Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials

Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas

“…Its current therapeutic use is limited to livestock, chiefly as an anticoccidial drug in poultry and to enhance feed efficiency in ruminants. 18,19 Salinomycin induces apoptosis by a caspase-independent mechanism across human cancer cell lines of diverse origin. 20 This study also showed its diminished effects against normal cells, indicating that salinomycin's high in potential for such phenomena is supported by the in vitro data, which shows that surviving Ecad-lo cells after salinomycin treatment retain much less growth potential upon reculture than their cisplatin-treated counterparts.…”

Purification and Molecular Characterization of cGMP-dependent Protein Kinase from Apicomplexan Parasites

“…Stable heterologous expression of the E. tenella PKG cDNA clone with an amino-terminal FLAG-epitope tag ( FLAG EtPKG) has been accomplished in the related Apicomplexan parasite T. gondii. 3,4 Native and recombinant PKG enzyme preparations are indistinguishable in so far as K m for ATP and peptide substrates (summarized in Table II). Inhibition of native and recombinant enzyme activity by Compound 1 is also equivalent.…”

“…The most successful anticoccidials have been the polyether ionophores, a family of compounds that continues to be the industry standard since their introduction nearly 30 years ago (2). Not surprisingly, reports of resistance development due to the extended and constant chemotherapeutic pressure exerted by this class of compounds are not uncommon (3,4). Since that time no novel anticoccidials with efficacy and economic features that approach the ionophore class have been introduced into the poultry industry.…”

Salinomycin in cancer: A new mission for an old agent

“…Therefore, salinomycin has been used for more than 30 years as an effective anticoccidial drug in poultry (8) and is also fed to ruminants and pigs to improve nutrient absorption and feed efficiency (9)(10)(11).…”