Comparative Effects of Liver and Tumour Ribonucleic Acids on the Normal Liver and the Novikoff Hepatoma Cells of the Rat

DeCarvalho, Sergio; Rand, H. J.

doi:10.1038/189815a0

Cited by 44 publications

(6 citation statements)

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“…Our experiments would thus suggest that some RNA act as inhibitors in certain conditions. This is in keeping with findings of other investigators (15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Transformation of normal lymphocytes may in theory be in fluenced at three points: (1) at the moment of transcription, (2) when the newly-formed RNA transfer from the gene (3) at the moment of translation.…”

Section: Discussionsupporting

confidence: 82%

Delay of Human Lymphocyte ‘Blast’ Transformation by Homologous RNA

et al. 1968

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Section: Discussionsupporting

confidence: 82%

Delay of Human Lymphocyte ‘Blast’ Transformation by Homologous RNA

et al. 1968

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“…A similar result was stated by DeCarvalho et al in the case of Novikoff hepatoma. 6 By treating acute leukemia cells with an RNA isolated from the spleen of calf embryo, some cellular changes, such as increased oxygen uptake, morphological change,8 and formation of tryptophanpyrolases were observed. It was reported further that the cells acquired an ability to produce albumin, tryptophanpyrolase, and glucose-6-phosphatase,~~~~4 when tumor cells were treated with RNA isolated from normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Repression of propagation of ehrlich ascites tumors by means of attenuating tumor cells

Maekawa

Kushibe

1972

Cancer

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RNA obtained from Ehrlich ascites tumor cells, yeast, rice bran, and soy bean, and derivatives of RNA, as well as their complexes formed with some basic polymers, were examined to evaluate the effectiveness in inhibiting tumors. RNA complexes formed with a certain basic polymer were effective to some extent. By means of the pre‐inoculation of tumor cells properly treated with such an RNA complex, the incidence of the tumor was inhibited completely in the challenge inoculation. It could be concluded that the yeast RNA as well as the Ehr. RNA was as effective as the RNA moiety composing the complex.

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“…These included induced protein synthesis in the adult rat (1), embryonic differentiation (2), alterations in production of antibody (3), recovery following lethal irradiation (4), and reversal of neoplastic traits (5,6).…”

Section: Appearance Of Radioactivity In Mouse Cells After Administratmentioning

confidence: 99%

Appearance of Radioactivity in Mouse Cells after Administration of Labeled Macromolecular RNA

Schwarz

Rieke

1962

Science

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Although various induced effects have been reported to follow administration of ribonucleic acid, direct evidence of cellular uptake has been lacking. Radioautographic evidence is presented of incorporation of label from radioactive macromolecular RNA presented to normal and neoplastic mouse cells. Although most of the label appeared in cellular RNA, deoxyribonucleic acid also was occasionally labeled. This suggested that at least partial degradation of the RNA occurred prior to or after incorporation.

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Comparative Effects of Liver and Tumour Ribonucleic Acids on the Normal Liver and the Novikoff Hepatoma Cells of the Rat

Cited by 44 publications

References 1 publication

Delay of Human Lymphocyte ‘Blast’ Transformation by Homologous RNA

Delay of Human Lymphocyte ‘Blast’ Transformation by Homologous RNA

Repression of propagation of ehrlich ascites tumors by means of attenuating tumor cells

Appearance of Radioactivity in Mouse Cells after Administration of Labeled Macromolecular RNA

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