“…For clinical trials including only DLSO toenails, mycologic cure rates varied between 74 and 92% for terbinafine, 38,43,54-57 between 61 and 100% for pulse itraconazole, 38,45,54,57-59 69% for continuous itraconazole, 58 between 31 and 67% for fluconazole, 38,40,54,60,61 between 53 and 87% for efinaconazole, 8,35 and between 34 and 70% for ciclopirox. 62,63 One study investigating the efficacy of terbinafine alone or combined with ciclopirox reported significantly different mycologic rates between PSO (1 of 4 = 25%) and DLSO (42 of 54 = 78%) or SO (9 of 10 = 90%). 32 Unfortunately, the authors did not specify the treatment received by the successful cured case of PSO.…”