Comparative efficacy and safety of two 0.025% tretinoin gels: Results from a multicenter, double-blind, parallel study

Luckya, Anne W.; Cullenb, Stanley I.; Jarratt, Michael; Quigley, John W.

doi:10.1016/s0190-9622(98)70141-0

Cited by 47 publications

(22 citation statements)

References 8 publications

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“…Polyolprepolymer-2 helps to retain drug molecules on the skin surface and in the upper layers of the skin [19, 20]. Another new formulation is a microsponge delivery system consisting of macroporous beads of 10–25 µm in diameter which are loaded with an active ingredient.…”

Section: Tretinoinmentioning

confidence: 99%

“…It has been demonstrated that retinoids enhance penetration of its combination partner into the follicular canal. It is furthermore recommended after significant reduction of inflammatory and non-inflammatory lesions to maintain the treatment success with the topical retinoid alone to prevent the new formation of microcomedones [2, 19, 42, 43, 44, 45, 46, 47, 48, 49]. …”

Section: Retinaldehyde and Retinyl-β-glucuronidementioning

confidence: 99%

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Topical Treatment in Acne: Current Status and Future Aspects

Gollnick

Krautheim²

2003

Dermatology

111

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During the last 20 years, the number of topical and systemic drugs for the treatment of acne vulgaris has been enriched. Topical drugs on the one hand have been newly discovered or further developments of already available agents such as in the group of retinoids or galenic formulation have improved efficacy or local tolerance. Topical retinoids are a mainstay in acne treatment since 1962. All-trans retinoic acid was the first and is still in use. Its irritative potential has led to the new galenics, i.e. incorporation in microsponges and in propolyomers, which increased the tolerability significantly. The isomer of tretinoin, isotretinoin, has the same clinical efficacy, but also a lower irritancy. A real breakthrough was adapalene, a retinoid-like agent, with a different retinoid receptor-binding profile, but in addition to the same clinical efficacy on inflammatory and non-inflammatory acne lesions compared to tretinoin, a better tolerability and, therefore, compliance. Unfortunately, over the past years topical retinoids have been less used in inflammatory acne than they should be, taking the the mechanisms of action into account. Topical antimicrobials, in particular topical antibiotics, should be used less often than in the past and only for short periods to avoid the development of resistances. It seems better to combine those agents with topical retinoids, with BPO or with azelaic acid to enhance the efficacy and slow down the development of resistance. BPO is still the gold standard for papular-pustular acne of mild-to-moderate type in concentrations of 2–5%. Azelaic acid is an alternative with efficacy on the comedo and is antibacterial without development of resistances. Finally, the physical removal by electrocautery or CO₂ laser of multiple densely packed closed comedones, macrocomedones and microcysts is necessary to enhance the efficacy of topical comedolytic agents and to speed up the therapeutic results. Photodynamic therapy has not yet been proven efficacious in controlled studies. Blue and red light can probably be used in association with local agents but enhancement of the irritative potential of topical and systemic agents has to be considered.

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Section: Tretinoinmentioning

confidence: 99%

Section: Retinaldehyde and Retinyl-β-glucuronidementioning

confidence: 99%

Topical Treatment in Acne: Current Status and Future Aspects

Gollnick

Krautheim²

2003

Dermatology

111

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“…In this way, it causes significant reduction of noninflammatory and inflammatory acne lesions. Skin irritation, its commonest side-effect, can be diminished with new, liposomal encapsulated tretinoin formulation (gel or cream formulation, which contains polyoprepolymer-2), a large polymer compound that delays absorption of tretinoin in epidermis (11,12). lipase production by Propionibacteria (23).…”

Section: Tretinoinmentioning

confidence: 99%

Treatment of acne vulgaris: a literature review / Lečenje običnih akni (acne vulgaris) – pregled literature

Subotić¹,

Đuran²

2010

Serbian Journal of Dermatology and Venerology

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Acne vulgaris is a common skin disease, which affects individuals of all races and ages. In Caucasians, almost 85% of individuals between 12 and 25 years, as well as 25% of adults, are affected with some forms of acne. The pathophysiology of acne is multifactorial, and thus, the treatment must cover all the possible causes of acne. For this reason, acne therapy is mostly a combination therapy, with the main goal to achieve clinical improvement, without scarring and residuals, as much as possible. The treatment should be planned individually, depending on the clinical appearance, severity and psychological profile of the patient. The treatment usually takes time and requires dedication and patience of both the patient and the physician.

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“…RAL is converted to all-trans-retinoic acid [1,2]. Topical applications of retinoic acid induce irritations of most skins, which often leads to poor compliance [3][4][5]. Topical retinoids have been clinically used for the treatment of comedonal acne for 20 years [5,6], and there is general consensus now for their use in inflammatory acne as well [7].…”

Section: Introductionmentioning

confidence: 99%

“…Another study, against a placebo, yielded a significant decrease in both inflammatory and retentional lesions; tolerance was high [17]. 3 Another study of RAL and glycolic acid, on acne scarring and pigmentation, which includes the Cardiff Acne Disability Index Scale [18], has been presented. 4 This scale is now available in French [18].…”

Section: Introductionmentioning

confidence: 99%

Topical Retinaldehyde with Glycolic Acid: Study of Tolerance and Acceptability in Association with Anti-Acne Treatments in 1,709 Patients

et al. 2005

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Background: Retinaldehyde (RAL), a key metabolite between vitamin A and retinoic acid, acts by modulating differentiation and proliferation of keratinocytes, which is of interest in acne lesions, mainly retentional lesions. Glycolic acid increases the exfoliation of corneocytes explaining its mild activity on retentional lesions. Thus, RAL and glycolic acid combined in the same product (Diacnéal^®) have complementary activities which can be of interest for acne patients. The aim of this study was to evaluate the tolerance of Diacnéal used by 1,709 acne patients in combination with their usual acne products except retinoids. Results: This study demonstrated a very good tolerance of Diacnéal when used with other acne treatments for 90 days. Complaints about side-effects were rare. Moreover, the significant decrease in both inflammatory and retentional lesions between day 0 and day 90 indicates that Diacnéal could amplify the efficiency of other anti-acne products used at the same time by the patients. The subjective evaluation of the preparation’s efficacy by investigators and patients was strongly favourable. Conclusion: These data show that a combination of RAL 0.1% and glycolic acid 6% may be used in association with other topical anti-acne treatments (benzoyl peroxide and topical antibiotics) with an excellent tolerance.

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Comparative efficacy and safety of two 0.025% tretinoin gels: Results from a multicenter, double-blind, parallel study

Cited by 47 publications

References 8 publications

Topical Treatment in Acne: Current Status and Future Aspects

Topical Treatment in Acne: Current Status and Future Aspects

Treatment of acne vulgaris: a literature review / Lečenje običnih akni (acne vulgaris) – pregled literature

Topical Retinaldehyde with Glycolic Acid: Study of Tolerance and Acceptability in Association with Anti-Acne Treatments in 1,709 Patients

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