Comparative effects of hawthorn (Crataegus pinnatifida Bunge) pectin and pectin hydrolyzates on the cholesterol homeostasis of hamsters fed high-cholesterol diets

Zhu, Rongshu; Sun, Yandi; Li, Tuoping; Chen, Gang; Peng, Xue; Duan, Wen-Bin; Zheng, Zheng-Zheng; Shi, Shu-Lei; Xu, Jing-Guo; Liu, Yanhua; Jin, Xun

doi:10.1016/j.cbi.2015.06.006

Cited by 49 publications

(27 citation statements)

References 30 publications

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“…In clinical settings, faecal lipid test is used to diagnose lipid malabsorption conditions. Prolonged consumption of high‐cholesterol diet is closely related to the increment of faecal lipid content (Zhu et al ., ). This can be proven by our current findings, whereby the faecal lipid content of the NC rats was significantly lower ( P < 0.05) than the HC and treated rats.…”

Section: Resultsmentioning

confidence: 97%

“…The faecal lipid content was determined using the method of Zhu et al . (). Approximately 0.5 g of faecal powder was mixed with 10 mL chloroform–methanol mixture (2:1, v/v) and agitated with an orbital shaker (Heidolph 1010, Schwabach, Germany) at 150 r.p.m.…”

Section: Methodsmentioning

confidence: 97%

“…The faeces of last 3 days of the experiment were collected and dried in an oven (Binder ED23, Tuttlingen, Germany) at 70°C for 24 h. A mortar and pestle were used to crush the dried faeces into powder. The faecal lipid content was determined using the method of Zhu et al (2015). Approximately 0.5 g of faecal powder was mixed with 10 mL chloroform-methanol mixture (2:1, v/v) and agitated with an orbital shaker (Heidolph 1010, Schwabach, Germany) at 150 r.p.m.…”

Section: Determination Of Faecal Lipid Contentmentioning

confidence: 99%

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Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Tan

Chong

Hamzah

et al. 2018

Int J of Food Sci Tech

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Summary Hypercholesterolaemia is a chronic disease associated with the development of nonalcoholic fatty liver disease and atherosclerosis. This study aimed to investigate the hypocholesterolaemic and hepatoprotective effects of virgin avocado oil (VAO) using diet‐induced hypercholesterolaemia rats. Male Sprague Dawley rats were fed high‐cholesterol diet for 4 weeks to induce hypercholesterolaemia. After confirming the establishment of hypercholesterolaemia model, the VAO (450 and 900 mg kg−1 body weight per day) and simvastatin (10 mg kg−1 body weight per day) were given orally while maintaining the high‐cholesterol diet for another 4 weeks. Changes in anthropometric, lipid profile, liver biomarkers and liver histology were determined. At the end of the experiment, the serum low‐density lipoprotein cholesterol (LDL‐C) and triglyceride (TG) levels were significantly reduced, while the high‐density lipoprotein cholesterol (HDL‐C) level was significantly increased in high‐dose VAO‐ (900 mg kg−1 body weight per day) and simvastatin‐treated rats when compared with their respective baseline values. The liver damage index was also markedly reduced in all treated rats. Current findings demonstrated the potential hypocholesterolaemic and hepatoprotective benefits of VAO in the preclinical study.

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Section: Resultsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 97%

Section: Determination Of Faecal Lipid Contentmentioning

confidence: 99%

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Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Tan

Chong

Hamzah

et al. 2018

Int J of Food Sci Tech

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“…Trichosanthin -anti-tumor [59]; anti-HIV; immunosuppressive [60] -inhibiting cell growth and inducing apoptosis [59] Cell cultures; rodent models Abbreviations: BDNF, brain derived neurophic factor; C/EBP-α, CCAAT enhancer binding protein-α; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; ROS, reactive oxygen species; TGF-β, transforming growth factor-β.…”

Section: Radix Trichosanthismentioning

confidence: 99%

“…It also attenuated mucus secretion and airway inflammation in rats with chronic obstructive pulmonary disease [55]. Crataegus pinnatifida Bunge exerted anti-inflammatory effects [56] and decreased the risks of cardiovascular diseases by lowering blood cholesterol [57][58][59]. Fructus mume exhibited neuroprotective effect through down-regulating inflammation and inhibiting TLR4 and p38 MAPK signaling [60,61].…”

Section: Radix Trichosanthismentioning

confidence: 99%

Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

et al. 2019

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The morbidity of type 2 diabetes mellitus (T2DM) has been increasing rapidly worldwide. Tangminling pill, consisting of ten Chinese herbal medications, is usually prescribed for T2DM in mainland China. Whether treatment with Tangminling can improve clinical outcomes of T2DM patients was still debated. Four studies comparing Tangminling vs. placebo treatment in T2DM patients were included and 767 T2DM patients were enrolled in our analyses. Tangminling treatment exhibited better efficacy than placebo in reducing hemoglobin A1c (HbA1c) (1.11 vs. 0.32%; pooled weighted mean difference [WMD]: 0.80; 95% confidence interval [CI]: 0.65–0.96; P<0.001), fasting plasma glucose (0.82 vs. −0.40 mM; WMD: 1.10; 95% CI: 0.56–1.64; P<0.001), 2-h postprandial glucose (2-hr PG) (2.81 vs. 1.11 mM; WMD: 1.80; 95% CI: 1.72–1.88; P<0.001), homeostatic model assessment-β level (4.28 vs. 0.41; WMD: 0.44; 95% CI: 0.27–0.61; P<0.001), waist circumference (WC) (1.04 vs. 0.36 cm; WMD: 0.78; 95% CI: 0.37–1.19; P<0.001) and body weight index (0.37 vs. 0.11 kg/m2; WMD: 0.30; 95% CI: −0.00 to 0.61; P=0.05). Tangminling pill might reduce glucose level and body weight and improve β-cell function in T2DM patients. Our study highlights the important role of Tangminling pill in the management of T2DM.

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Characterization of hawthorn pectin gained via different ethanol concentrations

Wang

Zhu

Li³

et al. 2023

Food Science & Nutrition

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Pectin is identified as an effective delivery material due to its excellent gel‐forming ability, low immunogenic properties, biocompatibility, and biodegradability. These excellent properties depend on the preparation method of pectin. In the study, four pectin fractions (named: CAHP30, CAHP40, CAHP50, and CAHP60, respectively) were obtained by different ethanol precipitations (30%, 40%, 50%, and 60%). Physicochemical properties, antioxidant activity, and emulsifying ability of HP were investigated and analyzed. Results showed that the surface structure of pectin was changed by ethanol fractional precipitation, and four fractions were low methoxy pectin. They had different monosaccharide compositions, but all rich in GalA. The Mw/Mn of CAHP30, CAHP40, CAHP50, and CAHP60 were 3.29, 2.57, 2.66, and 2.77, respectively. CAHP30 and CAHP60 had excellent emulsifying ability; moreover, CAHP60 was endowed with additional lipid antioxidant capacity and had the best thermal stability. E‐CAHP40 exhibited a property between the entangled network structure. Overall, pectin with specific properties could be obtained by different ethanol concentrations.

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Comparative effects of hawthorn (Crataegus pinnatifida Bunge) pectin and pectin hydrolyzates on the cholesterol homeostasis of hamsters fed high-cholesterol diets

Cited by 49 publications

References 30 publications

Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

Characterization of hawthorn pectin gained via different ethanol concentrations

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