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The effect of the antioxidant nutrient selenium, Se, on biologic response to cadmium-induced oxidative cytotoxicity was investigated in rats pretreated with Se prior to exposure to mild doses of Cd. Male wistar strain rats (200-250 g b.wt) were exposed to a single daily oral dose of cadmium (3 mg CdCl 2 /kg) in drinking water for five days following a 15-day oral supplementation with Se (3.0 or 3.5 mg SeO 2 /kg/day) in drinking water at the end of which membrane lipid peroxidation, ascorbic acid and glutathione contents and activities of antioxidant enzymes catalase, superoxide dismutase, and glutathione peroxidase were determined in the red blood cell, liver and kidney samples obtained from treated animals. Cadmium content was determined in liver and kidney samples. Results showed that pre-supplementation with Se effectively countered Cd-induced membrane lipid peroxidation, depletion of non-enzymic antioxidants, ascorbic acid, and glutathione, and induction of antioxidant enzymes catalase, superoxide dismutase, and glutathione peroxidase in the RBC, liver and kidney as well as reduced Cd accumulation in the liver and kidney, all of which effects are consistent with a protective effect of Se against Cd-induced oxidative cytotoxic damage. RBC was the most susceptible to the inhibitory effect of Se pre-supplementation on Cd-induced lipid peroxidation and tissue ascorbic acid and glutathione depletion.

No abstract

Native cereal beer, pito, brewed in Jos metropolis during the 1984 late planting season was screened for zearalenone content. Zearalenone was detected in pito from 28 of the 46 breweries in 13 of the 14 districts sampled, with mean concentration of 81.75 ± 50.16 μg/liter and range 12.50–200.00 μg/liter. Aflatoxin B1 was detected in pooled extracts. There were other chloroform‐soluble isolates but their identities could not be established.

No abstract