Comparative dural closure techniques: a safety study in rats

Evaluation of Cyanoacrylate and Fibrin Glue for the Repair of Urethral Incision in Male Goats

“…Marx and Mou (2002) suggested that fibrinolytic activity of urine might be responsible for failure of the fibrin glue tissue adhesives in urinary tract. Further, the tissue holding power of fibrin glue seems t o be lower t h a n t h a t of cyanoacrylate a s the incidence of cerebrospinal fluid leakage was higher following the duramater closure using fibrin glue as compared t o that of cyanoacrylate (Ozisik et al, 2006). All the animals of group IV were sacrificed before the full term; hence retrograde positive contrast urethrography was not performed in these animals.…”

“…Fibrin glue was ~ ~~ *For correspondence: Tel: 0091-581-2302870; e-mail: amarpal8ivri.up.nic.in considered suitable as a n adjuvant t o suturing the skin and bladder (Oosterkinck et al, 1993). However in other studies, it has been used as a sole agent for the repair of ureter in pigs (Mckay et al, 1994) and closure of duramater in rats (Ozisik et al, 2006). Tissue adhesives are easy to apply and their utility has been proved in the repair of different soft tissues in many studies, however, there is paucity of information on the use of cyanoacrylate and fibrin glues for the repair of urethral incision in goats, hence the present study was planned.…”

Effectiveness of a new gelatin sealant system for dural closure

“…Previous experimental studies that have documented the effectiveness of fibrin glue and other tissue adhesives for sealing CSF leakages have been performed on relatively small dural defects. [15][16][17] Fibrin glue is well-known as a material for neurosurgical practice; however, it has some shortcomings, including possible virus transmission, low adhesive strength, troublesome preparation, and high cost. 9 Fluid collection occurred in 26% of patients when fibrin glue was used, and it requires dry surfaces to polymerize, lacks sufficient mechanical strength, and is not easily handled.…”

In situ precise electrospinning of medical glue fibers as nonsuture dural repair with high sealing capability and flexibility

“…However, suture operation, even dural destretching suture, is very difficult to be carried out, when dural defects are friable or located in relatively inaccessible areas. 9 In particular, the prevalence of meningeal tear accompanied with spinal operations urges the discovery of more safe and efficient dural repair techniques.…”