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The proliferating activity of Ehrlich ascites tumor cells decreased with the increase of the concentration of DEPC per 3 x 10 7 cells and disappeared at more than 200 f(g. Sixty per cent of the mice immunized with 200 flg DEPC-treated Ehrlich cells twice survived the challenge inoculation. And employment of Freund's complete adjuvant on the immunization increased the survival ratio up to 90~100%. Respiratory activity, trypan blue stainability and agglutination by concanavalin A were investigated. These results and the electronmicroscopical observation suggest that the specific structure of the cell surface must be maintained in the DEPC-treatment in order to display immunogenicity.

Lysozyme was oxidized with sodium meta-periodate, and the following results were obtained from investigations of the process of oxidation and the changes of lytic activity and absorption spec 1) K.

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