Comparative Effects of Antidiabetic Drug, Metformin and Deferoxamine, on the Hepatotoxic and Nephrotoxic Side Effects of Streptozotocin-induced Diabetes Mellitus in Rats

Okonkwo, P. O.; Okoye, Z. S. C.

doi:10.9734/bjpr/2014/11812

Cited by 1 publication

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration over streptozotocin [29] causes diabetes by the rapid destroy of pancreatic beta cells, thereby brings about a reduction concerning insulin release and induction of insulin resistance, both of which are associated with type 2 diabetes [30]. In the present study, an increase in blood glucose level among diabetic animals confirms the installation of diabetes mellitus.…”

Section: In Vivo Anti-diabetic Activitysupporting

confidence: 77%

Synthesis, Characterisation, Molecular Docking, Anti-microbial and Anti-diabetic Screening of Substituted 4-indolylphenyl-6-arylpyrimidine-2-imine Derivatives

et al. 2017

View full text Add to dashboard Cite

The purpose of the research is to synthesise a novel series of (E)-2-(4-(1H-indol-3-yl)-6-p-substituted phenylpyrimidin-2-yl)dimethylguanidine derivatives since 3-(1H-indol-3-yl)-1-p-substituted phenylprop-2-en-1-one and evaluate their molecular docking studies, antimicrobial, and anti-diabetic activities. Among all the synthesized compounds (), compound exhibits excellent CDOCKER energy (-11.36 kcal/mol). The entire compounds () confirm very good antimicrobial activity towards the tested microorganisms. In the in vitro anti-diabetic studies, compounds confirm higher alpha-amylase and alpha-glucosidase inhibition activity. In the in vivo anti-diabetic activities, the synthesized compounds (10 mg/kg, p.o.) investigated by the streptozotocin (60 mg/kg, ip) -nicotinamide (120 mg/kg, p.o.) - induced model in adult male albino Wistar rat and these derivatives show considerable fasting blood glucose level when compared to metformin hydrochloride a potent and well-known anti-diabetic drug as a reference.

show abstract

Section: In Vivo Anti-diabetic Activitysupporting

confidence: 77%