Comparative effectiveness clinical trial of magnetic seizure therapy and electroconvulsive therapy in major depressive disorder

Eldeeb, F. A.; Gad, El-Sayed; Kandeel, Ahmed A; Haiba, Amr Adel; Fathy, Sameh M; Peterson, Meghan M; Youssef, Nagy A.

doi:10.12788/acp.0005

Cited by 9 publications

(9 citation statements)

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“…Among the 10 articles finally included, 4 articles are randomized controlled trials (RCT) [ 10 , 13 , 16 , 28 ], 1 article is a controlled crossover experiment [ 29 ], and 5 articles are non-randomized controlled trials [ 12 , 14 , 30 – 32 ]. Due to the particularity of the intervention treatment, it is difficult to achieve a randomized group study.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies used the HAMD scale change score to evaluate the efficacy of treating depression symptoms, and a total of 262 patients were included [ 10 , 12 , 14 , 28 – 32 ]. It should be noted that, as shown in the Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Due to the high heterogeneity, sensitivity analysis by analyzing the influence of single studies showed that the total pooled effect size was greatly affected by the studies of El-Deeb et al [ 32 ]. Excluding this study produced results that the antidepressant effect of the two groups had non-significant, indicated that the MST and the ECT have the same therapeutic effect (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies measured the patients’ reorientation time treated with MST and ECT, and a total of 94 patients were included [ 14 , 29 , 32 ], and all studies showed that the reorientation time was shorter in the MST group. There was high heterogeneity among the studies, and there was still a significant difference in reorientation time between the two groups after one study was excluded from the sensitivity analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Heterogeneity exists in the 10 studies included in this study, which can be explained by several factors. Firstly, the course of treatment varies from 5 to 24 times, and El-Deeb et al study may also result in significant differences [ 32 ]; Secondly, due to the differences caused by different anesthetics, the vast majority used propofol to induce anesthesia, succinylcholine to induce muscle relaxation, and a few used etomidate or atropine to induce anesthesia, resulting in different side effects. White et al’s study may also have great differences [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Comparative efficacy and cognitive function of magnetic seizure therapy vs. electroconvulsive therapy for major depressive disorder: a systematic review and meta-analysis

et al. 2021

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Magnetic seizure therapy (MST) has established efficacy in the treatment of depression and a growing evidence base in the treatment of depression. We conducted the first systematic review and meta-analysis of the efficacy of MST in anti-depressive treatment and its impact on cognitive function (INPLASY registration number: INPLASY202170061). We searched for controlled trials published in English between 1 January 2001 to 31 December 2020 in PubMed, EMBASE, Cochrane Library, Web of Science, and PsycINFO databases. The evaluation process strictly followed the Cochrane bias risk assessment tool into the literature, and Meta-analysis was performed according to the Cochrane System Reviewer’s Manual. Data from a total of 285 patients from 10 studies were retained in the quantitative synthesis. The results showed no significant difference between MST and ECT in the antidepressant effect (SDM −0.13 [−0.78;0.52]). Compared with ECT, MST showed shorter recovery time (MD −5.67 [−9.75; −1.60]) and reorientation time (MD −14.67 [−27.96; −1.41]); and MST showed less cognitive impairment on the immediate recall of words (SDM 0.80 [0.35;1.25]), delayed recall of words (SDM 0.99 [0.01;0.74]), visual-spatial immediate memory (SDM 0.51 [0.20;0.83]), visual-spatial delayed memory (SDM 0.57 [0.11;1.02]), and the verbal fluency (SDM 0.51 [0.20;0.83]). Our evidence-based study is the first meta-analysis on the efficacy of MST in anti-depressive treatment and its effect on cognitive function. It showed that the curative effect of MST in anti-depressive treatment is equivalent to that of ECT. Besides, depressive patients with MST benefit more from cognitive function compared with ECT.

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