Comparative chemical composition, free radical-scavenging and cytotoxic properties of essential oils of six Stachys species from different regions of the Mediterranean Area

Conforti, Filomena; Menichini, Francesco; Formisano, Carmen; Rigano, Daniela; Senatore, Felice; Arnold, Nelly Apostolides; Piozzi, Franco

doi:10.1016/j.foodchem.2009.03.044

Cited by 99 publications

(50 citation statements)

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“…expectorant, pulmonary emphysema, urogenital diseases, immunostimulant (Ivanova et al 2005); anti-inflammatory, gastroprotective, and cytotoxic (Tadic et al 2012); antioxidant (Koleva et al 2003) leaves, flowers 45 Stachys byzantina C. Koch. antimicrobial, antioxidant, and antifungal (Conforti et al 2009 antibacterial (Nedorostova et al 2011;Joshi 2013) antibacterial, antioxidant, antimalarial, and antiproliferative (Hussain et al 2013);antioxidant and antihypertensive (Mihailovic-Stanojevic et al 2013) leaves 54 Thymus vulgaris L.…”

Section: Medicinal Plants Of the Family Lamiaceaementioning

confidence: 99%

Medicinal plants of the family Lamiaceae as functional foods - a review

Carović‐Stanko¹,

Petek²,

Grdiša³

et al. 2016

Czech J. Food Sci.

180

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Carović-Stanko K., Petek M., Grdiša M., Pintar J., Bedeković D., Herak Ćustić M., Satovic Z. (2016) Historically, species of the family Lamiaceae have enjoyed a rich tradition of use for flavouring, food preservation, and medicinal purposes, due to both their curative and their preventive properties. It is well known that each species has a special, complex mixture of bioactive compounds in which each component contributes to its overall bioactivity. Their value lays in the production of a wide range of secondary metabolites with potent antibacterial, antioxidant, anti-inflammatory, antimicrobial, antiviral, and anticancer activities. This review focuses on the Lamiaceae species and their secondary metabolites encompassing a wide array of beneficial functions and their applicability as sources of functional foods. It could help in addressing specific consumer needs as healthy diet is a part of the lifestyle that maintains or improves overall health.

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Section: Medicinal Plants Of the Family Lamiaceaementioning

confidence: 99%

Medicinal plants of the family Lamiaceae as functional foods - a review

Carović‐Stanko¹,

Petek²,

Grdiša³

et al. 2016

Czech J. Food Sci.

180

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confidence: 74%

“…However, the percentage of these esters decreases from sample MQ1 to sample MQ8, and due to the polarity of eluent, the antioxidant activity decreases. Sample MQ1 was the exception, with a content of FAEs of 58.33%, which is much lower than in the next sample, MQ2, but sample MQ1 showed uniqueness in the content of 2-(1-naphthyl)acetophenone, a member of a class of already known natural antioxidants [11,12]. Total identified 1057 1084 1099 1113 1200 1205 1300 1303 1307 1310 1366 1463 1500 1530 1600 1690 1782 1804 1856 1868 1888 2001 2056 2000 2088 2158 2190 2217 2200 2300 2360 2400 2438 2500 2521 2600 2595 2700 2672 2738 2800 2808 The fact that FAEs found in plant extracts show antioxidant activity is not usual, but literature survey shows that some plant extracts containing a high content of FAMEs could scavenge radicals [13,14].…”

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confidence: 79%

Chemical constituents and antioxidant activity of n-hexane extract of Impatiens bicolor

et al. 2012

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Plants belonging to the genus Impatiens (Balsaminaceae) are rich in organic acids, anthraquinones, and flavonoids [1][2][3]. It is well known that these classes of aromatic compounds possess widespread pharmacological activities. Previous investigations showed that various plant extracts of Impatiens bicolor Royle display antimicrobial and antifungal activity [4,5], as well as acetylcholinesterase inhibition and antioxidant activities [6].Thus, there is a considerable research interest in the assay of composition and/or antioxidant properties of various extracts of I. bicolor. This study presents the very first investigation on the chemical composition of plant extracts of I. bicolor, as well as their antioxidant activities, and it can provide a broad base for the possibility of further detailed pharmacological studies on this species.The sub-extracted samples of the n-hexane fraction of I. bicolor were subjected to detailed GC and GC/MS analysis in order to determine the impact of chemical composition on their antioxidant activity. About 42 compounds were identified in eight samples, representing 56.64-93.85% in total. The percentage compositions of the samples were computed in each case from GC peak areas and are shown in Table 1. In general, all investigated samples can be characterized as mixtures of aliphatic compounds (20.11-93.85%), with oxygenated aliphatic compounds as the most abundant (5.97-89.38%).The fatty acid esters (FAEs) were found to be major components of the investigated subfractions of the n-hexane extract, comprising trans-methyl 13-octadecenoate (2.44-47.29%), methyl heptadecanoate (8.76-18.82%), methyl octadecanoate (4.96-16.49%), methyl docosanoate (3.14-12.64%), methyl tetracosanoate (1.04-11.23%), and methyl eicosanoate (3.83-10.93%). These compounds were mainly found in samples eluted with solvents with relatively low polarity (MQ-1 to MQ-5), while samples eluted with higher polarity (MQ-6 to MQ-8) contained significant amounts of aromatic compounds and shorter-chain oxygenated aliphatic compounds.The antioxidant activity of sub-extracted samples of the n-hexane fraction of I. bicolor were evaluated by DPPH radical-scavenging test. Assessed samples were able to reduce the stable violet DPPH radical to the yellow DPPH-H, reaching 50% of reduction with IC 50 values ranging from 23.22 r 0.75 Pg/mL for sample MQ1 to 59.00 r 2.01 Pg/mL for sample MQ8 (Table 2). Those values are comparable to ascorbic acid (IC 50 = 7.80 r 0.14 Pg/mL), whose antioxidant properties are already known [7,8].Despite the fact that major natural antioxidants belong to the class of phenolic compounds, such as thymol and carvacrol [9, 10], the investigated samples, rich in FAEs, showed radical scavenging activity. The IC 50 values presented in the Table 2 are comparable with the content of FAEs in the investigated sample. However, the percentage of these esters decreases from sample MQ1 to sample MQ8, and due to the polarity of eluent, the antioxidant activity decreases. Sample MQ1 was the exception, with a content o...

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“…The composition of the volatiles is known only for a few species; for example, studies proved that the volatile oil of members of S. lavandulifolia Vahl (sect. Zietenia) consists mainly of monoterpene hydrocarbons, oxygenated monoterpenes, sesquiterpene hydrocarbons, oxygenated sesquiterpenes, diterpenoids and terpene esters [16][17][18][19][20][21][22][23] . The result of new study showed that the essential oil of Stachys mialhesi de Noé has antioxidant, antinociceptive and antiinflammatory effects in laboratory animals.…”

Section: Introductionmentioning

confidence: 99%