Comparative efficacy evaluation of catheter intraperitoneal chemotherapy, normothermic and hyperthermic chemoperfusion in a rat model of ascitic ovarian cancer

Abstract

Dioxadet and cisplatin show similar efficacy in the CIPC route. Compared with CIPC IP chemotherapy by chemoperfusions is more effective for both the drugs. Dioxadet in HIPEC showed highest survival benefit whereas largest effect during NIPEC is achieved with cisplatin.

Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy with cisplatin and dioxadet

“…It is demonstrated that holographic analysis of ovarian carcinoma cells taken from rats subjected to chemotherapy can be used for assessment of the treatment efficacy. The conclusions made were shown to be in agreement with recent results on the analysis of these cytostatics efficacy evaluated by experimentally determined survival rates of rats exposed to chemotherapy with these agents [33].…”

“…The conclusions on the cytostatics efficiency made above were compared with the results obtained by the traditional biomedical test. The antitumor efficiency of both cytostatics was previously tested on the same rat model after a single intraperitoneal injection [32,33] and after hyperthermic intraperitoneal chemoperfusion (HIPEC) during surgery [41]. The drug efficiency was evaluated by the increase in median survival of animals.…”

“…The drug efficiency was evaluated by the increase in median survival of animals. The Bayesian statistical analysis of several experiments carried on monitoring of rats lifespan after a single intraperitoneal injection of either CPC or DOD showed that DOD increased median survival by 13 days (85%) while CPC increased that by only 10 days (66%) [33]. Note that surgery + HIPEC caused a different survival pattern: the median survival of rats from the control group which received only surgery was 9 days, while HIPEC provided prolongation up to 25.5 days with CPC and to 49 days with DOD [41].…”

“…Images were recorded by a video system and displayed on a computer screen with NIS-Elements Basic Research (Nikon) software. This methodology has been thoroughly described in our previous report [33].…”

Hyperthermia During Intraperitoneal Chemotherapy With Paclitaxel or Docetaxel for Ovarian Cancer: Is There Any Benefit?

“…These findings may suggest additional toxicity of hyperthermia. In recent studies on rats with intra-abdominal inoculation of ovarian cancer, which were however not subjected to CRS, NIPEC with cisplatin was associated with less morbidity and a small, statistically non-significant, increase of survival when compared with HIPEC with cisplatin (59,60).…”