Comparative effects of photobiomodulation therapy at wavelengths of 660 and 808 nm on regeneration of inferior alveolar nerve in rats following crush injury

Diker, Nurettin; Aytac, Duygu; Helvacıoğlu, Fatma; Oğuz, Yener

doi:10.1007/s10103-019-02838-w

Cited by 14 publications

(41 citation statements)

References 35 publications

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“…Among the 13 articles selected [ 34 , 35 , 36 ] ( Supplementary Figure S1 and Table S1 ) using the PRISMA guidelines, none completely comply with the ARRIVE Essential 10, which constitute the recommended guidelines for describing the research context. These studies fail in the accurate inclusion and exclusion criteria.…”

Section: Results Of Articles Screeningmentioning

confidence: 99%

“…These studies fail in the accurate inclusion and exclusion criteria. Additionally, only two works [ 34 , 36 ] described a clear sample size calculation, while in the other articles [ 35 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ], the authors only stated that “efforts were made to minimise the number of animals used and their suffering in accordance with ethical guidelines for investigations of experimental pain in conscious animals”. All of the experimental setups were approved by the relevant Regional Ethics Committee.…”

Section: Results Of Articles Screeningmentioning

confidence: 99%

“…Unfortunately, many articles [ 34 , 35 , 38 , 40 , 42 , 43 , 44 , 45 , 46 ] showed a high risk of bias due to a lack of randomisation and/or blinding of the procedure and were excluded ( Supplementary Tables S1 and S2 ). Therefore, four articles [ 36 , 37 , 39 , 41 ] ( Table 1 ) were selected, and the work of Diker et al [ 36 ] was given a higher score using the ARRIVE guidelines ( Supplementary Table S1 ). The results are summarised in Table 1 and covered more thoroughly in Section 4 .…”

Section: Results Of Articles Screeningmentioning

confidence: 99%

“…Briefly, all of the papers pointed out the efficacy of PBM in treating damage to the trigeminal nerve branches. Diker et al [ 36 ] conducted a histopathological investigation in 36 12-week-old Wistar rats (female), showing that PBM irradiation with 660 nm wavelength light did not reverse the morphological degenerative changes that occurred after IAN injury. Conversely, the 808-nm wavelength light irradiation, illustrated in Figure 2 , reduced the collagen fibre deposition and oedema and preserved the unmyelinated and myelinated nerve structure fibres.…”

Section: Results Of Articles Screeningmentioning

confidence: 99%

“…Regarding nerve regeneration, as suggested by Diker et al [ 36 ], most of the original studies involve animal sciatic nerves, and only a small number investigated the effects of PBM following the injury of the trigeminal nerve branches. Despite not being included in the review process due to nonadherence to many points of the ARRIVE guidelines, nine comparative research articles [ 34 , 35 , 38 , 40 , 42 , 43 , 44 , 45 , 46 ] using a total of 273 rats showed the effects of PBM at different wavelengths and phototherapy parameters on the regeneration of trigeminal nerve branches, neurosensory recovery and pain.…”

Section: Discussionmentioning

confidence: 99%

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Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What’s the Connection? A Review

Ravera

Colombo

Pasquale

et al. 2021

IJMS

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Background: Injury of the trigeminal nerve in oral and maxillofacial surgery can occur. Schwann cell mitochondria are regulators in the development, maintenance and regeneration of peripheral nerve axons. Evidence shows that after the nerve injury, mitochondrial bioenergetic dysfunction occurs and is associated with pain, neuropathy and nerve regeneration deficit. A challenge for research is to individuate new therapies able to normalise mitochondrial and energetic metabolism to aid nerve recovery after damage. Photobiomodulation therapy can be an interesting candidate, because it is a technique involving cell manipulation through the photonic energy of a non-ionising light source (visible and NIR light), which produces a nonthermal therapeutic effect on the stressed tissue. Methods: The review was based on the following questions: (1) Can photo-biomodulation by red and NIR light affect mitochondrial bioenergetics? (2) Can photobiomodulation support damage to the trigeminal nerve branches? (preclinical and clinical studies), and, if yes, (3) What is the best photobiomodulatory therapy for the recovery of the trigeminal nerve branches? The papers were searched using the PubMed, Scopus and Cochrane databases. This review followed the ARRIVE-2.0, PRISMA and Cochrane RoB-2 guidelines. Results and conclusions: The reliability of photobiomodulatory event strongly bases on biological and physical-chemical evidence. Its principal player is the mitochondrion, whether its cytochromes are directly involved as a photoacceptor or indirectly through a vibrational and energetic variation of bound water: water as the photoacceptor. The 808-nm and 100 J/cm2 (0.07 W; 2.5 W/cm2; pulsed 50 Hz; 27 J per point; 80 s) on rats and 800-nm and 0.2 W/cm2 (0.2 W; 12 J/cm2; 12 J per point; 60 s, CW) on humans resulted as trustworthy therapies, which could be supported by extensive studies.

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Section: Results Of Articles Screeningmentioning

confidence: 99%

Section: Results Of Articles Screeningmentioning

confidence: 99%

Section: Results Of Articles Screeningmentioning

confidence: 99%

Section: Results Of Articles Screeningmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What’s the Connection? A Review

Ravera

Colombo

Pasquale

et al. 2021

IJMS

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The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

Alam,

Karami,

Mohammadikhah

et al. 2024

Cell Biochemistry & Function

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The use of photobiomodulation therapy (PBMT) may be used for treating trauma to the maxillofacial region. The effects of PBMT on maxillofacial injuries were discussed in this review article. The electronic databases Pubmed, Scopus, and Web of Science were thoroughly searched. This review included in vitro, in vivo, and clinical studies describing how PBMT can be used in maxillofacial tissue engineering and regenerative medicine. Some studies suggest that PBMT may offer a promising therapy for traumatic maxillofacial injuries because it can stimulate the differentiation and proliferation of various cells, including dental pulp cells and mesenchymal stem cells, enhancing bone regeneration and osseointegration. PBMT reduces pain and swelling after oral surgery and tooth extraction in human and animal models of maxillofacial injuries. Patients with temporomandibular disorders also benefit from PBMT in terms of reduced inflammation and symptoms. PBMT still has some limitations, such as the need for standardizing parameters. PBMT must also be evaluated further in randomized controlled trials in various maxillofacial injuries. As a result, PBMT offers a safe and noninvasive treatment option for patients suffering from traumatic maxillofacial injuries. PBMT still requires further research to establish its efficacy in clinical practice and determine the optimal parameters.

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Dose-dependent effect of the pulsed Nd:YAG laser in the treatment of crushed sciatic nerve in Wister rats: an experimental model

et al. 2020

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Comparative effects of photobiomodulation therapy at wavelengths of 660 and 808 nm on regeneration of inferior alveolar nerve in rats following crush injury

Cited by 14 publications

References 35 publications

Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What’s the Connection? A Review

Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What’s the Connection? A Review

The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

Dose-dependent effect of the pulsed Nd:YAG laser in the treatment of crushed sciatic nerve in Wister rats: an experimental model

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