Comparative Effect of Topical Trichloroacetic Acid and Intralesional Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis

Nilforoushzadeh, Mohammad Ali; Jaffary, Fariba; Reiszadeh, M. R.

doi:10.3923/ijp.2006.633.636

Cited by 14 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore the cure rate of topical podophyllin and topical zinc in the present work was higher than topical trichloracitic acid (TCA), which gave (65%) success rate [23], and higher than 5% topical imiquimod plus intralesional meglumine antimony which achieved (40%) cure rate [4]. The above combination beside being expensive they were irritant on application as compared to topical zinc sulphate and topical podophyllin when both were well tolerated and non costly.…”

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Topical Therapy of Acute Cutaneous Leishmaniasis Using Zinc Sulphate Solution 25% versus Podophyllin Solution 25%

Sharquie¹,

Noaimi²,

Sharara³

et al. 2017

JCDSA

View full text Add to dashboard Cite

Background: Zinc sulphate as intralesional and oral therapy was used as a successful therapy in treatment of cutaneous leishmaniasis while 25% topical podophyllin is now commonly used in the treatment of cutaneous leishmaniasis. Objective: To treat acute cutaneous leishmaniasis using topical zinc sulphate solution 25% to be compared with topical podophyllin solution 25%.Patients and Methods: This is a single, blind, interventional, comparative study done in the Department of Dermatology, Baghdad Teaching Hospital, Baghdad, Iraq during the period from January 2015 to June 2015. Forty patients with a total 88 lesions of acute cutaneous leishmaniasis were enrolled in this study; 54 (61.36%) were dry lesions and 34 (38.6%) were ulcerative type. The duration of lesions ranged from 2 -11 (7.7 + 2.483) weeks. The size of the lesions ranged from 0.3 to 8 (2.13 ± 1.53) cm. There were 21 females and 19 males, female to male ratio (1.1:1) and their ages ranged from 1 to 60 (25.92 ± 16.59) years. Diagnosis was confirmed by tissue smear and histopathology. Lesions were divided into two groups with matching types and sizes, and scored according to Sharquie modified Leishmania score to assess the objective response to the topical or systemic therapy and then during follow up responses were graded into mild, moderate, marked response and complete clearance. Group A treated with topical 25% podophyllin solution once weekly for a maximum of 6 weeks, while group B was treated with topical 25% zinc sulphate solution twice daily for 6 weeks. Follow up was every 2 weeks during therapy, and once monthly for 3 months after therapy. Results: A total of 40 patients with clinical diagnosis of acute cutaneous leishmaniasis were included in this study, with a total of 88 lesions. Fifteen (37.50%) patients had Conclusion: Topical zinc sulphate 25% is an effective simple non-invasive non-costly safe topical therapy for cutaneous leishmaniasis and without any contraindications for its use and free of side effects and was as effective as topical podophyllin.

show abstract

Section: Discussionmentioning

confidence: 83%

“…Most recently microwave thermotherapy was used with (85.33%) cure rate [10], topical photodynamic therapy with (93.5%) cure rate [22] and topical podophyllin with (85%) cure rate [16], topical TCA with 65% cure rate [23].…”

Section: Discussionmentioning

confidence: 99%

Topical Therapy of Acute Cutaneous Leishmaniasis Using Zinc Sulphate Solution 25% versus Podophyllin Solution 25%

Sharquie¹,

Noaimi²,

Sharara³

et al. 2017

JCDSA

View full text Add to dashboard Cite

show abstract

“…Nilforoushzadeh and colleagues evaluated intralesional MA and TCA in the treatment of patients with acute CL. 14 They found that after 6 weeks, 68% and 65.7% of patients in the TCA and MA groups, respectively, experienced complete clinical cure. According to this, they concluded that TCA could be as effective as MA in treatment of acute CL.…”

Section: Discussionmentioning

confidence: 97%

“…On the other hand, several physical therapeutic methods are available, including CO 2 laser, cryotherapy, thermotherapy, and trichloroacetic acid (TCA). 9–14…”

mentioning

confidence: 99%

Comparison of Lesion Improvement in Lupoid Leishmaniasis Patients with Two Treatment Approaches

et al. 2015

View full text Add to dashboard Cite

show abstract

“…5 Nilforoushzade et al used TCA along with autologous fibroblast suspension to treat a diabetic foot ulcer 7 and the scar of leshmaniasis. 24 Cho et al reported that a high concentration of TCA (65%-100%) can stimulate dermal fibroblasts and increase the collagen content. 25…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Carbone Dioxide Laser Debridement Along With Low-Level Laser Therapy in Treatment of a Grade 3 Necrotic Burn Ulcer in a Paraplegic Patient (A Case Report)

et al. 2019

View full text Add to dashboard Cite

Introduction: A deep burn ulcer, especially in areas with sensory-motor dysfunction, is hard to cure. Case Report: The patient was a 20-year-old paraplegic girl with a grade 3 necrotic burn ulcer for 3 weeks. We used a fractional Co2 laser along with chemical debridement with trichloroacetic acid (TCA 80%) and low-level laser therapy (LLLT) with a 808 nm infrared laser, 6 J/cm2 for the necrotic area, and a 650 nm red laser, 2 J/cm2 for the open wound area. Complete healing occurred after 25 sessions without surgery. Conclusion: Laser debridement along with LLLT and TCA administration may be useful to treat necrotic ulcers without surgery.

show abstract

Comparative Effect of Topical Trichloroacetic Acid and Intralesional Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis

Cited by 14 publications

References 13 publications

Topical Therapy of Acute Cutaneous Leishmaniasis Using Zinc Sulphate Solution 25% versus Podophyllin Solution 25%

Topical Therapy of Acute Cutaneous Leishmaniasis Using Zinc Sulphate Solution 25% versus Podophyllin Solution 25%

Comparison of Lesion Improvement in Lupoid Leishmaniasis Patients with Two Treatment Approaches

The Efficacy of Carbone Dioxide Laser Debridement Along With Low-Level Laser Therapy in Treatment of a Grade 3 Necrotic Burn Ulcer in a Paraplegic Patient (A Case Report)

Contact Info

Product

Resources

About