Comparative Effects between Bone Marrow and Mesenchymal Stem Cell Transplantation in GDNF Expression and Motor Function Recovery in a Motorneuron Degenerative Mouse Model

Pastor, Diego; Viso-León, Mari Carmen; Jones, Jimmy; Jaramillo-Merchán, Jesús; Toledo‐Aral, Juan José; Moraleda, José Marı́a; Martı́nez, Salvador

doi:10.1007/s12015-011-9295-x

Cited by 48 publications

(41 citation statements)

References 46 publications

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“…1 These MSCs secrete the paracrine factors, vascular endothelial growth factor (VEGF), nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and matrix metalloproteinase-2 (MMP-2), which play an important role in the biological functions of MSCs. [2][3][4][5][6][7] It is important to understand the way in which the synthesis and secretion of these factors are controlled. This will help us better utilize MSCs in clinical situations.…”

Section: Introductionmentioning

confidence: 99%

Hypoxic and ischemic effects on gene and protein expression levels of paracrine factors by human olfactory mucosa mesenchymal-like stem cells

Yuan¹,

Zhuo²,

Su³

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Hypoxic and ischemic effects on gene and protein expression levels of paracrine factors by human olfactory mucosa mesenchymal-like stem cells

Yuan¹,

Zhuo²,

Su³

et al. 2016

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“…Bone marrow cells are responsible for generating blood cells, while mesenchymal stromal cells are responsible for supporting hematopoietic progenitors by regulating the niche microenvironment and by facilitating the maturation of blood cells. Mesenchymal cells can also be extracted from adipose tissue, umbilical cord, skin and placenta [17,18] . Experimental studies have shown that MSCs can survive and migrate to the lesion site, prevent astrogliosis and microglial activation, and delay the loss of motoneurons.…”

Section: Mesenchymal Stem Cells/bone Marrow Stem Cellsmentioning

confidence: 99%

“…Experimental studies have shown that MSCs can survive and migrate to the lesion site, prevent astrogliosis and microglial activation, and delay the loss of motoneurons. A comparative study between BMCs and MSCs showed that BMCs are relatively more effective in motor function recovery and have a higher survival rate [18,19] . In clinical trials with BMCs, authors reported motor and sensory improvement, as well as improvement in patients' quality of life, with some being able to sit again and even get dressed with partial assistance [19][20][21][22][23] .…”

Section: Mesenchymal Stem Cells/bone Marrow Stem Cellsmentioning

confidence: 99%

Adult stem cells in neural repair: Current options, limitations and perspectives

Mariano¹

2015

WJSC

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Stem cells represent a promising step for the future of regenerative medicine. As they are able to differentiate into any cell type, tissue or organ, these cells are great candidates for treatments against the worst diseases that defy doctors and researchers around the world. Stem cells can be divided into three main groups: (1) embryonic stem cells; (2) fetal stem cells; and (3) adult stem cells. In terms of their capacity for proliferation, stem cells are also classified as totipotent, pluripotent or multipotent. Adult stem cells, also known as somatic cells, are found in various regions of the adult organism, such as bone marrow, skin, eyes, viscera and brain. They can differentiate into unipotent cells of the residing tissue, generally for the purpose of repair. These cells represent an excellent choice in regenerative medicine, every patient can be a donor of adult stem cells to provide a more customized and efficient therapy against various diseases, in other words, they allow the opportunity of autologous transplantation. But in order to start clinical trials and achieve great results, we need to understand how these cells interact with the host tissue, how they can manipulate or be manipulated by the microenvironment where they will be transplanted and for how long they can maintain their multipotent state to provide a full regeneration.

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“…Indeed, several studies have shown the efficacy of the BMMC to treat CNS lesions [17][18][19][20] , and clinical studies about the treatment of the SCI with autologous BMMC are in progress 21,22 . There are few comparative studies which suggest that MSCs and BMMCs have very similar potential to promote nervous system rescue and functional recovery 23,24 . An important parameter for the efficiency of a cell therapy is its therapeutic time window after the injury.…”

mentioning

confidence: 99%

“…However, few studies have compared their efficacy into a same experimental design, and they have suggested that these cell types have similar beneficial effects 23,24,27 . Regarding the SCI, Urdzíková et al 23 evaluated the intravenous administration of bone marrow-derived MSC or BMMC a week after lesion in rats and showed that both cell types promoted positive effects on neurological recovery and histopathological process, but the MSC were slightly more effectives.…”

mentioning

confidence: 99%

Comparison among bone marrow mesenchymal stem and mononuclear cells to promote functional recovery after spinal cord injury in rabbits

Fonseca

Scheffer²,

Giraldi-Guimarães³

et al. 2017

Acta Cir. Bras.

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Comparison among bone marrow mesenchymal stem and mononuclear cells to promote functional recovery after spinal cord injury in rabbits 1 Abstract Purpose: To investigate the efficacy of allogeneic mesenchymal stem-cells and autologous mononuclear cells to promote sensorimotor recovery and tissue rescue. Methods: Female rabbits were submitted to the epidural balloon inflation method and the intravenous cells administrations were made after 8 hours or seven days after injury induction. Sensorimotor evaluation of the hindlimbs was performed, and the euthanasia was made thirty days after the treatment. Spinal cords were stained with hematoxylin and eosin. Results: Both therapies given 8 hours after the injury promoted the sensorimotor recovery after a week. Only the group treated after a week with mononuclear cells showed no significant recovery at post-injury day 14. In the days 21 and 28, all treatments promoted significant recovery. Histopathological analysis showed no difference among the experimental groups. Our results showed that both bone marrow-derived cell types promoted significant sensorimotor recovery after injury, and the treatment made at least a week after injury is efficient. Conclusion:The possibilities of therapy with bone marrow-derived cells are large, increasing the therapeutic arsenal for the treatment of spinal cord injury.

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Comparative Effects between Bone Marrow and Mesenchymal Stem Cell Transplantation in GDNF Expression and Motor Function Recovery in a Motorneuron Degenerative Mouse Model

Cited by 48 publications

References 46 publications

Hypoxic and ischemic effects on gene and protein expression levels of paracrine factors by human olfactory mucosa mesenchymal-like stem cells

Hypoxic and ischemic effects on gene and protein expression levels of paracrine factors by human olfactory mucosa mesenchymal-like stem cells

Adult stem cells in neural repair: Current options, limitations and perspectives

Comparison among bone marrow mesenchymal stem and mononuclear cells to promote functional recovery after spinal cord injury in rabbits

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