Comparative clinical evaluation of glycosylated haemoglobin level in healthy and chronic periodontitis patients: A chairside diagnostic method

Srinivasa, T S; Agrawal, Palak; Goyal, Pravesh; Farista, Sana; Sowmya, N K; Deonani, Sushmita

doi:10.4103/0970-9290.172049

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Our results are in concordance with previous studies that reported higher mean HbA1c levels in periodontitis patients than in individuals without periodontitis. [ 24 25 26 27 ] A cutoff value of HbA1c ≥5.7% for prediabetes was used in our study. Interestingly, the mean values for HbA1c fell in the prediabetic range for the severe periodontitis group.…”

Section: Discussionmentioning

confidence: 99%

“…[ 20 21 22 23 ] Few studies have reported higher glycosylated hemoglobin (HbA1c) levels in periodontitis patients than in individuals with healthy periodontium. [ 24 25 26 27 ] Further, studies have also showed an association between severe periodontitis, insulin resistance, and a dysmetabolic state. [ 28 29 30 ] We hypothesized that severe periodontitis patients who were previously undiagnosed for diabetes mellitus had alterations in glycemia when compared to individuals with healthy periodontium.…”

Section: Introductionmentioning

confidence: 99%

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A pilot study on glycemia and insulin resistance in patients with severe periodontitis

George

Narayan

Kurian

et al. 2021

J Indian Soc Periodontol

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Context: The potential impact of severe periodontitis on glycemia in systemically healthy individuals is not clearly established. It was hypothesized that among individuals who were previously undiagnosed for diabetes mellitus, patients with severe periodontitis have impaired glycemia and insulin resistance. Aims: The aim of our study was to assess and compare glycemia in severe periodontitis patients and in individuals with clinically healthy periodontium. Materials and Methods A cross-sectional analytical design was employed. From among individuals who were undiagnosed for diabetes mellitus, 37 patients with severe periodontitis and 37 individuals with healthy periodontium in the age group of 25–55 years were recruited for the study. The fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), and insulin resistance by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) were assessed and compared between the two groups. Results: The mean FBS, HOMA-IR, and HbA1c were significantly higher for patients with severe periodontitis than those individuals with healthy periodontium. After adjustments for age, gender, and body mass index, patients with severe periodontitis had a statistically significant association with impaired glucose metabolism (HbA1c ≥5.7) (adjusted odds ratio [OR] of 9.56; 95% confidence interval [CI]: 1.819–46.08; P < 0.01). Furthermore, patients with severe periodontitis had significantly greater odds to develop impaired fasting glucose (adjusted OR of 7.489, 95% CI: 1.408–39.839; P < 0.01). Conclusions: The mean FBS, HbA1c, and HOMA-IR were significantly higher in severe periodontitis patients than in the control group. A higher proportion of patients presented with prediabetes, incident diabetes, and insulin resistance in the severe periodontitis group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A pilot study on glycemia and insulin resistance in patients with severe periodontitis

George

Narayan

Kurian

et al. 2021

J Indian Soc Periodontol

View full text Add to dashboard Cite

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“… 126 , 127 Given that periodontitis leads to subclinical inflammation, 128 many studies have evaluated the role of periodontitis on glycemic levels, as well as on the incidence of type 2 diabetes and diabetes complications. 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 Periodontitis is associated with hemoglobin A1c progression in individuals with diabetes. 137 Additionally, deeper probing depths are more closely associated with increased hemoglobin A1c levels.…”

Section: Diabetesmentioning

confidence: 99%

“…Chronic subclinical inflammation plays a role in the pathogenesis of type 2 diabetes 126,127 . Given that periodontitis leads to subclinical inflammation, 128 many studies have evaluated the role of periodontitis on glycemic levels, as well as on the incidence of type 2 diabetes and diabetes complications 129‐136 . Periodontitis is associated with hemoglobin A1c progression in individuals with diabetes 137 .…”

Section: Diabetesmentioning

confidence: 99%

Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

Pirih

Monajemzadeh

Singh

et al. 2021

Periodontology 2000

118

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Periodontitis is a "chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by a progressive destruction of the tooth supporting apparatus". 1 Periodontitis affects 42.2% of the US population aged older than 30 years and 59.8% of those aged older than 65 years. 2 According to the World Health Organization, periodontitis is the major cause of tooth loss in adults. 3 Periodontitis pathogenesis is multifactorial with environmental, microbial, and host involvement affecting disease outcomes. Many systemic conditions have been associated with periodontitis, including diabetes mellitus, cardiovascular disease, and metabolic syndrome. [4][5][6][7][8][9][10][11] Metabolic syndrome is a cluster of conditions that occur concomitantly and together they increase the risk of cardiovascular disease and double the risk of type 2 diabetes. [12][13][14][15] Metabolic syndrome affects approximately 34% of the US population 16 and 10% of US adolescents. 17 The prevalence of metabolic syndrome also increases with age and varies with ethnicity and gender. 18 Several definitions of metabolic syndrome exist and differ slightly depending on the issuing agency. The most commonly utilized definition is provided by the National Cholesterol Education Program Adult Treatment Panel III. This definition requires that the individual has at least three of the following risk factors: (a) increased abdominal circumference, (b) low plasma levels of high-density lipoprotein cholesterol, (c) increased values for plasma triglycerides, (d) elevated blood pressure, and (e) elevated glucose levels. 19 Prediabetes is also accepted as part of metabolic syndrome because it is associated with insulin resistance and is highly predictive of new-onset type 2 diabetes. 20The predominant underlying risk factors for metabolic syndrome appear to be abdominal obesity and insulin resistance. Other associated conditions are physical inactivity, aging, and hormonal imbalance. 21 Among the risk factors, visceral adiposity appears to be aThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Screening for dysglycaemia in dental primary care practice settings: systematic review of the evidence

Glurich

Bartkowiak

Berg

et al. 2018

International Dental Journal

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Comparative clinical evaluation of glycosylated haemoglobin level in healthy and chronic periodontitis patients: A chairside diagnostic method

Abstract: Indians are at a high-risk of developing periodontitis and diabetes. These data suggest a possible link between periodontitis and glycemic control in nondiabetic individuals, periodontal disease may be a potential contributor to the development of type 2 diabetes.

Cited by 5 publications

References 11 publications

A pilot study on glycemia and insulin resistance in patients with severe periodontitis

A pilot study on glycemia and insulin resistance in patients with severe periodontitis

Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

Screening for dysglycaemia in dental primary care practice settings: systematic review of the evidence

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