Comparative Colorimetric Sensor Based on Bi-Phase γ-/α-Fe2O3 and γ-/α-Fe2O3/ZnO Nanoparticles for Lactate Detection

Escalona-Villalpando, Ricardo A.; Viveros-Palma, Karen; Espinosa-Lagunes, F.I.; Rodríguez-Morales, José A.; Arriaga, L.G.; Macazo, Florika C.; Ledesma‐García, J.

doi:10.3390/bios12111025

Cited by 3 publications

(3 citation statements)

References 62 publications

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“…Current research continues to explore their use for lactate monitoring in optical biosensors, as evidenced by studies like that by Escalona-Villalpando et al [ 88 ], where Fe 2 O 3 and ZnO nanoparticles were synthesized as peroxidase mimetics for lactate quantification in a colorimetric lactate biosensor. These nanoparticles improved the stability and catalytic activity of LOX enzymes, yielding a more stable signal.…”

Section: Non-invasive Sensors For Lactate Monitoringmentioning

confidence: 99%

Continuous and Non-Invasive Lactate Monitoring Techniques in Critical Care Patients

Lafuente,

González,

Aibar

et al. 2024

Biosensors

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Lactate, once merely regarded as an indicator of tissue hypoxia and muscular fatigue, has now gained prominence as a pivotal biomarker across various medical disciplines. Recent research has unveiled its critical role as a high-value prognostic marker in critical care medicine. The current practice of lactate detection involves periodic blood sampling. This approach is invasive and confined to measurements at six-hour intervals, leading to resource expenditure, time consumption, and patient discomfort. This review addresses non-invasive sensors that enable continuous monitoring of lactate in critical care patients. After the introduction, it discusses the iontophoresis system, followed by a description of the structural materials that are universally employed to create an interface between the integumentary system and the sensor. Subsequently, each method is detailed according to its physical principle, outlining its advantages, limitations, and pertinent aspects. The study concludes with a discussion and conclusions, aiming at the design of an intelligent sensor (Internet of Medical Things or IoMT) to facilitate continuous lactate monitoring and enhance the clinical decision-making support system in critical care medicine.

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Section: Non-invasive Sensors For Lactate Monitoringmentioning

confidence: 99%

Continuous and Non-Invasive Lactate Monitoring Techniques in Critical Care Patients

Lafuente,

González,

Aibar

et al. 2024

Biosensors

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“…For Lact analysis, many optic and electrochemical methods have been proposed [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Most of these methods are nonselective, time-consuming, costly, need pretreatment, and require expensive equipment.…”

Section: Introductionmentioning

confidence: 99%

“…Nanomaterials in the bio-recognition layer of the ABS serve as a matrix for enzyme immobilization and mediate electron transfer from the enzyme to the electrode surface. Nanoparticles (NPs) of metal oxides, metals, semiconductors, and composite NPs or nanohybrids perform various functions in electrochemical conversion circuits; in particular, much attention is paid to their mediator properties [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. To improve electronic exchange between the surface of the working electrode and the enzyme in the planned ABS, a search for optimal nanomediators was performed.…”

Section: Introductionmentioning

confidence: 99%

Flavocytochrome b2-Mediated Electroactive Nanoparticles for Developing Amperometric L-Lactate Biosensors

et al. 2023

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L-Lactate is an indicator of food quality, so its monitoring is essential. Enzymes of L-Lactate metabolism are promising tools for this aim. We describe here some highly sensitive biosensors for L-Lactate determination which were developed using flavocytochrome b2 (Fcb2) as a bio-recognition element, and electroactive nanoparticles (NPs) for enzyme immobilization. The enzyme was isolated from cells of the thermotolerant yeast Ogataea polymorpha. The possibility of direct electron transfer from the reduced form of Fcb2 to graphite electrodes has been confirmed, and the amplification of the electrochemical communication between the immobilized Fcb2 and the electrode surface was demonstrated to be achieved using redox nanomediators, both bound and freely diffusing. The fabricated biosensors exhibited high sensitivity (up to 1436 A·M−1·m−2), fast responses, and low limits of detection. One of the most effective biosensors, which contained co-immobilized Fcb2 and the hexacyanoferrate of gold, having a sensitivity of 253 A·M−1·m−2 without freely diffusing redox mediators, was used for L-Lactate analysis in samples of yogurts. A high correlation was observed between the values of analyte content determined using the biosensor and referenced enzymatic-chemical photometric methods. The developed biosensors based on Fcb2-mediated electroactive nanoparticles can be promising for applications in laboratories of food control.

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Principles and Applications of ZnO Nanomaterials in Optical Biosensors and ZnO Nanomaterial-Enhanced Biodetection

Sytu,

Hahm

2024

Biosensors

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Significant research accomplishments have been made so far for the development and application of ZnO nanomaterials in enhanced optical biodetection. The unparalleled optical properties of ZnO nanomaterials and their reduced dimensionality have been successfully exploited to push the limits of conventional optical biosensors and optical biodetection platforms for a wide range of bioanalytes. ZnO nanomaterial-enabled advancements in optical biosensors have been demonstrated to improve key sensor performance characteristics such as the limit of detection and dynamic range. In addition, all nanomaterial forms of ZnO, ranging from 0-dimensional (0D) and 1D to 2D nanostructures, have been proven to be useful, ensuring their versatile fabrication into functional biosensors. The employment of ZnO as an essential biosensing element has been assessed not only for ensembles but also for individual nanomaterials, which is advantageous for the realization of high miniaturization and minimal invasiveness in biosensors and biodevices. Moreover, the nanomaterials’ incorporations into biosensors have been shown to be useful and functional for a variety of optical detection modes, such as absorption, colorimetry, fluorescence, near-band-edge emission, deep-level emission, chemiluminescence, surface evanescent wave, whispering gallery mode, lossy-mode resonance, surface plasmon resonance, and surface-enhanced Raman scattering. The detection capabilities of these ZnO nanomaterial-based optical biosensors demonstrated so far are highly encouraging and, in some cases, permit quantitative analyses of ultra-trace level bioanalytes that cannot be measured by other means. Hence, steady research endeavors are expected in this burgeoning field, whose scientific and technological impacts will grow immensely in the future. This review provides a timely and much needed review of the research efforts made in the field of ZnO nanomaterial-based optical biosensors in a comprehensive and systematic manner. The topical discussions in this review are organized by the different modes of optical detection listed above and further grouped by the dimensionality of the ZnO nanostructures used in biosensors. Following an overview of a given optical detection mode, the unique properties of ZnO nanomaterials critical to enhanced biodetection are presented in detail. Subsequently, specific biosensing applications of ZnO nanomaterials are discussed for ~40 different bioanalytes, and the important roles that the ZnO nanomaterials play in bioanalyte detection are also identified.

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Comparative Colorimetric Sensor Based on Bi-Phase γ-/α-Fe2O3 and γ-/α-Fe2O3/ZnO Nanoparticles for Lactate Detection

Cited by 3 publications

References 62 publications

Continuous and Non-Invasive Lactate Monitoring Techniques in Critical Care Patients

Continuous and Non-Invasive Lactate Monitoring Techniques in Critical Care Patients

Flavocytochrome b2-Mediated Electroactive Nanoparticles for Developing Amperometric L-Lactate Biosensors

Principles and Applications of ZnO Nanomaterials in Optical Biosensors and ZnO Nanomaterial-Enhanced Biodetection

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