Comparative effects of dietary fat and dextrin on mineral oil toxicity in the mouse

The inclusion of 8% mineral oil in a fat-free diet causes severe growth retardation in rats. In the present study, this growth retardation was found to be primarily due to the reduction in nutrient intake, but not to the exacerbation of essential fatty acid deficiency. In addition, the growth retardation caused by mineral oil ingestion was prevented by the concurrent inclusion of 10% water-insoluble dietary fiber [gobo fiber prepared from Arctium lappa L. (gobo in Japanese) or cotton cellulose powder] or 5% fatty acids (C12-C18) as well as glycerol monostearate. The prevention of growth retardation by these substances was due to their ability to inhibit mineral oil absorption from the intestinal lumen.

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Dietary Fiber and Fat-Derivatives Prevent Mineral Oil Toxicity in Rats by the Same Mechanism

Morita

Ebihara

Kiriyama

1993

The Journal of Nutrition

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An Unidentified Factor in Alfalfa Which Counteracts Mineral Oil Toxicity in the Rat and Mouse

Ershoff

Hernandez

1958

The Journal of Nutrition

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Effects of Diet on Fish Oil Toxicity in the Rat

Ershoff

1960

The Journal of Nutrition

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Comparative effects of dietary fat and dextrin on mineral oil toxicity in the mouse

Cited by 3 publications

References 6 publications

Dietary Fiber and Fat-Derivatives Prevent Mineral Oil Toxicity in Rats by the Same Mechanism

Dietary Fiber and Fat-Derivatives Prevent Mineral Oil Toxicity in Rats by the Same Mechanism

An Unidentified Factor in Alfalfa Which Counteracts Mineral Oil Toxicity in the Rat and Mouse

Effects of Diet on Fish Oil Toxicity in the Rat

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