Comparative contamination study with cyclophosphamide, fluorouracil and ifosfamide: standard technique versus a proprietary closed-handling system

Abstract

technique versus a proprietary closed-handling system Comparative contamination study with cyclophosphamide, fluorouracil and ifosfamide: standard Published by: http://www.sagepublications.com can be found at: Journal of Oncology Pharmacy Practice Additional services and information for

Comparison of surface contamination with cyclophosphamide and fluorouracil using a closed-system drug transfer device versus standard preparation techniques

“…This type of background data were not collected in most of the previously published studies. 27,33,34,36 Despite generally low levels of surface contamination in all three pharmacies, levels high enough to warrant corrective action did occur.…”

“…This finding was similar to several other reports of surface contamination with cyclophosphamide. 18,27,35,36 We believe these higher levels to be the result of breaches in technique, though none of the preparers reported problems with manipulation of the CSTD when queried following completion of the CSTD Phase. Surface contamination in this range has been associated with the presence of cyclophosphamide in the urine.…”

“…27,[32][33][34][35] A recently published study did not show reduction in surface contamination; however, problems were noted with the training of participants and methodological changes during the study. 36 Statistical comparisons between the closed-system drug transfer device (CSTD) and standard handling techniques have not been conducted.…”

Microbiological challenge of four protective devices for the reconstitution of cytotoxic agents

“…2003; Poirier et al. 2004; Tans and Willems 2004). However, data are scarce on the microbiological barrier function of this and other systems, i.e.…”

Safe Handling of Antineoplastic Drugs in Oncology Nursing

“…Yapılan çalışmaların sonucunda, antineoplastik ilaçların hazırlanmasında açık ve kapalı sistemlerin olumsuz etkileri açısından kıyaslanması yapılmış ve kapalı sistemle ilaç hazırlamanın çevre ve çalışan sağlığı açısından olumsuz etkileri azalttığına ilişkin kanıtlar bulunmuştur(Connor ve ark., 2002; Wick ve ark. 2003;Spivey and Connor, 2003;Tans and Willems, 2004). Dünya'da ve ülkemizde antineoplastik ilaçların hazırlanması, uygulanması, taşınması ve yönetimi konusunda bir çok standart ve prosedür olmasına karşın istenen düzeyde uygulanmadığı görülmektedir.…”