies also increases.…”

Section: Introductionmentioning

confidence: 99%

“…This type of combination overcomes the weakness of hydroxyapatite, as well as metal scaffolds, by enhancing the mechanical properties and corrosion resistance and, at the same time, promotes bone-bonding ability [ 19 ]. Meanwhile, the sintering process involves formation of a solid mass using heat without melting it to the point of liquefaction [ 10 ]. The sintering process has also been employed to improve the mechanical properties of hydroxyapatite scaffold.…”

Section: Introductionmentioning

confidence: 99%

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Effects of the Sintering Process on Nacre-Derived Hydroxyapatite Scaffolds for Bone Engineering

et al. 2020

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A hydroxyapatite scaffold is a suitable biomaterial for bone tissue engineering due to its chemical component which mimics native bone. Electronic states which present on the surface of hydroxyapatite have the potential to be used to promote the adsorption or transduction of biomolecules such as protein or DNA. This study aimed to compare the morphology and bioactivity of sinter and nonsinter marine-based hydroxyapatite scaffolds. Field emission scanning electron microscopy (FESEM) and micro-computed tomography (microCT) were used to characterize the morphology of both scaffolds. Scaffolds were co-cultured with 5 × 104/cm2 of MC3T3-E1 preosteoblast cells for 7, 14, and 21 days. FESEM was used to observe the cell morphology, and MTT and alkaline phosphatase (ALP) assays were conducted to determine the cell viability and differentiation capacity of cells on both scaffolds. Real-time polymerase chain reaction (rtPCR) was used to identify the expression of osteoblast markers. The sinter scaffold had a porous microstructure with the presence of interconnected pores as compared with the nonsinter scaffold. This sinter scaffold also significantly supported viability and differentiation of the MC3T3-E1 preosteoblast cells (p < 0.05). The marked expression of Col1α1 and osteocalcin (OCN) osteoblast markers were also observed after 14 days of incubation (p < 0.05). The sinter scaffold supported attachment, viability, and differentiation of preosteoblast cells. Hence, sinter hydroxyapatite scaffold from nacreous layer is a promising biomaterial for bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of the Sintering Process on Nacre-Derived Hydroxyapatite Scaffolds for Bone Engineering

et al. 2020

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“…However, in consideration of the high cost associated with chemicals used in the synthetic process, other natural sources were explored for the inexpensive production of HA. Biological sources, such as fish scales, fish bones, bovine bones, egg shells, snail shells, teeth and bones of pig, are among the major sources of natural HA [1,2,25,[53][54][55][56][57][58][59]. Fish scales contain abundant valuable organic and inorganic components, mainly collagen and HA [60].…”

Section: Natural Hydroxyapatitementioning

confidence: 99%

A Brief Review on Biomedical Applications of Hydroxyapatite Use as Fillers in Polymer

Majhooll¹,

Zainol²,

Jaafar³

et al. 2019

JCCE

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Preparation of hydroxyapatite (HA) through natural sources, such as fish scales or synthetic HA produced from the chemical reaction has been widely used as biomedical materials because HA is bioactive, non-toxic and osteoconductive with a crystallographic structure almost similar to that of the bone mineral. In addition, HAwith particle size < 10 microns is classified as common inorganic filler used to improve the mechanical properties and biocompatibility of polymer composites. The purpose of this review is to collect information related to HA, and to provide readers with information about synthesis methods, advantages of hydroxyapatite as biomaterial,biomedical applications of polymer/HA composites.

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“…Excessive colonization of bacteria causing postoperative inflammation has serious consequences for the biocompatibility of calcium phosphate [29]. Several studies have been reported on the antibacterial activity of the biomaterials, including hydroxyapatite against certain types of bacteria, S. pyogenes, S. aureus, S. epidermidis, B. subtilis, K. pneumonia, E. coli, P. mirabilis, P. aeruginosa and B. cereus [23,29,[31][32][33][34][35]. Staphylococcus aureus spherical is one of the most common and most dangerous bacterial species.…”

Section: Introductionmentioning

confidence: 99%

Effect of calcium phosphate synthesis conditions on its physico-chemical properties and evaluation of its antibacterial activity

Guerfi

Chouial

2020

Mater. Res. Express

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The antibacterial activity of non-stoichiometric calcium phosphate particles prepared by precipitation under controlled experimental conditions at pH∼9 and sintered at high temperature was studied against Staphylococcus aureus bacteria. The effects of operating parameters developed according to an experimental design of Plackett-Burman type on the physicochemical characteristics and the capacity to inhibit bacterial growth were identified using a thermal analysis (TGA-DTA-DSC), x-ray Diffraction (XR), Raman Spectroscopy, Scanning Electron Microscope (SEM) and the Kirby Bauer Method. The XRD spectrum shows that the synthetic crystalline nanoparticles powders consist of multiphasic calcium phosphate β-TCP/β-CPP/OCP/HA and that the average particle size is between 56 and 123 nm calculated by the Debay-Shearer equation. The Raman spectrum of sintered powder shows the main absorption bands that are assigned to the asymmetric / symmetric P-O stretching vibrations in PO 4 −3 and the symmetric O-H stretching mode of the hydroxyl group in addition of Ca-PO 4 and Ca-OH modes. The samples were found to possess different morphologies consisting of nano-rods of different lengths, semi / spherical structures and fine granules, in addition to irregular clusters. The antibacterial tests results showed that the high concentration calcium phosphate powder exhibited better antibacterial activity against Staphylococcus aureus bacteria with inhibition zones ranging from 0.2-0.7 cm.

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Comparative characterization of biogenic and chemical synthesized hydroxyapatite biomaterials for potential biomedical application

Cited by 71 publications

References 36 publications

Effects of the Sintering Process on Nacre-Derived Hydroxyapatite Scaffolds for Bone Engineering

Effects of the Sintering Process on Nacre-Derived Hydroxyapatite Scaffolds for Bone Engineering

A Brief Review on Biomedical Applications of Hydroxyapatite Use as Fillers in Polymer

Effect of calcium phosphate synthesis conditions on its physico-chemical properties and evaluation of its antibacterial activity

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