Comparative Chemical Studies in Skeletal Muscle Following Neurotomy and Tenotomy

Humoller, Fred L.; Griswold, Barbara; McIntyre, A. R.

doi:10.1152/ajplegacy.1950.161.3.406

Cited by 25 publications

(10 citation statements)

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“…It was demonstrated that the membrane resting potentials of denervated muscle fibres tended to oscillate. The instability of membrane potential, which was not observed in innervated muscle fibres, may indicate metabolic changes in denervated muscles, as evidenced by the studies of Humoller, Griswold & McIntyre (1950) and Humoller, Hatch & McIntyre (1951).…”

Section: Discussionmentioning

confidence: 90%

Some properties of mammalian skeletal muscle fibres with particular reference to fibrillation potentials

Li¹,

Shy²,

Wells³

1957

The Journal of Physiology

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Section: Discussionmentioning

confidence: 90%

Some properties of mammalian skeletal muscle fibres with particular reference to fibrillation potentials

Li¹,

Shy²,

Wells³

1957

The Journal of Physiology

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“…These data suggest that the level of spontaneous fibrillation activity is related to muscle metabolic rate; however, (as has been noted by numerous authors) it is often difficult to determine which changes contribute to development of fibrillation and which are a consequence of it. Indeed, denervated muscle exhibits decreased levels of glycogen 83-85 and changes in activity levels of numerous enzymes (e.g., decreased succinic dehydrogenase 86 and cytochrome oxidase activities 87 with increased hexokinase activity 88 ) and other factors involved in carbohydrate metabolism. 83 , 84 , 86 , 88 In 1950, Humoller and co-workers compared metabolic parameters in denervated and tenotomized muscle and found that glycogen levels dropped in both sets of samples and that in the tenotomized muscles this decline started before the commencement of the fibrillation they detected, suggesting that decreased glycogen levels may contribute to production of the spontaneous activity.…”

Section: Origins and Consequences Of Muscle Fibrillationmentioning

confidence: 99%

History, mechanisms and clinical value of fibrillation analyses in muscle denervation and reinnervation by Single Fiber Electromyography and Dynamic Echomyography

et al. 2014

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This work reviews history, current clinical relevance and future of fibrillation, a functional marker of skeletal muscle denervated fibers. Fibrillations, i.e., spontaneous contraction, in denervated muscle were first described during the nineteenth century. It is known that alterations in membrane potential are responsible for the phenomenon and that they are related to changes in electrophysiological factors, cellular metabolism, cell turnover and gene expression. They are known to inhibit muscle atrophy to some degree and are used to diagnose neural injury and reinnervation that are occurring in patients. Electromyography (EMG) is useful in determining progress, prognosis and efficacy of therapeutic interventions and their eventual change. For patients with peripheral nerve injury, and thus without the option of volitional contractions, electrical muscle stimulation may be helpful in preserving the contractility and extensibility of denervated muscle tissue and in retarding/counteracting muscle atrophy. It is obvious from the paucity of recent literature that research in this area has declined over the years. This is likely a consequence of the decrease in funding available for research and the fact that the fibrillations do not appear to cause serious health issues. Nonetheless, further exploration of them as diagnostic tools in long-term denervation is merited, in particular if Single Fiber EMG (SFEMG) is combined with Dynamic Echomyography (DyEM), an Ultra Sound muscle approach we recently designed and developed to explore denervated and reinnervating muscles.

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“…Intracellular potassium is lost under anaerobic conditions from nerve (Shanes, 1951), from denervated ganglia (Gertner & Reinert, unpublished observations) and from denervated muscle (Humoller, Griswold & McIntyre, 1950a). In denervated muscle there is inhibition of glycogen synthesis and decrease of the resting potential (Ware, Bennett & McIntyre, 1954), reduction of phosphorylation (Varga, Kostya, Szabo, Aszodi & Kesztyiis, 1950) and decrease of ATP and creatine phosphate (Levine, Hechter & Soskin, 1941;Humoller, Griswold & McIntyre, 1950b).…”

Section: Metabolism Of Gangliamentioning

confidence: 99%

On the metabolism of normal and denervated sympathetic ganglion cells

Perry¹,

Reinert²

1955

The Journal of Physiology

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After chronic preganglionic denervation of the superior cervical ganglion of the cat, methonium compounds no longer block but potentiate the effects of injected acetylcholine and, in some 50 % of experiments, themselves cause stimulation of the ganglion cells, as judged by contraction of the nictitating membrane, Furthermore, in normal ganglia, perfused with modified Locke's solution containing a reduced concentration of potassium, the same changes in response to the methonium compounds occur, although even in such conditions these drugs still block preganglionic stimulation (Perry & Reinert, 1954).It was suggested that the methonium compounds could only block transmission when the extracellular potassium ion concentration was normal; and their success in blocking preganglionic stimulation during perfusion with potassium-free Locke's solution was attributed to a local release of potassium from the activated preganglionic nerve endings. That potassium ions appeared to play an important role in these reactions was further indicated by our findings that L-glutamate, which has been shown by and Davies & Krebs (1952) to promote the inwards transfer of potassium ions into many cells against the ionic gradient, when added to the fluid perfusing a denervated ganglion, reversed the effects of denervation (Perry & Reinert, 1954). In this paper we describe further experiments which we have carried out in order to study in more detail the role of potassium ions in these reactions.Krebs and his co-workers found that, of the amino-acids which they studied, only L-glutamate and L-aspartate had a 'potassium carrier-function'. We have, therefore, investigated the action of a number of amino-acids other than L-glutamate, including D-glutamate, L-and D-aspartate, L-and D-alanine, ,B-alanine, L-arginine and L-lysine, in both normal and chronically denervated ganglia.

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Comparative Chemical Studies in Skeletal Muscle Following Neurotomy and Tenotomy

Cited by 25 publications

References 0 publications

Some properties of mammalian skeletal muscle fibres with particular reference to fibrillation potentials

Some properties of mammalian skeletal muscle fibres with particular reference to fibrillation potentials

History, mechanisms and clinical value of fibrillation analyses in muscle denervation and reinnervation by Single Fiber Electromyography and Dynamic Echomyography

On the metabolism of normal and denervated sympathetic ganglion cells

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