Topical Retinaldehyde with Glycolic Acid: Study of Tolerance and Acceptability in Association with Anti-Acne Treatments in 1,709 Patients

Dréno, Brigitte; Nocera, Thérèse; Verrière, François; Vienne, M.P.; Segard, Christian P.; Vitse, S; Carré, C

doi:10.1159/000081500

Cited by 16 publications

(13 citation statements)

References 32 publications

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“…Given recent evidence that showed P. acnes‐ induced inflammatory response in patients with acne, which in turn was regulated by vitamin A (retinol is a derivative of vitamin A) and vitamin D, retinoids will continue to be important in acne management . Retinaldehyde, the direct precursor of retinoic acid, has been shown to be efficacious and safe when combined with erythromycin, and it has been shown to be effective and less irritating than other retinoids in a large study of more than 1000 patients …”

Section: Retinol‐based Productsmentioning

confidence: 99%

The role of topical dermocosmetics in acne vulgaris

Araviiskaia

Dréno²

2016

Acad Dermatol Venereol

Self Cite

106

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Acne is a common chronic inflammatory disease and treatment modalities based on acne severity are well established. The role of dermocosmetics in dermatology, and in particular acne, is becoming more important as more research elucidates the mechanisms of action of products in the pathogenesis of acne. Dermocosmetics have the potential to be used as monotherapy or in combination with medical treatment. Therefore, it has become important for dermatologists to understand dermocosmetics to effectively and appropriately advise patients on their use. The objective of this review was to provide new insights into the role of traditional and novel ingredients in dermocosmetics for the treatment of acne, based on the authors' objective assessment of the published literature. The type of products discussed include: those which have a sebostatic effect, such as topical antioxidants and niacinamide; agents targeting abnormal keratinization, such as salicylic acid, lipo-hydroxy acid, alpha-hydroxy acids, retinol-based products and linoleic acid; agents targeting Propionibacterium acnes, such as lauric acid; and anti-inflammatory agents such as nicotinamide, alpha-linolenic acid and zinc salts. Despite the scientific advances in understanding these cosmetic ingredients, there still remains a lack of rigorous controlled studies in this area.

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Section: Retinol‐based Productsmentioning

confidence: 99%

The role of topical dermocosmetics in acne vulgaris

Araviiskaia

Dréno²

2016

Acad Dermatol Venereol

Self Cite

106

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“…have shown the very good tolerance of RAL/GA in a large population of patients ( n = 1709). Even in association with another topical treatment, tolerance was very good; no cutaneous side‐effect was noted, leading to a very high compliance 13 …”

Section: Discussionmentioning

confidence: 99%

Interest of the association retinaldehyde/glycolic acid in adult acne

Dréno

Castell²,

Tsankov

et al. 2009

Journal of the European Academy of Dermatology and Venereology

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“…Its combination with zinc gluconate could be assessed since the latter salt has the capacity to reach the dermis and exert anti-inflammatory and antibacterial effects against Propionibacterium acnes when given by the oral route (53). The implementation of a clinical trial is feasible since the combination of oral zinc and copper gluconate and disulfiram is U.S. Food and Drug Administration approved to treat alcoholism.…”

Section: Discussionmentioning

confidence: 99%

Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in anEx VivoModel System Is Selectively Enhanced by the Addition of Divalent Metal Ions

Peniche

Renslo

Melby

et al. 2015

Antimicrob Agents Chemother

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dCurrent treatments for cutaneous and visceral leishmaniasis are toxic, expensive, difficult to administer, and limited in efficacy and availability. Disulfiram has primarily been used to treat alcoholism. More recently, it has shown some efficacy as therapy against protozoan pathogens and certain cancers, suggesting a wide range of biological activities. We used an ex vivo system to screen several thiuram disulfide compounds for antileishmanial activity. We found five compounds (compound identifier [CID] 7188, 5455, 95876, 12892, and 3117 [disulfiram]) with anti-Leishmania activity at nanomolar concentrations. We further evaluated these compounds with the addition of divalent metal salts based on studies that indicated these salts could potentiate the action of disulfiram. In addition, clinical studies suggested that zinc has some efficacy in treating cutaneous leishmaniasis. Several divalent metal salts were evaluated at 1 M, which is lower than the normal levels of copper and zinc in plasma of healthy individuals. The leishmanicidal activity of disulfiram and CID 7188 were enhanced by several divalent metal salts at 1 M. The in vitro therapeutic index (IVTI) of disulfiram and CID 7188 increased 12-and 2.3-fold, respectively, against L. major when combined with ZnCl 2 . The combination of disulfiram with ZnSO 4 resulted in a 1.8-fold increase in IVTI against L. donovani. This novel combination of thiuram disulfides and divalent metal ions salts could have application as topical and/or oral therapies for treatment of cutaneous and visceral leishmaniasis.T he leishmaniases are vector-borne parasitic diseases with a significant global impact. These diseases occur in more than 88 countries of the world, where approximately 350 million people are at risk. In the Old World, visceral and cutaneous leishmaniasis are caused by the intracellular protozoa Leishmania donovani and Leishmania major, respectively. Visceral leishmaniasis is characterized by impaired parasite-specific cell-mediated immunity and progressive hepatosplenomegaly, anemia, and weight loss and is frequently fatal if left untreated (1). In cutaneous leishmaniasis (CL), the disease severity varies considerably from single self-resolving skin nodules or ulcers to one or more nonhealing lesions, which can be disfiguring (2). The healing response is generally associated with expansion of parasite-specific gamma interferon (IFN-␥)-producing T cells (3).All currently available drug therapies for leishmaniasis have potentially harmful side effects and documented limitations in efficacy. The pentavalent antimony compounds, which are still widely used in many countries, are suboptimal because of the difficulty of administration, well-known host toxicity, and increasing parasite drug resistance. Cure rates have been noted recently to be unacceptably low (4). Other therapies, including amphotericin B desoxycholate and its liposomal formulation, and miltefosine, have been increasingly used in the treatment of visceral or cutaneous leishmaniasis. Their use is al...

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Topical Retinaldehyde with Glycolic Acid: Study of Tolerance and Acceptability in Association with Anti-Acne Treatments in 1,709 Patients

Cited by 16 publications

References 32 publications

The role of topical dermocosmetics in acne vulgaris

The role of topical dermocosmetics in acne vulgaris

Interest of the association retinaldehyde/glycolic acid in adult acne

Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in anEx VivoModel System Is Selectively Enhanced by the Addition of Divalent Metal Ions

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